Altered JS-2 expression in colorectal cancers and its clinical pathological relevance

JS-2 is a novel gene located at 5p15.2 and originally detected in primary oesophageal cancer. There is no study on the role of JS-2 in colorectal cancer. The aim of this study is to determine the gene copy number and expression of JS-2 in a large cohort of patients with colorectal tumours and correlate these to the clinicopathological features of the cancer patients. We evaluated the DNA copy number and mRNA expression of JS-2 in 176 colorectal tissues (116 adenocarcinomas, 30 adenomas and 30 non-neoplastic tissues) using real-time polymerase chain reaction. JS-2 expression was also evaluated in two colorectal cancer cell lines and a benign colorectal cell line. JS-2 amplification was noted in 35% of the colorectal adenocarcinomas. Significant differences in relative expression levels for JS-2 mRNA between different colorectal tissues were noted (p = 0.05). Distal colorectal adenocarcinoma had significantly higher copy number than proximal adenocarcinoma (p = 0.005). The relative expression level of JS-2 was different between colonic and rectal adenocarcinoma (p = 0.007). Mucinous adenocarcinoma showed higher JS-2 expression than non-mucinous adenocarcinoma (p = 0.02). Early T-stage cancers appear to have higher JS-2 copy number and lower expression of JS-2 mRNA than later stage cancers (p = 0.001 and 0.03 respectively). Colorectal cancer cell lines showed lower expression of JS-2 than the benign colorectal cell line. JS-2 copy number change and expression were shown for the first time to be altered in the carcinogenesis of colorectal cancer. In addition, genetic alteration of JS-2 was found to be related to location, pathological subtypes and staging of colorectal cancer.

Aggregazione di dati con gestione a eventi su Node JS

L'obbiettivo di questa tesi è dimostrare che è attualmente possibile realizzare un sistema di aggregazione dati in grado di gestire un numero elevato di connessioni contemporanee con relativamente poco sforzo per lo sviluppatore grazie all'utilizzo di Node JS, piattaforma che utilizza internamente una gestione a eventi a livello di linguaggio di programmazione.

Server-side scripting: confronto fra PHP, Python e server-side JS integrato in NodeJs

Lo scopo della tesi è quello di descrivere e mettere a confronto tre diversi linguaggi, e quindi approcci, alla programmazione server-side e di back-end, ovvero il linguaggio PHP, il linguaggio Python ed il linguaggio Javascript, utilizzato però per una programmazione “Server Side”, e quindi associato al framework NodeJS. Questo confronto si pone l’obiettivo di sottolineare le differenti caratteristiche di ogni linguaggio, gli scopi a cui esso maggiormente si addice e di fornire una sorta di guida per far in modo che si possa comprendere al meglio quale dei tre linguaggi maggiormente usati per la programmazione backend si conformi meglio all’obiettivo prepostosi.

FS.js, una libreria file system per Node.js e HTML5

La tesi illustra le funzionalita e l'architettura di Node.js elencando e analizzando le caratteristiche che lo rendono un framework vincente nella sfida che il web attuale pone. La tesi comprende l'analisi e la descrizione del lavoro svolto per creare una libreria HTTP/ File system, integrata nel sistema di sviluppo cloud proprietario: Instant Developer , funzionante sia su Node.JS che sui browser che supportano appieno le nuove API File system di HTML 5. Particolare attenzione viene riservata per la descrizione della struttura della libreria, pensata per permettere all'utente dell'IDE di utilizzarla indifferentemente su server/browser senza preoccuparsi di chiamare metodi diversi. Fs.js permette di operare con file/cartelle, richieste HTTP in modo semplificato rispetto alle API Ufficiali dei rispettivi ambienti.

Unmaßgebliche Vorschläge, als Instruktion für den Herrn Sattlermeister Georg Hollenbach, Abgeordneter der mittelfränkischen Kreishauptstadt Ansbach, zu der am 15. Juli d. Js. in Frankfurt a/M. zusammentretenden Versammlung deutscher Gewerbetreibenden ertheilt: Bei der Besprechung des Comité's für die Gewerbs-Congreßbeschickung zu Frankfurt ...

Welsch (Projektbearbeiter): Verhaltensmaßregeln für den als Vertreter Ansbachs in den 'Deutschen Handwerker- und Gewerbe-Congreß' nach Frankfurt entsandten Sattlermeister Hollenbach

Studententhum und Centralverein : Vortrag, gehalten in der Central-Vereins-Versammlung am 23. Juni ds. Js.

M. Horwitz

Bericht über die vom 16. April bis 20. Mai ds. Js. in der Anstalt eingegangenen Meldungen der Auskunftsstellen für Pflanzenschutz und deren Vertrauensmänner

Hiltner

Aplicación web de gestión financiera personal desarrollada con MEAN.JS

En este trabajo de fin de grado se llevará a cabo la elaboración de una aplicación web de gestión de gastos personales desde sus inicios, hasta su completo funcionamiento. Estas aplicaciones poseen un crecimiento emergente en el mercado, lo cual implica que la competencia entre ellas es muy elevada. Por ello el diseño de la aplicación que se va a desarrollar en este trabajo ha sido delicadamente cuidado. Se trata de un proceso minucioso el cual aportará a cada una de las partes de las que va a constar la aplicación características únicas que se plasmaran en funcionalidades para el usuario, como son: añadir sus propios gastos e ingresos mensuales, confeccionar gráficos de sus principales gastos, obtención de consejos de una fuente externa, etc… Estas funcionalidades de carácter único junto con otras más generalistas, como son el diseño gráfico en una amplia gama de colores, harán su manejo más fácil e intuitivo. Hay que destacar que para optimizar su uso, la aplicación tendrá la característica de ser responsive, es decir, será capaz de modificar su interfaz según el tamaño de la pantalla del dispositivo desde el que se acceda. Para su desarrollo, se va a utilizar una de las tecnologías más novedosas del mercado y siendo una de las más revolucionarias del momento, MEAN.JS. Con esta innovadora tecnología se creará la aplicación de gestión económica de gastos personales. Gracias al carácter innovador de aplicar esta tecnología novedosa, los retos que plantea este proyecto son muy variados, desde cómo estructurar las carpetas del proyecto y toda la parte de backend hasta como realizar el diseño de la parte de frontend. Además una vez finalizado su desarrollo y puesta en marcha se analizaran posibles mejoras para poder perfeccionarla en su totalidad. ABSTRACT In this final degree project will take out the development of a web application from its inception, until its full performance management. These applications have an emerging market growth, implying that competition between them is very high. Therefore the design of the application that will be developed in this work has been delicately care. It's a painstaking process which will provide each of the parties which will contain the application unique features that were translated into functionality for the user, such as: add their own expenses and monthly income, make graphs of your major expenses, obtaining advice from an external source, etc... These features of unique character together with other more general, such as graphic design in a wide range of colors, will make more easy and intuitive handling. It should be noted that to optimize its use, the application will have the characteristic of being responsive, will be able to modify your interface according to the size of the screen of the device from which are accessed. For its development, it is to use one of the newest technologies on the market and being one of the most revolutionary moment, MEAN. JS. The economic management of personal expenses application will be created with this innovative technology. Thanks to the innovative nature of applying this new technology, the challenges posed by this project are varied, from how to structure the folders of the project and all the backend part up to how to perform the part of frontend design. In addition once finished its development and commissioning possible improvements will analyze to be able to perfect it in its entirety.

Development of a Dashboard for Sentiment Analysis of Football in Twitter based on Web Components and D3.js

This thesis is the result of a project whose objective has been to develop and deploy a dashboard for sentiment analysis of football in Twitter based on web components and D3.js. To do so, a visualisation server has been developed in order to present the data obtained from Twitter and analysed with Senpy. This visualisation server has been developed with Polymer web components and D3.js. Data mining has been done with a pipeline between Twitter, Senpy and ElasticSearch. Luigi have been used in this process because helps building complex pipelines of batch jobs, so it has analysed all tweets and stored them in ElasticSearch. To continue, D3.js has been used to create interactive widgets that make data easily accessible, this widgets will allow the user to interact with them and �filter the most interesting data for him. Polymer web components have been used to make this dashboard according to Google's material design and be able to show dynamic data in widgets. As a result, this project will allow an extensive analysis of the social network, pointing out the influence of players and teams and the emotions and sentiments that emerge in a lapse of time.