A record of the Searight family, (also written Seawright). Established in America by William Seawright, who came from near Londonderry ... to Lancaster County, Pennsylvania, about 1740; with an account of his descendants as far as can be ascertained.

Photocopy.

Plan for fish ponds; estate of Mr. James A. Allison

Black and red ink on linen; some pencil. Location of ponds, buildings and gardens; elevations; two cross-section details of pond depth and drainage; some penciled topographical lines, elevations and changes in location of buildings, walkways and ponds. 93 cm. x 57 cm. [Marion College] [from photographic copy by Lance Burgharrdt]

Topographical survey; grounds of Mr. James A. Allison

Ink on linen. Elevations, location of drainage tiles, buildings and vegetation. Includes some penciled lines and notes. 94 cm. x 80 cm. Scale: 1"= 50' [Marion College] [from photographic copy by Lance Burgharrdt]

Design for boulder bridge; grounds of Mr. James A. Allison

Red and black ink on linen. View from top, side and end elevations and cross-section with distances and grades. 111 cm. x 50 cm. Scale: 1/4" = 1'. Signed. [Marion College] [from photographic copy by Lance Burgharrdt]

Topographical survey; grounds of Mr. James A. Allison

Black and red ink on linen. Elevations, topographical lines, location of vegetation, buildings and drainage tiles; locations of (proposed?) gardens, walkways, ponds, stables, etc. penciled in. 92 cm. x 83 cm. Scale: 1" = 50'. [Marion College] [from photographic copy by Lance Burgharrdt]

General plan; grounds of Mr. James A. Allison

Pencil and red ink on linen. Indicates location of buildings, ponds, gardens, vegetation, sewers, etc. Signed. 92 cm x 84 cm. Scale: 1" = 50'. Signed. [Marion College] [from photographic copy by Lance Burgharrdt]

Planting plan for gardens; estate of Mr. James A. Allison

Red and black ink on linen. Instructions on location, type and amount of vegetation. Signed. 103 cm. x 88 cm. Scale: 1" = 20'. Signed. [Marion College] [from photographic copy by Lance Burgharrdt]

Plan showing location of tennis court, vegetable garden and walls, and grounds of James A. Allison

Pencil on linen. Elevations for walls and gates. Signed. 106 cm. x 27 cm. Scale: 1" = 20'. [Marion College] [from photographic copy by Lance Burgharrdt]

The Genetic Landscape of the Childhood Cancer Medulloblastoma

Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high-density microarrays and sequenced all known protein-coding genes and microRNA genes using Sanger sequencing in a set of 22 MBs. We found that, on average, each tumor had 11 gene alterations, fewer by a factor of 5 to 10 than in the adult solid tumors that have been sequenced to date. In addition to alterations in the Hedgehog and Wnt pathways, our analysis led to the discovery of genes not previously known to be altered in MBs. Most notably, inactivating mutations of the histone-lysine N-methyltransferase genes MLL2 or MLL3 were identified in 16% of MB patients. These results demonstrate key differences between the genetic landscapes of adult and childhood cancers, highlight dysregulation of developmental pathways as an important mechanism underlying MBs, and identify a role for a specific type of histone methylation in human tumorigenesis.

James Parkinson (1755-1824): A pioneer of child care

James Parkinson (1755-1824) of Parkinson's disease, is well recognized as a pioneer of clinical neurology; and is even more famous as a founder of modem palaeontology. We have reviewed from primary sources his extensive contributions to clinical child care and his pioneering advocacy for child welfare, protection and safety. His writings, outreach and advocacy for children's health characterizes him as one whose influence was an important springboard from which evolved the modern specialty of paediatrics. Parkinson was one of the first to write on child-rearing practices and in this context antedated Benjamin Spock by 150 years. Parkinson was a pioneer of child safety and the prevention of childhood trauma. He wrote of the resuscitation of near-drowned children and of first aid for injured children. This critical analysis reviews his pioneering description of child abuse and the development of post-abuse hydrocephalus. He wrote the datum description (in English) of the pathophysiology and pathology of appendicitis in children, of fatal rabies in children and highlighted the risk of death even when the biting dog was not clinically rabid. His advocacy for social reform for children's welfare was courageous and pioneering. James Parkinson, hitherto unacknowledged, was a significant founder of the evolving discipline of paediatrics and child health.

Birth weight, weight change, and blood pressure during childhood and adolescence: a school-based multiple cohort study.

OBJECTIVE: We assessed the association between birth weight, weight change, and current blood pressure (BP) across the entire age-span of childhood and adolescence in large school-based cohorts in the Seychelles, an island state in the African region. METHODS: Three cohorts were analyzed: 1004 children examined at age 5.5 and 9.1 years, 1886 children at 9.1 and 12.5, and 1575 children at 12.5 and 15.5, respectively. Birth and 1-year anthropometric data were gathered from medical files. The outcome was BP at age 5.5, 9.1, 12.5 or 15.5 years, respectively. Conditional linear regression analysis was used to estimate the relative contribution of changes in weight (expressed in z-score) during different age periods on BP. All analyses were adjusted for height. RESULTS: At all ages, current BP was strongly associated with current weight. Birth weight was not significantly associated with current BP. Upon adjustment for current weight, the association between birth weight and current BP tended to become negative. Conditional linear regression analyses indicated that changes in weight during successive age periods since birth contributed substantially to current BP at all ages. The strength of the association between weight change and current BP increased throughout successive age periods. CONCLUSION: Weight changes during any age period since birth have substantial impact on BP during childhood and adolescence, with BP being more responsive to recent than earlier weight changes.