Joseph T. A. Lee

Original image (attached to acidic board) was photographed and negative created by Lance Burghardt. Photographer of original print unknown

Effect of caffeine on adenosine-induced reversible perfusion defects assessed by automated analysis

Objectives This prospective study investigated the effects of caffeine ingestion on the extent of adenosine-induced perfusion abnormalities during myocardial perfusion imaging (MPI). Methods Thirty patients with inducible perfusion abnormalities on standard (caffeine-abstinent) adenosine MPI underwent repeat testing with supplementary coffee intake. Baseline and test MPIs were assessed for stress percent defect, rest percent defect, and percent defect reversibility. Plasma levels of caffeine and metabolites were assessed on both occasions and correlated with MPI findings. Results Despite significant increases in caffeine [mean difference 3,106 μg/L (95% CI 2,460 to 3,752 μg/L; P < .001)] and metabolite concentrations over a wide range, there was no statistically significant change in stress percent defect and percent defect reversibility between the baseline and test scans. The increase in caffeine concentration between the baseline and the test phases did not affect percent defect reversibility (average change −0.003 for every 100 μg/L increase; 95% CI −0.17 to 0.16; P = .97). Conclusion There was no significant relationship between the extent of adenosine-induced coronary flow heterogeneity and the serum concentration of caffeine or its principal metabolites. Hence, the stringent requirements for prolonged abstinence from caffeine before adenosine MPI—based on limited studies—appear ill-founded.

Anti-Semitism in the United States : its history and causes

by Lee J. Levinger

Modification of EWS/WT1 functional properties by phosphorylation

In many human cancers, tumor-specific chromosomal rearrangements are known to create chimeric products with the ability to transform cells. The EWS/WT1 protein is such a fusion product, resulting from a t(11;22) chromosomal translocation in desmoplastic small round cell tumors, where 265 aa from the EWS amino terminus are fused to the DNA binding domain of the WT1 tumor suppressor gene. Herein, we find that EWS/WT1 is phosphorylated in vivo on serine and tyrosine residues and that this affects DNA binding and homodimerization. We also show that EWS/WT1 can interact with, and is a substrate for, modification on tyrosine residues by c-Abl. Tyrosine phosphorylation of EWS/WT1 by c-Abl negatively regulates its DNA binding properties. These results indicate that the biological activity of EWS/WT1 is closely linked to its phosphorylation status.

Sermon : manuscript, 1768

Sermon on John 15:1-2.

Local public works administration in Michigan,

"A report to the Commission of inquiry, Lent D. Upson, director of inquiry, February, 1934."

Ballads of battle,

Printed in Great Britain.

Bibliography of low energy electron and photon cross section data (through December 1974) /

Includes index.

Carmilla e Sabella: em busca de uma identidade feminina em Joseph Sheridan Le Fanu e Tanith Lee

Pós-graduação em Letras - IBILCE

Reports of cases argued and determined in the Arches and Prerogative Courts of Canterbury, and in the High Court of Delegates : containing judgments of the Right Hon. Sir George Lee /

Title on spine: Lee Arches & Prerogative Courts.

Memoirs of Robert E. Lee; his military and personal history, embracing a large amount of information hitherto unpublished,

The appendix (p. 501-699) contains many reports, lists, etc., relating to the Army of northern Virginia.