Funeral music

Digitoitu 16. 10. 2008.

Sinfonisia muunnelmia

Soitinnus: orkesteri.

Entre Catalunya i Polònia: Witold Gombrowicz i Gabriel Ferrater: correspondència inèdita (1965-1967)

En el present treball, he intentat respondre la pregunta sobre per què Gabriel Ferrater es va interessar tant per l’obra de Witold Gombrowicz. Segurament, havia conegut la seva literatura en una traducció francesa i més possible encara alemanya, ja que el traductor va estar treballant a Hamburg per l’editorial Rowohlt Verlag com a lector. Devia assabentar-se de l’èxit de les obres de Gombrowicz a França i Alemanya i potser va decidir que era l’hora d’introduir-lo al mercat espanyol. Com comenta Janet Rodney, en el correu electrònic adjunt als apèndixs del treball, potser Ferrater veia algunes semblances entre ell mateix i Gombrowicz. Tots dos tenien problemes per publicar la seva obra sencera als seus països d’origen i, tot i que Gombrowicz ja feia molt de temps que no vivia a Polònia, sempre havia conservat el desig de poder ser publicat, sense censura, al seu país natal. Potser també tots dos escriptors compartien el sentiment d’inferioritat de les seves cultures respecte les de l’Europa Occidental. Tots dos intentaven mostrar en la seva obra literària l’existència d’una realitat potser oculta però tan legítima com les altres, com la “realitat oficial” en la que havien de viure

Aspects de l'identité narrative chez Witold Gombrowicz et Virginia Woolf

À la lumière de la théorie de l’identité narrative élaborée par Paul Ricœur, ce mémoire évoque la configuration identitaire des personnages dans les œuvres Cosmos et Les envoûtés de W. Gombrowicz, ainsi que To the Lighthouse et The Waves de V. Woolf. D’une part, nous analyserons l’obsession d’une mise en série aliénante dans le cas de Witold (Cosmos), suivi par un cas de dédoublement et de perte dans l’Autre chez Walczak (Les envoûtés). D’autre part, nous évoquerons le rapport à la famille (James Ramsay) en plus de l’inscription et de l’ancrage par le biais d’éléments prépondérants (The Waves). Il en résulte chez ces personnages, la conception d’une identité par l’entremise d’histoires et d’événements qui la façonnent en un parcours narratif singulier.

El diálogo que no llegó a ser. El debate entre Emile Cioran y Witold Gombrowicz sobre los escritores exiliados

El artículo analiza las respuestas que el escritor polaco Witold Gombrowicz (que se exilió de Polonia en Argentina a entre 1939 y 1963), dio al filósofo rumano Emile Cioran, quien en 1953 publicó "Ventajas y desventajas del exilio", un provocativo ensayo en el cual habla acerca de los escritores en el exilio. El texto motivó un interesante debate por parte del polaco, que aunque no llegó a prosperar, es muy simbólico de la situación de la época

El diálogo que no llegó a ser. El debate entre Emile Cioran y Witold Gombrowicz sobre los escritores exiliados

El artículo analiza las respuestas que el escritor polaco Witold Gombrowicz (que se exilió de Polonia en Argentina a entre 1939 y 1963), dio al filósofo rumano Emile Cioran, quien en 1953 publicó "Ventajas y desventajas del exilio", un provocativo ensayo en el cual habla acerca de los escritores en el exilio. El texto motivó un interesante debate por parte del polaco, que aunque no llegó a prosperar, es muy simbólico de la situación de la época

El diálogo que no llegó a ser. El debate entre Emile Cioran y Witold Gombrowicz sobre los escritores exiliados

El artículo analiza las respuestas que el escritor polaco Witold Gombrowicz (que se exilió de Polonia en Argentina a entre 1939 y 1963), dio al filósofo rumano Emile Cioran, quien en 1953 publicó "Ventajas y desventajas del exilio", un provocativo ensayo en el cual habla acerca de los escritores en el exilio. El texto motivó un interesante debate por parte del polaco, que aunque no llegó a prosperar, es muy simbólico de la situación de la época

The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA.CER) trial: study design and rationale

Background The protease-activated receptor 1 (PAR-1), the main platelet receptor for thrombin, represents a novel target for treatment of arterial thrombosis, and SCH 530348 is an orally active, selective, competitive PAR-1 antagonist. We designed TRA.CER to evaluate the efficacy and safety of SCH 530348 compared with placebo in addition to standard of care in patients with non-ST-segment elevation (NSTE) acute coronary syndromes (ACS) and high-risk features. Trial design TRA.CER is a prospective, randomized, double-blind, multicenter, phase III trial with an original estimated sample size of 10,000 subjects. Our primary objective is to demonstrate that SCH 530348 in addition to standard of care will reduce the incidence of the composite of cardiovascular death, myocardial infarction (MI), stroke, recurrent ischemia with rehospitalization, and urgent coronary revascularization compared with standard of care alone. Our key secondary objective is to determine whether SCH 530348 will reduce the composite of cardiovascular death, MI, or stroke compared with standard of care alone. Secondary objectives related to safety are the composite of moderate and severe GUSTO bleeding and clinically significant TIMI bleeding. The trial will continue until a predetermined minimum number of centrally adjudicated primary and key secondary end point events have occurred and all subjects have participated in the study for at least I year. The TRA.CER trial is part of the large phase III SCH 530348 development program that includes a concomitant evaluation in secondary prevention. Conclusion TRA.CER will define efficacy and safety of the novel platelet PAR-1 inhibitor SCH 530348 in the treatment of high-risk patients with NSTE ACS in the setting of current treatment strategies. (Am Heart J 2009; 158:327-34.)

Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine

The persistent nature of addiction has been associated with activity-induced plasticity of neurons within the striatum and nucleus accumbens (NAc). To identify the molecular processes leading to these adaptations, we performed Cre/loxP-mediated genetic ablations of two key regulators of gene expression in response to activity, the Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) and its postulated main target, the cAMP-responsive element binding protein (CREB). We found that acute cocaine-induced gene expression in the striatum was largely unaffected by the loss of CaMKIV. On the behavioral level, mice lacking CaMKIV in dopaminoceptive neurons displayed increased sensitivity to cocaine as evidenced by augmented expression of locomotor sensitization and enhanced conditioned place preference and reinstatement after extinction. However, the loss of CREB in the forebrain had no effect on either of these behaviors, even though it robustly blunted acute cocaine-induced transcription. To test the relevance of these observations for addiction in humans, we performed an association study of CAMK4 and CREB promoter polymorphisms with cocaine addiction in a large sample of addicts. We found that a single nucleotide polymorphism in the CAMK4 promoter was significantly associated with cocaine addiction, whereas variations in the CREB promoter regions did not correlate with drug abuse. These findings reveal a critical role for CaMKIV in the development and persistence of cocaine-induced behaviors, through mechanisms dissociated from acute effects on gene expression and CREB-dependent transcription.

Molecular dynamics computer simulation of scratch resistance testing of polymers: visualization

Experimental scratch resistance testing provides two numbers: the penetration depth Rp and the healing depth Rh. In molecular dynamics computer simulations, we create a material consisting of N statistical chain segments by polymerization; a reinforcing phase can be included. Then we simulate the movement of an indenter and response of the segments during X time steps. Each segment at each time step has three Cartesian coordinates of position and three of momentum. We describe methods of visualization of results based on a record of 6NX coordinates. We obtain a continuous dependence on time t of positions of each of the segments on the path of the indenter. Scratch resistance at a given location can be connected to spatial structures of individual polymeric chains.

Polymer indentation with mesoscopic molecular dynamics

Indentation tests are used to determine the hardness of a material, e.g., Rockwell, Vickers, or Knoop. The indentation process is empirically observed in the laboratory during these tests; the mechanics of indentation is insufficiently understood. We have performed first molecular dynamics computer simulations of indentation resistance of polymers with a chain structure similar to that of high density polyethylene (HDPE). A coarse grain model of HDPE is used to simulate how the interconnected segments respond to an external force imposed by an indenter. Results include the time-dependent measurement of penetration depth, recovery depth, and recovery percentage, with respect to indenter force, indenter size, and indentation time parameters. The simulations provide results that are inaccessible experimentally, including continuous evolution of the pertinent tribological parameters during the entire indentation process.