Impact Of Severe Haemophilia A On Patients' Health Status: Results From The Guardian(™) 1 Clinical Trial Of Turoctocog Alfa (novoeight(®) ).

Haemophilia and its treatment interfere with patients' life and may affect adherence to treatment. This study explored the impact of severe haemophilia A on patients' health status, especially in young adults (YA), using data from guardian(™) 1, a multinational, open-label, non-controlled phase 3 trial investigating safety and efficacy of turoctocog alfa (NovoEight(®) ) in previously treated patients aged 12 years and older with severe haemophilia A (FVIII ≤ 1%). Health status was assessed using the EuroQoL-5 dimensions (EQ-5D-3L), covering 5 dimensions of health (mobility, self-care, usual activities, pain/discomfort and anxiety/depression), and a visual analogue scale (VAS) measuring self-rated overall health status. EQ-5D was administered pretreatment (screening/baseline) and posttreatment (end-of-trial). Baseline responses to the EQ-5D dimensions and VAS were described overall and by age and compared to reference values from UK general population. Guardian(™) 1 included 150 patients (16 adolescents, 83 YA aged 16-29 and 51 adults aged 30+). All five dimensions of patients' health status were impacted at baseline. The percentage of haemophilia patients reporting problems was consistently significantly greater than age-matched general population reference values. Likewise, for all age groups mean baseline EQ-5D VAS score was significantly lower for haemophilia patients (YA: 78.0) than for the general population (YA aged 18-29: 87.3). The health status of patients with severe haemophilia A entering guardian(™) 1 was markedly poorer than that of the general population, particularly regarding mobility and pain. YA patients reported better health status than older patients, but considerably lower than that of the general YA population.

O casamento real de William e Kate : a cobertura jornalística nos jornais The Daily Mail, The Guardian e The Sun

Dissertação apresentada à Escola Superior de Comunicação Social como parte dos requisitos para obtenção de grau de mestre em Jornalismo.

Gluco Guardian

Desenvolupament d'un software integral de gestió i control de les glucèmies dels pacients hospitalitzats.

Apelación frívola que de la sentencia definitiva pronunciada por N.Rmo. P. Rafael de Lugagnano el día 29 de mayo de 1748 en su convento de Aracoeli de Roma, a favor de el P. Guardian de el Convento de San Antonio, de religiosos Franciscanos Fescalzos de la Ciudad de Querétaro, en la Nueva España, Interpuso el padre guardián de la Santa Cruz, de Misioneros Apostolicos de la misma ciudad. Declarada nula por N.Rmo. P. Fr. Pedro Juan de Molina...

UANL

High density lipoprotein: guardian of the vascular system?

The role of low-density lipoprotein in the development of coronary heart disease (CHD) is well recognised. There is also growing evidence that high-density lipoprotein cholesterol (HDL-C) is a powerful inverse predictor for premature CHD and that maintaining a high HDL-C level may guard against atherosclerosis. Patients with low HDL-C levels often also have central obesity, insulin resistance and other features of the metabolic syndrome. This syndrome is both increasingly common and strongly implicated in the growing worldwide epidemic of type 2 diabetes. HDL-C may be increased by lifestyle changes, e.g. weight loss, physical activity and smoking cessation. Pharmacological agents such as fibrates, niacin and statins have also been shown significantly to elevate HDL-C. Although current guidelines are beginning to recognise the protective role of HDL-C level in preventing coronary events, HDL-C should be adopted soon as a target for intervention in its own right.

O Brasil que não é bem assim: representações do Brasil na cobertura da Copa do Mundo 2014 pelo jornal The Guardian

Pós-graduação em Comunicação - FAAC

O Brasil que não é bem assim: representações do Brasil na cobertura da Copa do Mundo 2014 pelo jornal The Guardian

Pós-graduação em Comunicação - FAAC

A survey on intestinal parasites of livestock guardian dogs and herding dogs in Switzerland

The present study describes the occurrence of intestinal parasite infections in livestock guardian dogs and herding dogs. A total of 71 guardian dogs (more than half of the total number of guardian dogs in Switzerland) and 21 herding dogs were coprologically examined, using a combined sedimentation-flotation method. In 21 (23 %) of the dogs intestinal parasites were detected, and 8 (8.7 %) of these dogs shed either sporocysts of Sarcocystis sp. (n = 6) or taeniid eggs (n = 2). The evaluation of questionnaires providing data on age, origin and deworming schemes of the dogs completed the study.

Certificate to John Walton, guardian to Nathaniel Jarvis, 1804 November 22

This brief handwritten document certifies that the guardianship of Richard Nichols of Reading, Massachusetts, was granted to yeoman Thomas Hartshorn of Reading according to the records of the Probate Court in Framingham, Massachusetts. The document is attested by James Winthrop in his capacity as register of probate for Middlesex County.

Certificate to Thomas Hartsorn, guardian of Richard Nichols, 1812 June 18

This brief handwritten document certifies that the guardianship of Nathaniel Jarvis of Cambridge, Massachusetts, was granted to John Walton of Cambridge according to the records of the Probate Office in Cambridge. The document is attested by James Winthrop in his capacity as register of probate for Middlesex County.