Preoperative hyperfractionated accelerated radiotherapy (HART) and concomitant CPT-11 in locally advanced rectal carcinoma: a phase I study.

PURPOSE: Patients with locally advanced rectal carcinoma are at risk for both local recurrence and distant metastases. We demonstrated the efficacy of preoperative hyperfractionated accelerated radiotherapy (HART). In this Phase I trial, we aimed at introducing chemotherapy early in the treatment course with both intrinsic antitumor activity and a radiosensitizer effect. METHODS AND MATERIALS: Twenty-eight patients (19 males; median age 63, range 28-75) with advanced rectal carcinoma (cT3: 24; cT4: 4; cN+: 12; M1: 5) were enrolled, including 8 patients treated at the maximally tolerated dose. Escalating doses of CPT-11 (30-105 mg/m(2)/week) were given on Days 1, 8, and 15, and concomitant HART (41.6 Gy, 1.6 Gy bid x 13 days) started on Day 8. Surgery was to be performed within 1 week after the end of radiochemotherapy. RESULTS: Twenty-six patients completed all preoperative radiochemotherapy as scheduled; all patients underwent surgery. Dose-limiting toxicity was diarrhea Grade 3 occurring at dose level 6 (105 mg/m(2)). Hematotoxicity was mild, with only 1 patient experiencing Grade 3 neutropenia. Postoperative complications (30 days) occurred in 7 patients, with an anastomotic leak rate of 22%. CONCLUSIONS: The recommended Phase II dose of CPT-11 in this setting is 90 mg/m(2)/week. Further Phase II exploration at this dose is warranted.

[Mike] Honeyman [portrait du boxeur] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 61696

Dr. Mike Dickman

Professor Dickman examining the water.

Wrestling Card - Mike Mazurki

The wrestler's name is Mike Mazurki and the number stamped on the reverse is 459.

Wrestling Card - Mike Sharpe

The wrestler's name is Mike Sharpe and the number on the reverse is 142, the second card is stamped 704, the third is stamped 599, and the fourth is stamped 615. He was born in Hamilton, Ontario and was part of one of the most successful tag teams in history (with brother Ben Sharpe). Mike's son, Mike Jr. also had a successful career as a pro wrestler under the name Iron Mike Sharpe through the 1970s and 1980s. The honours include the Canadian Wrestling Hall of Fame.

Indenture - Land sold by Hart Smith of Lincoln County to James Fields of Newark in Oxford County

Indenture regarding land sold by Hart Smith of Lincoln County to James Fields of Newark in Oxford County, First Concession, Lot no. 3. October 11, 1797.

Indenture between Joseph Hamilton to Jonathan Hart and Thomas Hart

Indenture between Joseph Hamilton of late of Queenston by his attorney Samuel Street to Jonathan Hart and Thomas Hart of Queenston for the sale of land in the township of Saltfleet, Lot no. 8 in the 6th Concession. There are holes in the document and the back is stained, but this does not affect the text, November 9, 1829.

Indenture between Joseph Hamilton and Joseph Hart

Indenture of sale between Joseph Hamilton of London and Joseph Hart of Montgomery County. This is regarding Lot no. 25 in the 5th concession in the Township of Norwich in the County of Oxford, May 11, 1833.

Letter from the office of Hart, Ball and Hart of Buffalo, New York to William R. Allen of St. Catharines, Ont.

Letter (2 pages, handwritten) from the office of Hart, Ball and Hart of Buffalo, New York to William R. Allen of St. Catharines, Ont. proposing work to be done regarding the hot water heating of the building. The owner of the building is expected to pay the railway fare of the men and to pay their board while they are in St. Catharines, July 8, 1876.