Speculum aureum fratris Henrici Herp de preceptis diuine legis.

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The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response.

Notch signalling has an important role in skin homeostasis, promoting keratinocyte differentiation and suppressing tumorigenesis. Here we show that this pathway also has an essential anti-apoptotic function in the keratinocyte UVB response. Notch1 expression and activity are significantly induced, in a p53-dependent manner, by UVB exposure of primary keratinocytes as well as intact epidermis of both mouse and human origin. The apoptotic response to UVB is increased by deletion of the Notch1 gene or down-modulation of Notch signalling by pharmacological inhibition or genetic suppression of 'canonical' Notch/CSL/MAML1-dependent transcription. Conversely, Notch activation protects keratinocytes against apoptosis through a mechanism that is not linked to Notch-induced cell cycle withdrawal or NF-kappaB activation. Rather, transcription of FoxO3a, a key pro-apoptotic gene, is under direct negative control of Notch/HERP transcription in keratinocytes, and upregulation of this gene accounts for the increased susceptibility to UVB of cells with suppressed Notch signalling. Thus, the canonical Notch/HERP pathway functions as a protective anti-apoptotic mechanism in keratinocytes through negative control of FoxO3a expression.

Development of CHH family recombinant hormones and RNAi for induced maturation of Penaeus monodon

About 80 years ago, the neurosecretory eyestalk structures and their role in endocrine regulation was recognized in crustaceans. After the recognition it took half a century to identify the first peptide hormone. Till date a large number of homologous peptides of crustacean hyperglycaemic hormone and moult-inhibiting hormone have been identified, consequently they are called the CHH family hormones. This family comprises of highly multifunctional peptides which according to sequences and precursor structures can be divided into two subfamilies, type-I (CHH/ITP) and II (MIH, MOIH, VIH/GIH) (Webster et al., 2012). The XO-SG complex has been the major site of the two subfamilies. The advent of molecular techniques resulted in the characterization of different precursors of CHH, MIH and GIH; these hormones consist of a signal peptide, but only the preprohormone of CHHs contain a precursor- related peptide (CPRP) located between the signal and the mature hormone (Weidemann et al., 1989; Klein et al., 1993b; De Kleijn and Van Herp, 1995). The essentialities of the gene structure comply with the functions of the CHH family hormones. The CHH family hormone functions are inhibitory as well as stimulatory in the process of reproduction and maturation

Evaluation of helminths associated with 14 amphibian species from a Neotropical island near the southeast coast of Brazil

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

[Espejo de perfecio[n] /

Apercebimiento para que sepan los que leyeren este libro que su doctrina es comun y muy necesaria para todos, f.ij-vij. - Siguese el tractado llamado Espejo de perfecio[n] ... Libro primero de las mortificaciones, f. vij-xxxviii ; Libro segundo de la vida espiritual, f. xl-lxx. - Memorial de la vida de n[uest[ro redemptor Iesu Christo. Ordenado y repartido en siete conte[n]placiones para todos los días de la semana. Compilado por un predicador de la orden ... sant Francisco, f. lxxij-cxiiij. - Espistola de Sant Bernardo de la perfecion de la vida espiritual, f. cx-cxvij.

R.P. Iulii Fatii Societatis Iesu, Liber de mortificatione nostrarum passionum, prauorumque affectuum : nunc primum ex italica lingua in latinam translats : cui nouiter adiunctum est D. Henrici Harphii Directorium aureum contemplatiuorum complectens Mortificationes duodecim

"Directorium aureum contemplatiuorum complectens Mortificationes duodecim" con portada desde la p.201.