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Last Will and Testament - Deborah Clow

Probate of the Last Will and Testament of Deborah Clow of the Township of Stamford. Richard Woodruff is the executor. Deborah bequeathed 1/2 of 63 acres of land in Stamford to her friend William Woodruff of St. Davids. The other 1/2 of the land belonged to her sister Levina Wilkinson - instrument no. 3638, Setepmber 4.

Indenture of quit claim between John and Deborah Ann McNeilly of the Town of Niagara and Joseph Augustus Woodruff of the Town of Niagara

Indenture of quit claim between John and Deborah Ann McNeilly of the Town of Niagara and Joseph Augustus Woodruff of the Town of Niagara regarding 4 acres on the west side of King Street in Niagara, Dec. 4, 1853.

Deregulated expression of Kruppel-like factors in acute myeloid leukemia

The known participation of Kruppel-like transcription factors (KLF) in cellular differentiation prompted us to investigate their expression in acute myeloid leukemia (AML) blast cells that are typically blocked in their differentiation. We determined the expression patterns of KLFs with a putative role in myeloid differentiation in a large cohort of primary AML patient samples, CD34+ progenitor cells and granulocytes from healthy donors. We found that KLF2, KLF3, KLF5 and KLF6 are significantly lower expressed in AML blast and CD34+ progenitor cells as compared to normal granulocytes. Moreover, we found markedly increased KLF levels in acute promyelocytic leukemia patients who received oral ATRA. Accordingly, we observed a strong induction of KLF5/6 upon ATRA-treatment in NB4 and HT93 APL but not in ATRA-resistant NB4-R cells. Lastly, knocking down KLF5 or KLF6 in NB4 cells significantly attenuated neutrophil differentiation. In conclusion, we found a significant repression of KLF transcription factors in primary AML samples as compared to mature neutrophils and further show that KLF5 and KLF6 are functionally involved in neutrophil differentiation of APL cells.