736 resultados para Laredo, Bernardino de.


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Mode of access: Internet.

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The Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic defect in the world. The most common clinical manifestations are acute hemolytic anemia associated with drugs, infections, neonatal jaundice and hemolytic non-spherocytic chronic anemia. The main aim of this study was to determine the frequency of major genetic variants of G6PD leading to enzyme deficiency in children from 0 to 14 years at a Pediatric Hospital in Luanda, Angola. A cross-sectional and descriptive analytical study covered a total of 194 children aged from 0 to 14 years, of both genders and hospitalized at the Pediatric Hospital David Bernardino, Luanda between November and December, 2011. The G202A, A376G and C563T mutations of the G6PD gene were determined by real-time PCR with Taqman probes. The disabled A-/A- genotype was detected in 10 girls (10.9%). Among the boys, 21 (20.6%) presented the genotype A-. Considering all the samples, the A- variant was observed in 22.4% of cases. The Mediterranean mutation was not detected in the Angolan sample. Furthermore, no association was found between genotype and anemia, nutritional state and mucosa color. A significant association, however, was observed with jaundice. Based on the results obtained, there is a clear need to identify those with the disabled genotype in the Angolan population in order to avoid cases of drug-induced anemia, particularly in the treatment of malaria, so prevalent in Angola.

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Dissertação apresentada para cumprimento dos requisitos necessários à obtenção do grau de Mestre em História Moderna e dos Descobrimentos

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Dissertação para obtenção do Grau de Mestre em Ensino de Matemática no 3o Ciclo do Ensino Básico e no Secundário

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Référence bibliographique : Weigert, 331

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Saisi en 1798 de la bibliothèque de la famille Albani à Rome; cf. B.n.F., département des Manuscrits, Archives Modernes 520; Laffitte, Bulletin du Bibliophile, 1989/2, 309.

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Tesis (Maestría en Enfermeria con Especialidad en Salud Comunitaria) UANL

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Tesis (Maestría en Ciencias de Enfermería con Énfasis en Salud Comunitaria) UANL

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Tesis (Maestría en Ciencias de la Administración con Especialidad en Sistemas) U.A.N.L. Facultad de Ingeniería Mecánica y Eléctrica, 1999.

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Tesis (Maestría en Ciencias de la Administración con Especialidad en Sistemas) U.A.N.L.

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Tesis (Maestría en Ciencias de la Administración con Especialidad en Relaciones Industriales) U.A.N.L.

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Tesis (Maestría en Ciencias de la Administración con Especialidad en Sistemas) U.A.N.L.

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Tesis (Maestría en Ciencias de la Administración con Especialidad en Sistemas) U.A.N.L. Facultad de Ingeniería Mecánica Eléctrica.