Lenox, Massachusetts, 1854 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Map of the town of Lenox : Berkshire Co. Massachusetts, surveyed and drawn by E.M. Woodford ; E. Herrlein's lith. It was published by Richard Clark in 1854. Scale [ca. 1:20,000]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads and stations, drainage, public buildings, schools, churches, cemeteries, industry locations (e.g. mills, factories, mines, etc.), private buildings with names of property owners, town district boundaries, and more. Relief shown by hachures. Includes also illustrations and insets: [Cemetery & surrounding residencies] -- Lenox Furnace.This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

A sermon,delivered at Lenox, Mass.,Feb. 20th,1806; being the day of the execution of Ephraim Wheeler,pursuant to his sentence,for a rape committed on his daughter, Betsy Wheeler.

Mode of access: Internet.

The boy scout of Lenox; or, The hike over Big Bear mountain,

Mode of access: Internet.

Contributions to a catalog of the Lenox library

Mode of access: Internet.

Risk Factors for Visual Field Progression in Treated Glaucoma

Objective: To determine intraocular pressure (IOP)-dependent and IOP-independent variables associated with visual field (VF) progression in treated glaucoma. Design: Retrospective cohort of the Glaucoma Progression Study. Methods: Consecutive, treated glaucoma patients with repeatable VF loss who had 8 or more VF examinations of either eye, using the Swedish Interactive Threshold Algorithm (24-2 SITA-Standard, Humphrey Field Analyzer II; Carl Zeiss Meditec, Inc, Dublin, California), during the period between January 1999 and September 2009 were included. Visual field progression was evaluated using automated pointwise linear regression. Evaluated data included age, sex, race, central corneal thickness, baseline VF mean deviation, mean follow-up IOP, peak IOP, IOP fluctuation, a detected disc hemorrhage, and presence of beta-zone parapapillary atrophy. Results: We selected 587 eyes of 587 patients (mean [SD] age, 64.9 [13.0] years). The mean (SD) number of VFs was 11.1 (3.0), spanning a mean (SD) of 6.4 (1.7) years. In the univariable model, older age (odds ratio [OR], 1.19 per decade; P = .01), baseline diagnosis of exfoliation syndrome (OR, 1.79; P = .01), decreased central corneal thickness (OR, 1.38 per 40 mu m thinner; P < .01), a detected disc hemorrhage (OR, 2.31; P < .01), presence of beta-zone parapapillary atrophy (OR, 2.17; P < .01), and all IOP parameters (mean follow-up, peak, and fluctuation; P < .01) were associated with increased risk of VF progression. In the multivariable model, peak IOP (OR, 1.13; P < .01), thinner central corneal thickness (OR, 1.45 per 40 mu m thinner; P < .01), a detected disc hemorrhage (OR, 2.59; P < .01), and presence of beta-zone parapapillary atrophy (OR, 2.38; P < .01) were associated with VF progression. Conclusions: IOP-dependent and IOP-independent risk factors affect disease progression in treated glaucoma. Peak IOP is a better predictor of progression than is IOP mean or fluctuation.

Three essays in control, entrepreneurship and innovation

One of the key emphases of these three essays is to provide practical managerial insight. However, good practical insight, can only be created by grounding it firmly on theoretical and empirical research. Practical experience-based understanding without theoretical grounding remains tacit and cannot be easily disseminated. Theoretical understanding without links to real life remains sterile. My studies aim to increase the understanding of how radical innovation could be generated at large established firms and how it can have an impact on business performance as most businesses pursue innovation with one prime objective: value creation. My studies focus on large established firms with sales revenue exceeding USD $ 1 billion. Usually large established firms cannot rely on informal ways of management, as these firms tend to be multinational businesses operating with subsidiaries, offices, or production facilities in more than one country. I. Internal and External Determinants of Corporate Venture Capital Investment The goal of this chapter is to focus on CVC as one of the mechanisms available for established firms to source new ideas that can be exploited. We explore the internal and external determinants under which established firms engage in CVC to source new knowledge through investment in startups. We attempt to make scholars and managers aware of the forces that influence CVC activity by providing findings and insights to facilitate the strategic management of CVC. There are research opportunities to further understand the CVC phenomenon. Why do companies engage in CVC? What motivates them to continue "playing the game" and keep their active CVC investment status. The study examines CVC investment activity, and the importance of understanding the influential factors that make a firm decide to engage in CVC. The main question is: How do established firms' CVC programs adapt to changing internal conditions and external environments. Adaptation typically involves learning from exploratory endeavors, which enable companies to transform the ways they compete (Guth & Ginsberg, 1990). Our study extends the current stream of research on CVC. It aims to contribute to the literature by providing an extensive comparison of internal and external determinants leading to CVC investment activity. To our knowledge, this is the first study to examine the influence of internal and external determinants on CVC activity throughout specific expansion and contraction periods determined by structural breaks occurring between 1985 to 2008. Our econometric analysis indicates a strong and significant positive association between CVC activity and R&D, cash flow availability and environmental financial market conditions, as well as a significant negative association between sales growth and the decision to engage into CVC. The analysis of this study reveals that CVC investment is highly volatile, as demonstrated by dramatic fluctuations in CVC investment activity over the past decades. When analyzing the overall cyclical CVC period from 1985 to 2008 the results of our study suggest that CVC activity has a pattern influenced by financial factors such as the level of R&D, free cash flow, lack of sales growth, and external conditions of the economy, with the NASDAQ price index as the most significant variable influencing CVC during this period. II. Contribution of CVC and its Interaction with R&D to Value Creation The second essay takes into account the demands of corporate executives and shareholders regarding business performance and value creation justifications for investments in innovation. Billions of dollars are invested in CVC and R&D. However there is little evidence that CVC and its interaction with R&D create value. Firms operating in dynamic business sectors seek to innovate to create the value demanded by changing market conditions, consumer preferences, and competitive offerings. Consequently, firms operating in such business sectors put a premium on finding new, sustainable and competitive value propositions. CVC and R&D can help them in this challenge. Dushnitsky and Lenox (2006) presented evidence that CVC investment is associated with value creation. However, studies have shown that the most innovative firms do not necessarily benefit from innovation. For instance Oyon (2007) indicated that between 1995 and 2005 the most innovative automotive companies did not obtain adequate rewards for shareholders. The interaction between CVC and R&D has generated much debate in the CVC literature. Some researchers see them as substitutes suggesting that firms have to choose between CVC and R&D (Hellmann, 2002), while others expect them to be complementary (Chesbrough & Tucci, 2004). This study explores the interaction that CVC and R&D have on value creation. This essay examines the impact of CVC and R&D on value creation over sixteen years across six business sectors and different geographical regions. Our findings suggest that the effect of CVC and its interaction with R&D on value creation is positive and significant. In dynamic business sectors technologies rapidly relinquish obsolete, consequently firms operating in such business sectors need to continuously develop new sources of value creation (Eisenhardt & Martin, 2000; Qualls, Olshavsky, & Michaels, 1981). We conclude that in order to impact value creation, firms operating in business sectors such as Engineering & Business Services, and Information Communication & Technology ought to consider CVC as a vital element of their innovation strategy. Moreover, regarding the CVC and R&D interaction effect, our findings suggest that R&D and CVC are complementary to value creation hence firms in certain business sectors can be better off supporting both R&D and CVC simultaneously to increase the probability of generating value creation. III. MCS and Organizational Structures for Radical Innovation Incremental innovation is necessary for continuous improvement but it does not provide a sustainable permanent source of competitiveness (Cooper, 2003). On the other hand, radical innovation pursuing new technologies and new market frontiers can generate new platforms for growth providing firms with competitive advantages and high economic margin rents (Duchesneau et al., 1979; Markides & Geroski, 2005; O'Connor & DeMartino, 2006; Utterback, 1994). Interestingly, not all companies distinguish between incremental and radical innovation, and more importantly firms that manage innovation through a one-sizefits- all process can almost guarantee a sub-optimization of certain systems and resources (Davila et al., 2006). Moreover, we conducted research on the utilization of MCS along with radical innovation and flexible organizational structures as these have been associated with firm growth (Cooper, 2003; Davila & Foster, 2005, 2007; Markides & Geroski, 2005; O'Connor & DeMartino, 2006). Davila et al. (2009) identified research opportunities for innovation management and provided a list of pending issues: How do companies manage the process of radical and incremental innovation? What are the performance measures companies use to manage radical ideas and how do they select them? The fundamental objective of this paper is to address the following research question: What are the processes, MCS, and organizational structures for generating radical innovation? Moreover, in recent years, research on innovation management has been conducted mainly at either the firm level (Birkinshaw, Hamel, & Mol, 2008a) or at the project level examining appropriate management techniques associated with high levels of uncertainty (Burgelman & Sayles, 1988; Dougherty & Heller, 1994; Jelinek & Schoonhoven, 1993; Kanter, North, Bernstein, & Williamson, 1990; Leifer et al., 2000). Therefore, we embarked on a novel process-related research framework to observe the process stages, MCS, and organizational structures that can generate radical innovation. This article is based on a case study at Alcan Engineered Products, a division of a multinational company provider of lightweight material solutions. Our observations suggest that incremental and radical innovation should be managed through different processes, MCS and organizational structures that ought to be activated and adapted contingent to the type of innovation that is being pursued (i.e. incremental or radical innovation). More importantly, we conclude that radical can be generated in a systematic way through enablers such as processes, MCS, and organizational structures. This is in line with the findings of Jelinek and Schoonhoven (1993) and Davila et al. (2006; 2007) who show that innovative firms have institutionalized mechanisms, arguing that radical innovation cannot occur in an organic environment where flexibility and consensus are the main managerial mechanisms. They rather argue that radical innovation requires a clear organizational structure and formal MCS.

« Registre de Mr Pinard, secretaire d'Estat, de la negociation pour traicter le mariage de Monseigneur, filz de France, duc d'Anjou et d'Alençon, frere unique de Henry troisme, avec Elisabeth, reine d'Angleterre ».

Contient : 1 « Pouvoir du roy... HENRY [III]... à messieurs ses commissaires y desnommez, pour aller en Angleterre traicter des moiens du mariaige d'entre la royne dudict pays et monseigneur le duc d'Anjou, frere unicque dudict Sr roy... Donné à St Germain en Laye, le dernier jour de febvrier... mil cinq cens quatre vingtz et ung » ; 2 « Memoire et instruction baillée par le roy ausdits Srs commissaires et ambassadeurs... Faict à St Germain en Laye, le dernier jour de janvier. Signé : Henry, Caterine et Brulart » ; 3 « Lettre du roy à la royne d'Angleterre [Élisabeth]... Escript à St Germain en Laye, le dernier jour de febvrier 1581 » ; 4 Lettre « de la royne, mere du roy, à la dicte dame, royne d'Angleterre... Escript à Blois, le premier jour de mars 1581 » ; 5 Lettre « du roy... HENRY [III]... à la royne d'Angleterre... Escript à Paris, le Ve jour de mars 1581 » ; 6 Lettre « de la royne, mere du roy... CATERINE [DE MEDICIS]... à la royne d'Angleterre... Escript à Blois, le XXVe jour de febvrier 1581 » ; 7 Lettre des ambassadeurs de Henri III « à monsieur de Mauvissiere, ambassadeur pour le roy en Angleterre... De Callais, le XXIe jour de mars 1581 » ; 8 Lettre des ambassadeurs « au roy... Escript à Callais, le XXIIe jour de mars 1581 » ; 9 Lettre des ambassadeurs « à la royne, mere du roy... De Callais, le XXIIe jour de mars 1581 » ; 10 Lettre des ambassadeurs « à monsieur le prince Daulphin [François de Montpensier]... De Callais, le XXIIe jour de mars 1581 » ; 11 « Sauf conduict de la royne d'Angleterre » pour les ambassadeurs envoyés auprès d'elle par le roi de France, en vue du mariage de son frère, le duc d'Anjou, avec Élisabeth. « E pallatio nostro Westmonasteriensi, 12° die martii, anno Domini 1581 ». En latin ; 12 Lettre des ambassadeurs « au roy... De Callais, le XXVIIe jour de mars 1581 » ; 13 Lettre des ambassadeurs « à la royne, mere du roy... De Callais, le XXVIIe jour de mars 1581 » ; 14 Lettre des ambassadeurs « à monseigneur [François, duc d'Anjou]... De Callais, le XXVIIe jour de mars 1581 » ; 15 Lettre des ambassadeurs « à Mr de Mauvissiere,... De Callais, le XXIXe jour de mars 1581 » ; 16 Lettre des ambassadeurs « au roy... De Callais, le XXIXe jour de mars 1581 » ; 17 Lettre des ambassadeurs « à la royne, mere du roy... De Callais, le XXIXe jour de mars 1581 » ; 18 Lettre des ambassadeurs « à Monseigneur... De Callais, le XXIXe jour de mars 1581 » ; 19 Lettre des ambassadeurs « au roy... De Callais, le IIIe jour d'avril 1581 » ; 20 Lettre des ambassadeurs « à la royne, mere du roy... De Callais, le IIIe jour d'avril 1581 » ; 21 Lettre des ambassadeurs « au roy... De Douvre, le XVIIe jour d'avril 1581 » ; 22 Lettre des ambassadeurs « à la royne, mere du roy... De Douvre, le XVIIe jour d'avril 1581 » ; 23 « Ordonnance publiée de par la royne d'Angleterre » pour défendre sous peine de mort les disputes et querelles à main armée pendant toute la durée du séjour des ambassadeurs de France dans son royaume. « Donné au manoir de St James, le XVIIIe jour d'avril 1581 » ; 24 « Ordonnance de monsieur le prince Daulphin [FRANÇOIS DE MONTPENSIER] et messrs les autres commissaires » faisant connaître à toutes les personnes de l'ambassade, l'ordonnance susdite de la reine d'Angleterre ; 25 Lettre des ambassadeurs « au roy... De Londres, le sabmedi XXIIe jour d'apvril 1581 » ; 26 Lettre des ambassadeurs « à la royne, mere du roy... De Londres, le XXIIe jour d'avril 1581 » ; 27 Lettre des ambassadeurs « au roy... De Londres, le XXVe jour d'avril 1581 » ; 28 Lettre des ambassadeurs « à la royne, mere du roy... De Londres, le XXVe jour d'avril 1581 » ; 29 « Discours envoyé au roy et à monseigneur son frere, avec la de pesche de messrs le prince Dauphin [FRANÇOIS DE MONTPENSIER] et autres commissaires, du XXVe d'avril 1581 », sur la suite des négociations, depuis le 24 avril jusqu'au 1er mai de la même année ; 30 Discours du « president BRISSON » aux seigneurs anglais députés par la reine Élisabeth ; 31 Lettre des ambassadeurs « au roy... De Londres, le sabmedy XXIXe jour d'avril 1581 » ; 32 Lettre des ambassadeurs « à la royne, mere du roy... De Londres, le XXIXe jour d'avril 1581 » ; 33 Lettre des ambassadeurs « au roy... De Londres, le mardi IIe jour de may 1581 » ; 34 Lettre des ambassadeurs « à la royne, mere du roy... De Londres, le mardi IIe jour de may 1581 » ; 35 Lettre des ambassadeurs « à monseigneur... [le duc D'ALENÇON]... De Londres, le mardi IIe jour de may 1581 » ; 36 « Pouvoir de la royne d'Angleterre » ÉLISABETH à Guillaume Cecile, Sr de Burle, grand trésorier d'Angleterre, Édouard, comte de Clinton, grand amiral d'Angleterre, Thomas, comte de Sussex, François, comte de Bedfort, Robert, comte de Leicestre, Christophe Hatton et François de Walsingham, commis et députés par elle pour traiter avec les ambassadeurs du roi de France. « E pallatio nostro Westmonasteriensi, secundo die mensis maii, anno... millesimo quingentesimo octuagesimo primo ». En latin ; 37 « Version en françois du susdict pouvoir » ; 38 Lettre des ambassadeurs « au roy... De Londres, le dimanche VIIe jour de may 1581 » ; 39 Lettre des ambassadeurs « à la royne, mere du roy... Dudit jour de dimanche » ; 40 Lettre des ambassadeurs « au roy... De Londres, le venredi XIIe jour de may 1581 » ; 41 Lettre des ambassadeurs « à monseigneur [le duc D'ALENÇON]... De Londres, le vendredi XIIe jour de may 1581 » ; 42 Lettre des ambassadeurs « à la royne, mere du roy... Dudit Londres, ledit jour XIIe may 1581 » ; 43 Résolutions des ambassadeurs du roi de France. « Le XIIe may, à Londres ». Accompagnées d'observations des commissaires de la reine d'Angleterre. « Du XIIIe may 1581 » ; 44 Lettre des ambassadeurs « au roy... De Londres, le sabmedy XIIIe jour de may 1581 » ; 45 Lettre des ambassadeurs « au roy... De Londres, le sabmedi XXe jour de may 1581 » ; 46 Lettre des ambassadeurs « à monseigneur [le duc D'ALENÇON]... Dudit jour XXe may 1581 » ; 47 Lettre des ambassadeurs « à la royne, mere du roy... De Londres, le XXe may 1581 » ; 48 Lettre des ambassadeurs « au roy... De Londres, le dimanche XXIe jour de may 1581 » ; 49 Lettre des ambassadeurs « à la royne, mere du roy... De Londres, le XXIe may 1581 » ; 50 Lettre des ambassadeurs « au roy... De Londres, le venredy XXVIe jour de may 1581 » ; suivie d'un « postscript... Dudict Londres, le sabmedy XXVIIe jour de may 1581 » ; 51 Lettre des ambassadeurs « à la royne, mere du roy... De Londres, le venredi XXVIe jour de may 1581 » ; 52 Lettre de PINART « à Mr Brulart [secrétaire d'État]... De Londres, le premier jour de juin 1581 » ; 53 Lettre des ambassadeurs « à Monseigneur, frere du roi [le duc D'ALENÇON]... De Londres, le premier jour de juin 1581 » ; 54 Lettre des ambassadeurs « au roy... De Londres, le mercredi septme jour de juin 1581 » ; 55 Lettre des ambassadeurs « à Monseigneur » ; 56 Lettre des ambassadeurs « à la royne, mere du roy... De Londres, le mercredi VIIe jour de juin 1581 » ; 57 Lettre des ambassadeurs « au roy... De Londres, le XIIIIe jour de juin 1581 » ; 58 Lettre des ambassadeurs « à la royne, mere du roy... De Londres, le XIIIIe juin 1581 » ; 59 Contrat de mariage entre le duc d'Anjou et d'Alençon et la reine d'Angleterre. « Actum Londinii, in pallatio Westmonasteriensi, undecima die mensis junii, anno... milesimo quingentesimo octuagesimo primo ». En latin ; 60 Lettre de commission du roi « HENRY » III à « Loïs de Bourbon, conte de Soisons, Loïs de Bourbon, duc de Montpensier,... François de Bourbon, prince Daulphin,... Artus de Cossé, conte de Segondigni,... Louys de Lusignan de St Gelez, Sr de Lanssac et de Precy,... Tannegui le Veneur, Sr de Carouges,... Bertrand de Sallignac, Sr de La Mote Fenelon,... Michel de Castelnau, Sr de Mauvissiere,... Barnabé Brisson, Sr de Gravelle,... Claude Pinart, Sr de Cramailles,... Pierre Clausse, Sr de Marchaumont et de Couzances,... Jacques de Vray, Sr de Fontorte », pour traiter du mariage du duc d'Anjou. « Donné à St Germain en Laye, le dernier jour de febvrier... 1581 » ; 61 Lettres de commission de « FRANÇOIS,... duc D'ANJOU » et D'« ALLENÇON », pour les députés choisis par le roi. « Données à Bordeaulx, le XXIIIIe jour de janvier... mil V.C.IIII.XX.I » ; 62 Lettres patentes de « FRANÇOIS,... duc D'ANJOU » et D'« ALLENÇON », confirmant les lettres précédentes. « Données à Allençon, le XVIIIe jour de may, l'an mil cinq cens quatre vingtz et ung » ; 63 Double du numéro 36 ; 64 Lettre « du roy » HENRI III à « monseigneur de Mauvissiere,... Escript à Paris, le XIe jour de janvier 1583 » ; 65 Lettre « de la royne, mere du roy », à « monseigneur de Mauvissiere,... Escript à Paris, le XIe jour de janvier 1583 » ; 66 Lettre « du roy » à « monseigneur de Mauvissiere,... Escript à Paris, le XXVIIe jour de janvier 1583 » ; 67 Lettre « de la royne, mere du roy », à « monseigneur de Mauvissiere,... Escript à Paris, le XXVIIe jour de janvier 1583 » ; 68 Lettre « du roy à Mr [Bertrand de Salignac] de La Mothe Fenelon [ambassadeur en Angleterre]... Escript à Paris, le XXVIIe jour de janvier 1583 » ; 69 Lettre « de la royne, mere du roy, à Mr de La Mothe Fenelon,... Escript à Paris, le XXVIIe jour de janvier 1583 » ; 70 Lettre « du roy » à « monseigneur de Mauvissiere,... Escript à Paris, le XXVIIIe jour de janvier 1583 » ; 71 Lettre « de la royne, mere du roy », à « monseigneur de Mauvissiere,... Escript à Paris, le XXVIIIe jour de janvier 1583 » ; 72 Lettre « du roy » à « monseigneur de Mauvissiere,... Escript à Paris, le XIIIIe jour de fevrier 1583 » ; 73 Lettre « de la royne, mere du roy », à « monseigneur de Mauvissiere,... Escript à Paris, le XIIIIe jour de fevrier 1583 » ; 74 Lettre « du roy » à « monseigneur de Mauvissiere,... Escript à Paris, le VIIIe jour de mars 1583 » ; 75 « Ordonnance du roy à Mrs les grand prieur de Champagne et president Faulcon, pour veoir et entendre le contenu es requestes... presentées doresnavant à Sa Majesté par Mr l'ambassadeur d'Angleterre et les Angloix... Faict à Paris, le IIIe jour de mars 1583 » ; 76 Lettre « de la royne, mere du roy », à « monseigneur de Mauvissiere,... Escript à Paris, le VIIIe jour de mars 1583 » ; 77 Lettre « du roy » à « monseigneur de Mauvissiere,... Escript à Paris, le Ve jour de may 1583 » ; 78 Lettre « de la royne, mere du roy », à « monseigneur de Mauvissiere,... Escript à Paris, le Ve jour de may 1583 » ; 79 Lettre « du roy » à François de Roncherolles, Sr « de Maineville [ambassadeur en Écosse]... Escript à Paris, le Ve jour de may 1583 » ; 80 Lettre « de la royne, mere du roy », à « monseigneur de Maineville,... Escript à Paris, le Ve jour de may 1583 ». ù Les feuillets sont intervertis. Lire dans l'ordre suivant : 58, 61, 64, 60, 59, 62, 63, 65 ; 81 « Aulcuns Poinctz qui ont esté traictez à la conference faicte par commandement du roy avec monseigneur l'ambassadeur d'Angleterre, par les Srs grand prieur de Champagne, president Faulcon et secretaire Pinart, le dimanche VIIIe may 1585 » ; 82 Lettre « du roy » à « monseigneur de Mauvissiere,... Escript à Paris, le XVIIe jour de may 1583 » ; 83 Lettre « de la royne, mere du roy », à « monseigneur de Mauvissiere,... Escript à Paris, le XVIIe jour de may 1583 » ; 84 Lettre « du roy » à « monseigneur de Mauvissiere,... Escript à St Germain en Laye, le XXIXe jour de may 1583 » ; 85 Lettre « de la royne, mere du roy », à « monseigneur de Mauvissiere,... Escript à St Germain en Laye, le XXIXe jour de may 1583 » ; 86 Lettre « du roy au roy d'Escosse [Jacques VI]... Escript à St Germain en Laie, le XXVIIIe may 1583 » ; 87 Lettre « de la royne, mere du roy, audict Sr roy d'Escosse... Escript à St Germain en Laie, le XXVIIIe jour de may 1583 » ; 88 Lettre « du roy à Mr le conte d'Argyle ; chancelier d'Escosse... Escript à St Germain en Laie, le XXVIIIe jour de may 1583 » ; 89 Lettre « du roy à Mr le conte de Gowrie, grand tresorier d'Escosse... Escript à St Germain en Laye, le XXVIIIe jour de may 1583 » ; 90 Lettre « du roy » à « monseigneur de Mauvissiere,... Escript à Maisieres, le XXVIIIe jour de juin 1583 » ; 91 Lettre « de la royne, mere du roy », à « monseigneur de Mauvissiere,... Escript à Maisieres, ledict jour et an » ; 92 Lettre « du roy au roy d'Escosse... Escript à Maisieres, le XXVIIIe jour de juin 1583 » ; 93 Lettre « du roy » à « monseigneur de Mauvissiere,... Escript à Montceaulx, le XXVe jour de juillet 1583 » ; 94 Lettre « de la royne, mere du roy », à « monseigneur de Mauvissiere,... Escript à Monceaulx, le XXVe juillet 1583 » ; 95 Lettre « de la royne, mere du roy », à « monseigneur de Mauvissiere,... Escript à Paris, le IXe jour d'aoust 1583 » ; 96 Lettre « du roy » à « monseigneur de Mauvissiere,... Escript à Montargis, le XVIe jour d'aoust 1583 » ; 97 Lettre « de la royne, mere du roy », à « monseigneur de Mauvissiere,... Escript à La Fere en Picardie, le XIXe jour d'aoust 1583 » ; 98 Lettre « du roy » à « monseigneur de Mauvissiere,... Escript à St Germain en Laie, le XXe jour d'octobre 1583 » ; 99 Lettre « du roy à la royne d'Angleterre... Escript à St Germain en Laie, le XXVIIe jour d'octobre 1583 » ; 100 Lettre « de la royne [CATERINE DE MEDICIS] à ladicte dame royne d'Angleterre... Escript à St Germain en Laie, le XXVIIe octobre 1583 » ; 101 Lettre « de la royne, mere du roy, à ladicte dame royne d'Angleterre... 1583 » ; 102 « Memoire des pieces et plainctes baillées au roy par Sr HENRY COBHAM, chevalier, ambassadeur de la royne d'Angleterre, ce XXIIIe jour d'octobre 1583 » ; 103 Lettre « du roy » à « monseigneur de Mauvissiere,... Escript à St Germain en Laie, le VIIe novembre 1583 » ; 104 Lettre « du roy » à « monseigneur de Mauvissiere,... Escript à St Germain en Laie, le XVIIIe jour de novembre 1583 ». A la suite un « Postscript », du « XXe novembre 1583 » ; 105 Lettre « du roy » à « monseigneur de Mauvissiere,... Escript à St Germain en Laie, le XXVe jour de novembre 1583 » ; 106 Lettre « de la royne, mere du roy », à « monseigneur de Mauvissiere,... Escript à St Germain en Laie, le XXVe jour de novembre 1583 » ; 107 Lettre « du roy » à « monseigneur de Mauvissiere,... Escript à St Germain en Laie, le XVIIe jour de decembre 1583 » ; 108 Lettre « de la royne, mere du roy », à « monseigneur de Mauvissiere,... Escript à St Germain en Laie, le XVIIe jour de decembre 1583 » ; 109 « Memoire et instruction envoyé audict Sr de Mauvissiere pour se conduire et comporter au voyaige qu'il fera en Escosse... Faict à St Germain en Laie, le XVIIe jour de decembre 1583 » ; 110 Lettre « du roy à la royne d'Angleterre... Escript à St Germain en Laie, le XXe jour de decembre 1583 » ; 111 Lettre « du roy au roy d'Escosse... Escript à St Germain en Laie, le XXe jour de decembre 1583 » ; 112 Lettre « du roy à la royne d'Escosse [Marie Stuart]... Escript à St Germain en laie, le XXe jour de decembre 1583 » ; 113-116 « Quatre Formes de lettres dont en a esté envoié plusieurs audict Sr de Mauvissiere, pour s'en servir... estant en Escosse... Escript à St Germain en Laie, le XXe jour de decembre 1583 » ; 117 « Secrette Lectre du roy » à « monseigneur de Mauvissiere,... Escript à St Germain en Laie, le XVIIIe jour de decembre 1583 » ; 118 Addition à l'instruction de Henri III ci-dessus mentionnée n° 109, pour les « Sr de Mauvissiere et le viconte Pinart, son secretaire » ; 119 Lettre du roi « à la royne d'Angleterre » ; 120 « Aucunes Choses de la depesche que le Sr de La Mothe Fenelon a naguieres rapportée d'Escosse » ; 121 « Arrest donné, les estatz d'Escosse assemblez, pour impugner le couronnement du roy d'Escosse et l'establissement du gouverneur dudict païs... In parlamento serenissimae dominae nostre reginae... in pretorio burgi de Edinburhg, decimo quinto dioe mensis junii 1581 ». ù Les feuillets sont intervertis. Lire dans l'ordre suivant : 80, 82, 81, 84, 83, 85, 86 ; 122 « Declaration du duc de LENOX [EDME STUART I] contre les faulces calomnies à luy imposées par le comte de Mors et lord Revarz, dict le comte de Goury, et leurs confederez... Faict à Domberthrand [Dunbarton], le XXIIe septembre 1582 » ; 123 « Propositions faictes en Escosse par monseigneur de La Mothe Fennellon et les responces à luy faictes » ; 124 « Declaration qui a esté publiée en Escosse... Faict à Halyendehouse, le XIXme jour d'octobre 1582 » ; 125 « Lettre escripte à monsieur [Jérôme] de Gondi par monsieur DE GLASGO, ambassadeur d'Escosse, resident pres du roy » Henri III

Immunologic aspects of West syndrome and evidence of plasma inhibitory effects on T cell function

OBJETIVO: O objetivo deste estudo foi determinar o perfil da deficiência imune em um grupo bem definido de epilepsia: crianças com síndrome de West (SW) e seus padrões EEG de evolução, idade-dependentes, como os complexos onda-aguda- onda lenta generalizadas da síndrome de Lenox-Gastaut (SLG) e as pontas multifocais independentes (PMI). MÉTODO: Um grupo de 50 crianças, 33 com SW, 10 com SLG, 7 com PMI e 20 crianças sadias (controle) foram avaliadas em relação aos seguintes parâmetros:determinação de subpopulações de linfócitos T (CD1, CD3, CD4 e CD8), relação CD4/CD8 e resposta proliferativa de linfócitos frente a fitohemaglutinina (PHA), na presença de plasma autólogo ou de plasma AB (homólogo). A prova cutânea de sensibilização ao Dinitroclorobenzeno (DNCB) foi realizada apenas nos pacientes. Os níveis séricos de IgG, IgA e IgM foram comparados aos valores normais em crianças Brasileiras, em diferentes faixas etárias. RESULTADOS: A resposta ao DNCB foi ausente ou fracamente reativa em 76% dos pacientes. Níveis séricos elevados de IgG (45,7%) e de IgM (61,4%) e baixos de IgA (23,9%) foram detectados nos pacientes. A determinação das subpopulações de linfócitos T em sangue periférico mostrou: deficiência nas proporções de células CD3+ (p<0,05) e de CD4+ (p<0,05), aumento de CD8+ (p<0,01) e diminuição da relação CD4 / CD8 (p<0,001). A proporção de células CD1+ no grupo controle manteve-se menor que 3%, enquanto que em 18% dos pacientes esses níveis variaram entre 3 e 11%. A resposta proliferativa de linfócitos frente a PHA revelou índices blastogênicos significativamente mais baixos apenas quando células dos pacientes foram cultivadas na presença do próprio plasma (plasma autólogo). Quando estas células foram cultivadas na presença de plasma AB, não se evidenciou diferença significativa em relação ao grupo controle. CONCLUSÃO: A imunodeficiência na SW caracterizou-se por: anergia, alteração de imunidade mediada por células e dos níveis de imunoglobulinas, presença de timócitos imaturos na circulação periférica e deficiência funcional de linfócitos T induzida por fatores plasmáticos inibidores. Discutem-se as principais evidências de disfunção imune como imunodeficiência e autoimunidade.

Efficacy of motivational enhancement therapy on alcohol use disorders in patients with chronic hepatitis C: a randomized controlled trial

AIMS: To determine the efficacy of motivational enhancement therapy (MET) on alcohol use in patients with the hepatitis C virus (HCV) and an alcohol use disorder (AUD). DESIGN: Randomized, single-blind, controlled trial comparing MET to a control education condition with 6-month follow-up. SETTING: Patients were recruited from hepatitis clinics at the Minneapolis, Minnesota and Portland, Oregon Veterans Affairs Health Care Systems, USA. PARTICIPANTS AND INTERVENTION: Patients with HCV, an AUD and continued alcohol use (n = 139) were randomized to receive either MET (n = 70) or a control education condition (n = 69) over 3 months. MEASUREMENTS: Data were self-reported percentage of days abstinent from alcohol and number of standard alcohol drinks per week 6 months after randomization. FINDINGS: At baseline, subjects in MET had 34.98% days abstinent, which increased to 73.15% at 6 months compared to 34.63 and 59.49% for the control condition. Multi-level models examined changes in alcohol consumption between MET and control groups. Results showed a significant increase in percentage of days abstinent overall (F(1120.4)  = 28.04, P < 0.001) and a significant group × time effect (F(1119.9)  = 5.23, P = 0.024) with the MET group showing a greater increase in percentage of days abstinent at 6 months compared with the education control condition. There were no significant differences between groups for drinks per week. The effect size of the MET intervention was moderate (0.45) for percentage of days abstinent. CONCLUSION: Motivational enhancement therapy (MET) appears to increase the percentage of days abstinent in patients with chronic hepatitis C, alcohol use disorders and ongoing alcohol use. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.

Effect of reduced myristoylated alanine-rich C kinase substrate expression on hippocampal mossy fiber development and spatial learning in mutant mice: Transgenic rescue and interactions with gene background

The myristoylated alanine-rich C kinase substrate (MARCKS) is a prominent protein kinase C (PKC) substrate in brain that is expressed highly in hippocampal granule cells and their axons, the mossy fibers. Here, we examined hippocampal infrapyramidal mossy fiber (IP-MF) limb length and spatial learning in heterozygous Macs mutant mice that exhibit an ≈50% reduction in MARCKS expression relative to wild-type controls. On a 129B6(N3) background, the Macs mutation produced IP-MF hyperplasia, a significant increase in hippocampal PKCɛ expression, and proficient spatial learning relative to wild-type controls. However, wild-type 129B6(N3) mice exhibited phenotypic characteristics resembling inbred 129Sv mice, including IP-MF hypoplasia relative to inbred C57BL/6J mice and impaired spatial-reversal learning, suggesting a significant contribution of 129Sv background genes to wild-type and possibly mutant phenotypes. Indeed, when these mice were backcrossed with inbred C57BL/6J mice for nine generations to reduce 129Sv background genes, the Macs mutation did not effect IP-MF length or hippocampal PKCɛ expression and impaired spatial learning relative to wild-type controls, which now showed proficient spatial learning. Moreover, in a different strain (B6SJL(N1), the Macs mutation also produced a significant impairment in spatial learning that was reversed by transgenic expression of MARCKS. Collectively, these data indicate that the heterozygous Macs mutation modifies the expression of linked 129Sv gene(s), affecting hippocampal mossy fiber development and spatial learning performance, and that MARCKS plays a significant role in spatial learning processes.

Book of record for actions under $4.00. 1790-1799

Contains a record of cases which came before Egleston in his capacity as a justice of the peace for Berkshire County. The court was held in his home at Lenox.

Chicago and vicinity, Illinois, 1953 (Image 3 of 3) (Raster Image)

This layer is a georeferenced raster image of the historic, topographic paper map entitled: Chicago and vicinity, Ill.-Ind. : sheet no. 3 of 3 (Blue Island), 1953, mapped, edited, and published by the Geological Survey. It was published in 1957. Scale 1:24,000. The source map was compiled from 1:24,000 scale maps of Calumet Lake, Blue Island, Palos Park, Sag Bridge, Mokena, Tinley Park, Harvey, and Calumet City 1953 7.5 minute quadrangles. Hydrography from U.S. Lake Survey Chart 755 (1:15,000). This layer is image 3 of 3 total images of the three sheet source map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Illinois East State Plane Coordinate System NAD27 (in Feet) (Fipszone 1201). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This is a typical topographic map portraying both natural and manmade features. It shows and names works of nature, such as mountains, valleys, lakes, rivers, vegetation, etc. It also identify the principal works of humans, such as roads, railroads, boundaries, transmission lines, major buildings, etc. Relief is shown with standard contour intervals of 5 feet. Depths shown by isolines and soundings. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Berkshire Hills, Massachusetts, railway and highway map, 1883 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Railway and highway map of the famous Berkshire Hills region, showing also villages and points of interest, by Walter Watson, C.E. for the Berkshire Life Insurance Co. of Pittsfield, Mass., 1883. Scale [1:134,376]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as main roads, railroads and railroad stations, drainage, mountains, schools, churches, cemeteries, town boundaries and more. Relief is shown by hachures and spot heights. Includes text and illustrations. This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

Berkshire Hills, Massachusetts, railway and highway map, 1896 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Railway and highway map of the famous Berkshire Hills region : showing also villages and points of interest, by Walter Watson, C.E. for the Berkshire Life Insurance Co. of Pittsfield, Mass., 1883, corrected to 1896. Scale [1:134,376]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as main roads, railroads and railroad stations, drainage, mountains, schools, churches, cemeteries, town boundaries and more. Relief is shown by hachures and spot heights. Includes text and illustrations. This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

Berkshire County, Massachusetts, 1858 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Map of the county of Berkshire, Massachusetts, the details from actual surveys under the direction of Henry F. Walling, supt. of the state map. It was published by Smith, Gallup & Co. in 1858. Scale 1:50,688. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, public buildings, schools, churches, cemeteries, industry locations (e.g. mills, factories, mines, etc.), private buildings with names of property owners, town and county boundaries and more. Relief is shown by hachures. It includes many cadastral insets of individual county towns and villages, and an inset geological map of county. Includes also illustrations, business directories, and tables of statistics and distances. This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.