908 resultados para Horn, John, 1738-1805.


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Manuscript volume. The first thirty-nine pages include diary entries from Page's years as an undergraduate student at Harvard College. Dated July 1757 through March 1761, entries includes short notes about daily activities. Topics covered include expenses, academics, clothing, and travel to and from Cambridge. Twenty-two pages covering 1764 through 1781 contain brief listings of items, generally foodstuffs, received from male and female Danville parishioners identified by name in Danville. The final twenty-six pages contain notes listing area deaths, as well as his own thoughts on topics such as "of light" and "jealousy." The concluding pages include rules "Concerning Grammar."

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Weeks (of Greenland, N.H.) was accused of concealing and embezzling items from his late son's estate. Document is signed: William Parker reg.

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Under the provisions of the will of John Nicholas Brown, the collection was transferred in 1901 to Brown university.

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There is considerable evidence from animal studies that gonadal steroid hormones modulate neuronal activity and affect behavior. To study this in humans directly, we used H215O positron-emission tomography to measure regional cerebral blood flow (rCBF) in young women during three pharmacologically controlled hormonal conditions spanning 4–5 months: ovarian suppression induced by the gonadotropin-releasing hormone agonist leuprolide acetate (Lupron), Lupron plus estradiol replacement, and Lupron plus progesterone replacement. Estradiol and progesterone were administered in a double-blind cross-over design. On each occasion positron-emission tomography scans were performed during (i) the Wisconsin Card Sorting Test, a neuropsychological test that physiologically activates prefrontal cortex (PFC) and an associated cortical network including inferior parietal lobule and posterior inferolateral temporal gyrus, and (ii) a no-delay matching-to-sample sensorimotor control task. During treatment with Lupron alone (i.e., with virtual absence of gonadal steroid hormones), there was marked attenuation of the typical Wisconsin Card Sorting Test activation pattern even though task performance did not change. Most strikingly, there was no rCBF increase in PFC. When either progesterone or estrogen was added to the Lupron regimen, there was normalization of the rCBF activation pattern with augmentation of the parietal and temporal foci and return of the dorsolateral PFC activation. These data directly demonstrate that the hormonal milieu modulates cognition-related neural activity in humans.

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Nicotine influences cognition and behavior, but the mechanisms by which these effects occur are unclear. By using positron emission tomography, we measured cognitive activation (increases in relative regional cerebral blood flow) during a working memory task [2-back task (2BT)] in 11 abstinent smokers and 11 ex-smokers. Assays were performed both after administration of placebo gum and 4-mg nicotine gum. Performance on the 2BT did not differ between groups in either condition, and the pattern of brain activation by the 2BT was consistent with reports in the literature. However, in the placebo condition, activation in ex-smokers predominated in the left hemisphere, whereas in smokers, it occurred in the right hemisphere. When nicotine was administered, activation was reduced in smokers but enhanced in ex-smokers. The lateralization of activation as a function of nicotine dependence suggests that chronic exposure to nicotine or withdrawal from nicotine affects cognitive strategies used to perform the memory task. Furthermore, the lack of enhancement of activation after nicotine administration in smokers likely reflects tolerance.

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First edition in 2 volumes, New York, 1841.

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Contiene los textos de la época atribuidos a Geber, otros anónimos (Minera philosophorum, Liber de principiis naturalibus), otros de Giovanni Bracesco, Francesco Maria Santinelli (con el pseudónimo Marc'Antonio Crassellame), John Belye, Georg Horn, John Dastin, etc