122 resultados para LDE
Resumo:
Digital reproduction, The National Library of Finland, Centre for Preservation and Digitisation, Mikkeli
Resumo:
Acute myelogenous leukemia (AML) blast cells show high-affinity degradation of low-density lipoprotein (LDL), suggesting an increased expression of cellular LDL receptors. LDE is a lipid microemulsion easily synthesized in vitro which is known to mimic the metabolic pathway of LDL. We used LDE as a carrier for daunorubicin and assayed the cytotoxicity of the complex using AML blast cells since RT-PCR analysis showed that AML cells express LDL receptor mRNA. The LDE:daunorubicin complex killed 46.7% of blast cells and 20.2% of normal bone marrow cells (P<0.001; Student t-test). Moreover, this complex destroyed AML blast cells as efficiently as free daunorubicin. Thus, LDE might be a suitable carrier of chemotherapeutic agents targeting these drugs to neoplastic cells and protecting normal tissues.
Resumo:
Cover title.
Resumo:
Includes index.
Resumo:
Mode of access: Internet.
Resumo:
Mode of access: Internet.
Resumo:
Mode of access: Internet.
Resumo:
Mode of access: Internet.
Resumo:
Mode of access: Internet.
Resumo:
Includes index.
Resumo:
"Vorbemerkung" signed: E. Waldmann.
Resumo:
Mode of access: Internet.
Resumo:
Includes index.
Resumo:
"Verschiedene Werke, no. 43"
Resumo:
"Die folgenden Untersuchungen haben im Sommer ... 1908 ... der Universität Halle in lateinischer Sprache als Doktordissertation vorgelegen, und ihre drei ersten Kapital sind unter dem Titel 'Qua ratione pictores Pompeiani in componendis parietibus usi sint' als Dissertation gedruckt worden."--Vorwort.