General function of the gall bladder from the evolutionary standpoint, by Frank W. Gorham and Andrew Conway Ivy.

v.22:no.3(1938)

Doença de Gorham da escápula e clavícula: relato de caso e evolução de dois anos de uma afecção rara

A doença de Gorham é uma rara desordem osteolítica, de etiologia controversa, que pode afetar qualquer osso. O substrato histopatológico é a substituição óssea por uma formação expansiva de natureza vascular agressiva, não neoplásica. Descrevemos os achados radiográficos, tomográficos e de ressonância magnética de um caso desta afecção acometendo a escápula esquerda e, dois anos depois, a clavícula ipsilateral.

Instrumentación inteligente y la tecnología del Fieldbus por Dolores Gabriela Palomares Gorham

Tesis (Maestría en Ciencias de la Ingeniería Eléctrica con Especialidad en Electrónica) U.A.N.L.

History of Gorham, Me.,

Genealogy: p. [383]-843.

Christian communion. A sermon delivered June 12, 1822, at the installation of Rev. Thaddeus Pomeroy, as pastor of the Congregational Church in Gorham, Me. /

Mode of access: Internet.

An address delivered at the funeral of John Gorham, M.D. : on the 31st day of March, 1829, by the appointment of the Boston Medical Association, and published at their request /By James Jackson, M.D.

Mode of access: Internet.

Substance of a speech delivered before the Judicial Committee of the Privy Council, on Monday the 17th and Tuesday the 18th of Dec., A.D. 1849 : upon an appeal in a cause of duplex querela, between the Rev. George Cornelius Gorham, ... and the Right Rev. Henry, Lord Bishop of Exeter, espondent ; with an introd. /

Mode of access: Internet.

De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot

Tetralogy of Fallot (TOF), the most common severe congenital heart malformation, occurs sporadically, without other anomaly, and from unknown cause in 70% of cases. Through a genome-wide survey of 114 subjects with TOF and their unaffected parents, we identified 11 de novo copy number variants (CNVs) that were absent or extremely rare (<0.1%) in 2,265 controls. We then examined a second, independent TOF cohort (n = 398) for additional CNVs at these loci. We identified CNVs at chromosome 1q21.1 in 1% (5/512, P = 0.0002, OR = 22.3) of nonsyndromic sporadic TOF cases. We also identified recurrent CNVs at 3p25.1, 7p21.3 and 22q11.2. CNVs in a single subject with TOF occurred at six loci, two that encode known (NOTCH1, JAG1) disease-associated genes. Our findings predict that at least 10% (4.5-15.5%, 95% confidence interval) of sporadic nonsyndromic TOF cases result from de novo CNVs and suggest that mutations within these loci might be etiologic in other cases of TOF.

Biologia Centrali-Americana :zoology, botany and archaeology /edited by Frederick Ducane Godman and Osbert Salvin.

Insecta. Coleoptera. v. 3. pt. 2. Malacodermata by the Rev. H.S. Gorham (1880-1886).

Biologia Centrali-Americana :zoology, botany and archaeology /edited by Frederick Ducane Godman and Osbert Salvin.

Insecta. Coleoptera. v. 7. Erotylidae, Endomychidae and Coccinellidae by H.S. Gorham (1887-1899).

Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres.

The mammalian Ku70 and Ku86 proteins form a heterodimer that binds to the ends of double-stranded DNA in vitro and is required for repair of radiation-induced strand breaks and V(D)J recombination [1,2]. Deletion of the Saccharomyces cerevisiae genes HDF1 and HDF2--encoding yKu70p and yKu80p, respectively--enhances radiation sensitivity in a rad52 background [3,4]. In addition to repair defects, the length of the TG-rich repeat on yeast telomere ends shortens dramatically [5,6]. We have shown previously that in yeast interphase nuclei, telomeres are clustered in a limited number of foci near the nuclear periphery [7], but the elements that mediate this localization remained unknown. We report here that deletion of the genes encoding yKu70p or its partner yKu80p altered the positioning of telomeric DNA in the yeast nucleus. These are the first mutants shown to affect the subnuclear localization of telomeres. Strains deficient for either yKu70p or yKu80p lost telomeric silencing, although they maintained repression at the silent mating-type loci. In addition, the telomere-associated silencing factors Sir3p and Sir4p and the TG-repeat-binding protein Rap1p lost their punctate pattern of staining and became dispersed throughout the nucleoplasm. Our results implicate the yeast Ku proteins directly in aspects of telomere organization, which in turn affects the repression of telomere-proximal genes.

Nicolaus de Gorran, Themata (1-95v), Distinctiones ad praedicandum vel Distinctiones theologicae (95v-207).

Abbaye Saint-Maur-des-Fossés ; cf. B. de Montfaucon, Bibliotheca bibliothecarum, II, 1739, p. 1141-1143 : "50. 1073. Nicolai de Gorham O. P. sermonum * Hiemata". Ex-libris : F. 1 : "Sti Germani a Pratis". Paris (Saint-Maur-des-Fossés ?).