993 resultados para Hill, William (1896-1958)
Resumo:
Référence bibliographique : Rol, 60583
Resumo:
There is evidence across several species for genetic control of phenotypic variation of complex traits1, 2, 3, 4, such that the variance among phenotypes is genotype dependent. Understanding genetic control of variability is important in evolutionary biology, agricultural selection programmes and human medicine, yet for complex traits, no individual genetic variants associated with variance, as opposed to the mean, have been identified. Here we perform a meta-analysis of genome-wide association studies of phenotypic variation using ~170,000 samples on height and body mass index (BMI) in human populations. We report evidence that the single nucleotide polymorphism (SNP) rs7202116 at the FTO gene locus, which is known to be associated with obesity (as measured by mean BMI for each rs7202116 genotype)5, 6, 7, is also associated with phenotypic variability. We show that the results are not due to scale effects or other artefacts, and find no other experiment-wise significant evidence for effects on variability, either at loci other than FTO for BMI or at any locus for height. The difference in variance for BMI among individuals with opposite homozygous genotypes at the FTO locus is approximately 7%, corresponding to a difference of ~0.5 kilograms in the standard deviation of weight. Our results indicate that genetic variants can be discovered that are associated with variability, and that between-person variability in obesity can partly be explained by the genotype at the FTO locus. The results are consistent with reported FTO by environment interactions for BMI8, possibly mediated by DNA methylation9, 10. Our BMI results for other SNPs and our height results for all SNPs suggest that most genetic variants, including those that influence mean height or mean BMI, are not associated with phenotypic variance, or that their effects on variability are too small to detect even with samples sizes greater than 100,000.
Resumo:
Childhood and education in Grodno and Lemberg; poor family background; active as soccer player; acting school of Max Reinhardt in Berlin; engagements in Munich, Zurich and Frankfurt; visit to Poland and short engagement with Yiddish theater troupe; description of theater in Weimar Germany; activities in "Juedischer Kulturbund" after 1933; main role in Kulturbund performance of "Nathan the Wise".
Resumo:
O presente trabalho se propõe a investigar, por meio de uma reconstrução sócio-histórica, a posição ímpar de Cornélio Penna e sua obra-prima, A menina morta, no cenário da literatura brasileira. O potencial de diferença deste romance será verificado a partir da abordagem de elementos biográficos, que nos oferecerão valiosas pistas para a compreensão de autor e obra; da observação da configuração original alcançada pelo escritor para, ficcionalmente, refletir a sociedade patriarcal-escravocrata e, ainda, do estudo de sua recepção na década de 1950, o qual nos oferecerá a compreensão do horizonte de expectativas de seus primeiros intérpretes, assim mostrando a dificuldade experimentada por esses críticos em estabelecerem um lugar para o romance corneliano no sistema literário brasileiro
Resumo:
Pós-graduação em Letras - IBILCE
Cabezas : siluetas de políticos, literatos, diplomáticos y otras liendres de la fauna pintoresca /
Resumo:
"... art iculos publicados en 'El diario' con el pseudónimo de 'Nolo Beas', ..."--Nota de los editores.
Resumo:
On cover: Scarsdale recreation survey 1945.
Resumo:
Includes bibliographies.
Resumo:
Previous editions published under title: The measurement of adult intelligence.
Resumo:
Mode of access: Internet.
Resumo:
Mode of access: Internet.
Resumo:
"Department of Army Project no. 5B99-01-004, Ordnance R and D Project no. TB2-0001. Office of Ordnance Research Project no. 1348 Contract no. DA-19-020-ORD-3520."
Resumo:
"Department of Army Project no. 5B99-01-004, Ordnance R and D Project no. TB2-0001, Office of Ordnance Research Project no. 1348, Contract no. DA-19-020-ORD-3250."