610 resultados para Lexington, Kentucky.


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National Highway Traffic Safety Administration, Washington, D.C.

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Mode of access: Internet.

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Includes bibliographical references.

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Black and white, 19 cm x 29 cm photograph of Julia C. Woodruff, Thomas Adam Woodruff, Hamilton Killaly Woodruff, Margaret Julia Woodruff, Uncle Henry Woodruff and Aunt Emma Woodruff along with Mary (“a home girl”) and Spot the dog. The photo was taken at Woodbourne in St. David’s. The photograph was taken by Will Boomer of Lexington Kentucky.

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BACKGROUND: Meningomyelocele (MM) is a common human birth defect. MM is a disorder of neural development caused by contributions from genes and environmental factors that result in the NTD and lead to a spectrum of physical and neurocognitive phenotypes. METHODS: A multidisciplinary approach has been taken to develop a comprehensive understanding of MM through collaborative efforts from investigators specializing in genetics, development, brain imaging, and neurocognitive outcome. Patients have been recruited from five different sites: Houston and the Texas-Mexico border area; Toronto, Canada; Los Angeles, California; and Lexington, Kentucky. Genetic risk factors for MM have been assessed by genotyping and association testing using the transmission disequilibrium test. RESULTS: A total of 509 affected child/parent trios and 309 affected child/parent duos have been enrolled to date for genetic association studies. Subsets of the patients have also been enrolled for studies assessing development, brain imaging, and neurocognitive outcomes. The study recruited two major ethnic groups, with 45.9% Hispanics of Mexican descent and 36.2% North American Caucasians of European descent. The remaining patients are African-American, South and Central American, Native American, and Asian. Studies of this group of patients have already discovered distinct corpus callosum morphology and neurocognitive deficits that associate with MM. We have identified maternal MTHFR 667T allele as a risk factor for MM. In addition, we also found that several genes for glucose transport and metabolism are potential risk factors for MM. CONCLUSIONS: The enrolled patient population provides a valuable resource for elucidating the disease characteristics and mechanisms for MM development.

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National Highway Traffic Safety Administration, Washington, D.C.

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This conference was called by the Kentucky Council of defense to consider various matters arising out of the war and Kentucky's relation to them. cf. p. [5].