IPA-kyselylomake valinnoista ja osallistumisesta jokapäiväisessä elämässä. Toimintakyvyn itsearviointimenetelmä aikuisille, joilla on fyysisiä toimintarajoitteita

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The symbolization of central approximants in the IPA

Approximants that can be considered weaker versions of voiced fricatives (termed here ‘frictionless continuants’) are poorly served by the IPA in terms of symbolization as compared to semi-vowel approximants. In this paper we survey the central approximants and the symbols and diacritics used to transcribe them; we focus on evidence for the use of non-rhotic frictionless continuants in both natural language (by which we mean non-clinical varieties) and disordered speech; and we suggest some possible unitary symbols for those that currently require the use of a hard-to-read lowering diacritic beneath the symbol for the corresponding voiced fricative.

El proyecto de innovación de Amsterdam (IPA).

Se desarrolla el Proyecto de Innovación de Ámsterdam (IPA), llevado a cabo en 1971 con el objeto de disminuir los problemas que los hijos de los trabajadores experimentan en la enseñanza, y aumentar sus posibilidades de desarrollo. Su duración fue de siete años y en él participaron: juntas escolares, personal docente, alumnos y padres de escuelas de primaria y párvulos de barrios de trabajadores, el Centro de Asesoramiento para la Enseñanza en Ámsterdam y el Instituto de Investigación para la Psicología Aplicada. El IPA ofrece soluciones orientadas a cambios sociales y escolares. Especialmente se tratan los aspectos pedagógicos, dejando al margen las políticas a nivel urbano y nacional. Se desarrollan los medios, procedimientos y estructuras, utilizando las normas de investigación activa, con el fin de disminuir los problemas educativos de los hijos de los trabajadores.

The exclusionary policies of 'us and them' in the IPA and psychoanalytic institutes

This article will explore the issues of otherness in the IPA and also consider the local institute level using the example of the British Psychoanalytic Society. According to the IPA it is 'The world's primary psychoanalytic accrediting and regulatory body, with 10,500 members in over forty-five countries. The IPA works in partnership with its Component Organizations to train, support and network psychoanalysts, developing clinical, educational and research programmes'. It is well-known that the history of psychoanalysis is replete with organizational schisms and primary issues of 'inclusion-exclusion'. Who is a real psychoanalyst? "That are the necessary acceptable professional 'standards'? 'While standards' should be derived from knowledge, they are often derived from power and are often really a mask for power-plays. The others' have included those from both outside and within the psychoanalytic movement. Outsiders include medicine and the universities, psychotherapists, other psychoanalysts and other disciplines. Deviationists ,.vithin the IPA include other schools vvithin the'broad church' of psychoanalysis or even just those who don't fit with the proclivities of those in power sometimes rationalized into issues of standards

IPA: Integrated predictive gene signature from gene expression based breast cancer patient samples

Background: Novel predictive markers are needed to accurately diagnose the breast cancer patients so they do not need to undergo any unnecessary aggressive therapies. Various gene expression studies based predictive gene signatureshave generated in the recent past to predict the binary estrogen-receptor subclass or to predict the therapy response subclass. However, the existing algorithms comes with many limitations, including low predictive performances over multiple cohorts of patients and non-significant or limited biological roles associated with thepredictive gene signatures. Therefore, the aim of this study is to develop novel predictive markers with improved performances.Methods: We propose a novel prediction algorithm called IPA to construct a predictive gene signature for performing multiple prediction tasks of predicting estrogen-receptor based binary subclass and predicting chemotherapy response (neoadjuvantly) based binary subclass. The constructed gene signature with considering multiple classification techniques was used to evaluate the algorithm performance on multiple cohorts of breast cancer patients.Results: The evaluation on multiple validation cohorts demonstrated that proposed algorithm achieved stable and high performance to perform prediction tasks, with consideration given to any classification techniques. We show that the predictive gene signature of our proposed algorithm reflects the mechanisms underlying the estrogen-receptors or response to therapy with significant greater biological interpretations, compared with the other existing algorithm.

Tabla g[ene]ral sobre tots los 13 libres, autor fray Fr[ancis]co Eximenez, natural de Gerona del Princ[ipa]do de Cataluña, religioso fran[cisca]no [Manuscrito]

Tít. tomado de principio del texto

The secreted Ipa complex of Shigella flexneri promotes entry into mammalian cells.

The bacterial pathogen Shigella flexneri causes bacillary dysentery in humans by invading coloncytes. Upon contact with epithelial cells, S. flexneri elicits localized plasma membrane projections sustained by long actin filaments which engulf the microorganism. The products necessary for Shigella entry include three secretory proteins: IpaB, IpaC, and IpaD. Extracellular IpaB and IpaC associate in a soluble complex, the Ipa complex. We have immunopurified this Ipa complex on latex beads and found that they were efficiently internalized into HeLa cells. Like S. flexneri entry, uptake of the beads bearing the Ipa complex was associated with membrane projections and polymerization of actin at the site of cell-bead interaction and was dependent on small Rho GTPases. These results indicate that a secreted factor can promote S. flexneri entry into epithelial cells.

Disulfide oxidoreductase activity of Shigella flexneri is required for release of Ipa proteins and invasion of epithelial cells.

Secretion of IpaB, IpaC, and IpaD proteins of Shigella flexneri, essential for the invasion of epithelial cells, requires a number of proteins encoded by the spa and mxi loci on the large plasmid. Introduction of dsbA::Tn5 into S.flexneri from Escherichia coli K-12 reduced invasiveness, which resulted from a decrease in the capacity to release IpaB, IpaC, and IpaD proteins into the external medium. Examination of the surface-presented Ipa proteins of the dsbA mutant, however, revealed Ipa proteins at levels similar to those on wild-type cells. Since the defective phenotype was similar to that of the spa32 mutant of S. flexneri and the Spa32 sequence possessed two Cys residues, the effect of dsbA mutation of the folding structure of Spa32 under reducing conditions and on the surface expression of Spa32 was investigated. The results indicated that Spa32 was a disulfide-containing protein whose correctly folded structure was required for its presentation on the outer membrane. Indeed, replacing either one of the two Cys residues in Spa32 with Ser by site-directed mutagenesis reduced its capacity to release Ipa proteins into the external medium and led to the accumulation of Spa32 protein in the periplasm. These results indicated that the DsbA protein performs an essential function during the invasion of mammalian cells, by facilitating transport of the Spa32 protein across the outer membrane.