A rebel war clerk's diary at the Confederate States capital /

Reprint. Originally published: Philadelphia : Lippincott, 1866.

A rebel war clerk's diary at the Confederate States capital /

Mode of access: Internet.

A Rebel war clerk's diary at the Confederate States capital,

Mode of access: Internet.

III. Biographical notes on John Stark, [1810 March]

One leaf containing a page of handwritten biographical notes on Revolutionary War hero General John Stark in Bentley's hand. The note is written on the verso of a short letter from J. Pitcairn regarding a deliver for the "Rev. D. Bently" dated March 2, 1810. The notes were likely copied from the biographical sketch published in the Essex Register May 1, 1810.

My life and times, 1810-1899 /

Mode of access: Internet.

Late Mogollon pottery types of the Reserve area / John B. Rinaldo, Assistant Curator, Archaeology, and Elaine A. Bluhm, Assistant, Archaeology.

v.36:no.7(1956)

An analysis of culture change in the Ackmen-Lowry area / John B. Rinaldo, Assistant, Archaeology.

v.36:no.5(1950)

Excavations in the upper Little Colorado drainage, eastern Arizona / [by] Paul S. Martin [and] John B. Rinaldo.

v.51:no.1(1960)

Reports of the Princeton University Expeditions to Patagonia, 1896-1899 : J.B. Hatcher in charge /

At head of title: J. Pierpont Morgan Publication Fund.

Some descriptions of the battles in which the commands of Gen. John B. Sanborn, of St. Paul, Minnesota, participated in the departments of Tennessee and Missouri during the rebellion of 1861-65.

Mode of access: Internet.

A report of the evidence and points of law, arising in the trial of John Francis Knapp, for the murder of Joseph White, esquire.

Mode of access: Internet.

Gender differences in earnings among young adults entering the labor market / Suzanne B. Clery, John B. Lee, Laura G. Knapp.

"NCES 98-086."

Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumour-burdened lymph nodes after intravenous and subcutaneous administration in rats

The current study sought to explore whether the subcutaneous administration of lymph-targeted dendrimers, conjugated with a model chemotherapeutic (methotrexate, MTX), was able to enhance anticancer activity against lymph node metastases. The lymphatic pharmacokinetics and antitumour activity of PEGylated polylysine dendrimers conjugated to MTX [D-MTX(OH)] via a tumour-labile hexapeptide linker was examined in rats and compared to a similar system where MTX was α-carboxyl O-tert-butylated [D-MTX(OtBu)]. The latter has previously been shown to exhibit longer plasma circulation times. D-MTX(OtBu) was well absorbed from the subcutaneous injection site via the lymph, and 3 to 4%/g of the dose was retained by sentinel lymph nodes. In contrast, D-MTX(OH) showed limited absorption from the subcutaneous injection site, but absorption was almost exclusively via the lymph. The retention of D-MTX(OH) by sentinel lymph nodes was also significantly elevated (approximately 30% dose/g). MTX alone was not absorbed into the lymph. All dendrimers displayed lower lymph node targeting after intravenous administration. Despite significant differences in the lymph node retention of D-MTX(OH) and D-MTX(OtBu) after subcutaneous and intravenous administration, the growth of lymph node metastases was similarly inhibited. In contrast, the administration of MTX alone did not significantly reduce lymph node tumour growth. Subcutaneous administration of drug-conjugated dendrimers therefore provides an opportunity to improve drug deposition in downstream tumour-burdened lymph nodes. In this case, however, increased lymph node biodistribution did not correlate well with antitumour activity, possibly suggesting constrained drug release at the site of action.

Elisha B. Sherwood letter, February 26, 1845

Elisha Barber Sherwood (1810-1905) was a Presbyterian minister. He began his career as a minister in the Church at Wilson, Niagara County, N.Y., subsequently becoming pastor at various churches in New York, Michigan, and Missouri. He is the author of Fifty Years on the Skirmish Line, a review of his ministerial work.