991 resultados para HEN-SHI-KO
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Mode of access: Internet.
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Background/Aims: Hepatocellular carcinoma (HCC) is a well recognized complication of advanced NASH (non-alcoholic steatohepatitis). We sought to produce a rat model of NASH, cirrhosis and HCC. Methods: Adult Sprague-Dawley rats, weighing 250-300 g, were fed a choline-deficient, high trans-fat diet and exposed to DEN in drinking water. After 16 weeks, the animals underwent liver ultrasound (US), sacrifice and assessment by microscopy, immunohistochemistry and transmission electron microscopy (TEM). Results: US revealed steatosis and focal lesions in 6 of 7. All had steatohepatitis defined as inflammation, advanced fibrosis and ballooning with Mallory-Denk bodies (MDB) with frank cirrhosis in 6. Areas of more severe injury were associated with anti-CK19 positive ductular reaction. HCC, present in all, were macro-trabecullar or solid with polyhedral cells with foci of steatosis and ballooned cells. CK19 was positive in single or solid nests of oval cells and in neoplastic hepatocytes. TEM showed ballooning with small droplet fat, dilated endoplasmic reticulum and MDB in non-neoplastic hepatocytes and small droplet steatosis in some cancer cells. Conclusions: This model replicated many features of NASH including steatohepatitis with ballooning, fibrosis, cirrhosis and hepatocellular carcinoma. Oval cell proliferation was evident and the presence anti-CK 19 positivity in the cancer suggests oval cell origin of the malignancy. (C) 2008 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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On double leaves, oriental style.
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Mode of access: Internet.
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dai 1-satsu. Meiji kokusei hatten hen -- dai 2-satsu. Meiji kenpō seitei hen -- dai 3-satsu. Meiji Taishō ishin hen -- dai 4-satsu. Edo bakufu suibō hen -- dai 5-satsu. Edo bakufu kisei hen, Edo bakufu chūsei hen -- dai 6-satsu. Edo bakufu shosei hen, Oda Toyotomi-shi hen -- dai 7-satsu. Muromachi bakufu ransei hen, Nanbokuchō oyobi Muromachi jisei hen -- dai 8-satsu. Kamakura bakufu hen, Insei oyobi Genpei seisui hen -- dai 9-satsu. Heianchō seisei oyobi Tōshi senken hen, Ritsuryō shūsen oyobi Narachō hen -- dai 10-satsu. Jindai oyobi jōko hen -- dai [11]-satsu. Sakuin.
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This layer is a georeferenced raster image of the historic paper map entitled: Teikoku Kyōto shigai meisho shinzu, Kataoka Kenzō hen. It was published by Fūgetsu Shōzaemon in Meiji 27-nen [1894]. Scale [ca. 1:17,000]. Covers Kyōto-shi, Japan. Map in Japanese.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Tokyo Universal Transverse Mercator (UTM) Zone 53N projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, streets, railroads, mountains, built-up areas and selected buildings, and more. Relief shown pictorially. Includes views of places of interest.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.
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Includes index.
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Mode of access: Internet.
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Non-Latin script record
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Hanken menkyo Meiji 14 [1881] -- colophon.
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Mode of access: Internet.
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Hyōshi no shomei: Christian names.
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Title from cover.
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Description based on: Dai 4-gō, published in Jan. 1923; title from cover.
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Blockprint.
