Appendix to the Canada papers : relating principally to the Convention Army after its arrival in the neighbourhood of Boston, in the years 1777 and 1778.

Mostly correspondence between Generals Burgoyne and Heath, letters dated 8 November 1777-13 April 1778.

History of the battle of Breed's Hill,

Mode of access: Internet.

Memoir of William Randall Saxton, of Lebanon, Conn. With the funeral sermon.

Mode of access: Internet.

Memorial addresses on the life and character of William D. Kelley, a representative from Pennsylvania, delivered in the House of Representatives and in the Senate / Fifty-first Congress, first session.

"March 15, 1890"--Cover.

The internal taxes - shall they be perpetuated or abolished? Speech of Hon. William D. Kelley, of Pennsylvania, in the House of Representatives, May 1, 1872.

Caption title.

Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8α+ dendritic cells

Although CD8+ T cells do not contribute to protection against the blood stage of Plasmodium infection, there is mounting evidence that they are principal mediators of murine experimental cerebral malaria (ECM). At present, there is no direct evidence that the CD8+ T cells mediating ECM are parasite-specific or, for that matter, whether parasite-specific CD8+ T cells are generated in response to blood-stage infection. To resolve this and to define the cellular requirements for such priming, we generated transgenic P. berghei parasites expressing model T cell epitopes. This approach was necessary as MHC class I-restricted antigens to blood-stage infection have not been defined. Here, we show that blood-stage infection leads to parasite-specific CD8+ and CD4+ T cell responses. Furthermore, we show that P. berghei-expressed antigens are cross-presented by the CD8α+ subset of dendritic cells (DC), and that this induces pathogen-specific cytotoxic T lymphocytes (CTL) capable of lysing cells presenting antigens expressed by blood-stage parasites. Finally, using three different experimental approaches, we provide evidence that CTL specific for parasite-expressed antigens contribute to ECM.

Systemic activation of dendritic cells by toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity

The mechanisms responsible for the immunosuppression associated with sepsis or some chronic blood infections remain poorly understood. Here we show that infection with a malaria parasite (Plasmodium berghei) or simple systemic exposure to bacterial or viral Toll-like receptor ligands inhibited cross-priming. Reduced cross-priming was a consequence of downregulation of cross-presentation by activated dendritic cells due to systemic activation that did not otherwise globally inhibit T cell proliferation. Although activated dendritic cells retained their capacity to present viral antigens via the endogenous major histocompatibility complex class I processing pathway, antiviral responses were greatly impaired in mice exposed to Toll-like receptor ligands. This is consistent with a key function for cross-presentation in antiviral immunity and helps explain the immunosuppressive effects of systemic infection. Moreover, inhibition of cross-presentation was overcome by injection of dendritic cells bearing antigen, which provides a new strategy for generating immunity during immunosuppressive blood infections.

A representação da natureza no romance francês do século XIX

Busca-se determinar as características da representação da natureza no romance francês do século XIX, analisando-se Paul et Virginie de Bernardin de Saint-Pierre, Les travailleurs de la mer de Victor Hugo e L’Ève future de Villiers de l’Isle-Adam, por meio da teoria sócio-crítica e do embate com o texto. Na primeira parte, faz-se um retrospecto da representação nas artes e na literatura, destacando-se as concepções de Aristóteles e as do Romantismo. Apresenta-se também um panorama das concepções da natureza no tempo e no espaço e reflete-se sobre as relações do homem com o mundo natural, bem como sobre as teorias a elas referentes no âmbito da história, da pintura e da literatura. Na segunda parte, analisam-se os três romances escolhidos, buscando-se neles os modos e os sentidos da representação literária da natureza. Conclui-se pela existência, nas três obras estudadas, de uma atitude ambígua do homem diante da natureza, que havia sido anteriormente detectada na história. Embora diferenciadas entre si, sob alguns aspectos, as representações da natureza no corpus estudado demonstram o registro, no universo literário, de marcas do contexto histórico, político e social em que os três romances foram escritos, publicados e usufruidos.

Ontogeny of T cell tolerance to peripherally expressed antigens

Transgenic expression of the influenza virus hemagglutinin (HA) in the pancreatic islet β cells of InsHA mice leads to peripheral tolerance of HA-specific T cells. To examine the onset of tolerance, InsHA mice were immunized with influenza virus A/PR/8 at different ages, and the presence of nontolerant T cells was determined by the induction of autoimmune diabetes. The data revealed a neonatal period wherein T cells were not tolerant and influenza virus infection led to HA-specific β cell destruction and autoimmune diabetes. The ability to induce autoimmunity gradually waned, such that adult mice were profoundly tolerant to viral HA and were protected from diabetes. Because cross-presentation of islet antigens by professional antigen-presenting cells had been reported to induce peripheral tolerance, the temporal relationship between tolerance induction and activation of HA-specific T cells in the lymph nodes draining the pancreas was examined. In tolerant adult mice, but not in 1-week-old neonates, activation and proliferation of HA-specific CD8+ T cells occurred in the pancreatic lymph nodes. Thus, lack of tolerance in the perinatal period correlated with lack of activation of antigen-specific CD8+ T cells. This work provides evidence for the developmental regulation of peripheral tolerance induction.

CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose

There are two major mechanisms reported to prevent the autoreactivity of islet-specific CD8+ T cells: ignorance and tolerance. When ignorance is operative, naïve autoreactive CD8+ T cells ignore islet antigens and recirculate without causing damage, unless activated by an external stimulus. In the case of tolerance, CD8+ T cells are deleted. Which factor(s) contributes to each particular outcome was previously unknown. Here, we demonstrate that the concentration of self antigen determines which mechanism operates. When ovalbumin (OVA) was expressed at a relatively low concentration in the pancreatic islets of transgenic mice, there was no detectable cross-presentation, and the CD8+ T cell compartment remained ignorant of OVA. In mice expressing higher doses of OVA, cross-presentation was detectable and led to peripheral deletion of OVA-specific CD8+ T cells. When cross-presentation was prevented by reconstituting the bone marrow compartment with cells incapable of presenting OVA, deletional tolerance was converted to ignorance. Thus, the immune system uses two strategies to avoid CD8+ T cell-mediated autoimmunity: for high dose antigens, it deletes autoreactive T cells, whereas for lower dose antigens, it relies on ignorance.

Notebook of James Lovell, 1757-1760

Marbled paper-covered handwritten notebook of James Lovell. The volume contains three texts written in Latin, “Praecellentissime Domine,” dated 1757, an untitled text beginning, “Cogitanti mihi et superiorum revolti…” dated 1759, and Lovell’s funeral oration for Tutor Henry Flynt titled “Oratio funebris” dated 1760. The Latin texts are followed by blank pages and the volume ends with an untitled English text about orators that begins, “Ridiculous certainly is that Practice of some...” The last page of the text includes the marginal notes: “John Winthrop Esqr. Hollisian Professor” and, “For T.H. of Carolina.” There are verses attributed to the London Magazine written on the inside front cover.

Kaye's and Malleson's History of the Indian mutiny of 1857-8 /

Vols. 3-6, by Malleson, first appeared under title: History of the Indian mutiny, 1857-1858, commencing from the close of the second volume of Sir John Kaye's History of the Sepoy War.

Harmonies de la nature /

Mode of access: Internet.

Etudes de la nature /

Mode of access: Internet.