A report of the trial of Pedro Gibert, Bernardo de Soto, Francisco Ruiz, Nicola Costa, Antonio Ferrer, manuel Boyga, Domingo de Guzman, Juan Antonio Portana, Manuel Castillo, Angel Garcia, Jose Velazquez, and Juan Montenegro alias Jose Basilio de Castro, before the United States Circuit court, on an indictment charging them with the commission of an act of piracy, on board the brig Mexican, of Salem ; containing a full statement of the testimony, and the arguments of the counsel on both sides, the charge of the court, pronounced by the Hon. Judge Story, and the verdict of the jury. With an appendix containing several documents never before published. by a congressional stenographer.

"Third edition."

Artificial activation of bovine and equine oocytes with cycloheximide, roscovitine, strontium, or 6-dimethylaminopurine in low or high calcium concentrations

Knowledge on parthenogenetic activation of oocytes is important to improve the efficiency of nuclear transfer (NT) and intracytoplasmic sperm injection (ICSI) because artificial activation of oocyte (AOA) is an essential step to achieve embryo production. Although different procedures for AOA have been established, the efficiency of in vitro production of embryos remains low, especially in equines and Bos taurus bovines. In an attempt to improve the techniques of NT and ICSI in bovine and equine species, we tested different combinations of drugs that had different mechanisms of action for the parthenogenetic activation of oocytes in these animals. The oocytes were collected, in vitro matured for 24 to 30 h and activated artificially, in the presence of low or high concentrations of calcium, with combinations of calcium ionophore (ionomycin) with cycloheximide, roscovitine, strontium, or 6-dimethylaminopurine (6-DMAP). For assessment of activation rates, oocytes were stained with Hoechst 33342 and observed under an inverted microscope. We showed that all combinations of drugs were equally efficient in activating bovine oocytes, with the best results obtained when high concentrations of calcium were adopted. For equine oocytes, high concentrations of calcium were not beneficial for the parthenogenetic activation and the combination of ionomycin with either 6-DMAP or roscovitine was effective in inducing artificial activation of oocytes. We believe that our preliminary findings provide some clues for the development of a better AOA protocol to be used with these species.

Hādhihi Risālah fī al-ijāzah / lil-Imām al-Ḥāfiẓ al-Awḥad al-Mutqin Abū al-Muẓaffar Manṣūr ibn Salīm al-Hamadānī al-Iskandarī al-Shāfiʻī : manuscript, 1865 or 6

Cream laid paper.

al- Murabbaʻ fī ḥukm al-ʻaqd ʻalá al-madhāhib al-arbaʻ : manuscript, [1735 or 6]

With: Hādhihi al-Fatāwá lil-ʻAllāmah al-Shaykh Muḥammad al-Khalīlī al-Maqdisī al-Shāfiʻī (ff. 4v-39r).

Kitāb Risālat al-murīd al-makhṣūṣ min rabbihi al-ḥamīd / lil-Sayyid al-ʻārif al-kabīr wa-al-quṭb al-shahīr ʻAbd Allāh ibn ʻAlawī al-Ḥaddād : manuscript, 1865 or 6

Written in one column, 9 lines per page, in black and red.

Sharḥ Ṣalāt Ibn Mashīsh : manuscript, 1865 or 6

Cream laid paper.

Hādhihi al-Fatāwá lil-ʻAllāmah al-Shaykh Muḥammad al-Khalīlī al-Maqdisī al-Shāfiʻī : manuscript, 1735 or 6

Dated 1148 [1735-6] (f. 39r).

25-hydroxycholesterol, 7β-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages

Recent studies have shown that Toll-like receptor (TLR)- signalling contributes significantly to the inflammatory events of atherosclerosis. As products of cholesterol oxidation (oxysterols) accumulate within atherosclerotic plaque and have been proposed to contribute to inflammatory signalling in the diseased artery, we investigated the potential of 7-ketocholesterol (7-KC), 7β-hydroxycholesterol (7β-HC) and 25-hydroxycholesterol (25-HC) to stimulate inflammatory signalling via the lipid-recognising TLRs 1, 2, 4 and 6. Each oxysterol stimulated secretion of the inflammatory chemokine interleukin-8 (IL-8), but not I?B degradation or tumour necrosis factor- release from monocytic THP-1 cells. Transfection of TLR-deficient HEK-293 cells with TLRs 1, 2, 4 or 6 did not increase sensitivity to the tested oxysterols. Moreover, blockade of TLR2 or TLR4 with specific inhibitors did not reduce 25-hydroxycholesterol (25-HC) induced IL-8 release from THP-1 cells. We conclude that although the oxysterols examined in this study may contribute to increased expression of certain inflammatory genes, this occurs by mechanisms independent of TLR signalling.

Hādhihi Safīnat al-mulk wa-nafīsat al-fulk [microform] /

Caption title.

Fische aus Caschmir /

Mode of access: Internet.

PEDro or Cochrane to Assess the Quality of Clinical Trials? A Meta-Epidemiological Study.

OBJECTIVE There is debate on how the methodological quality of clinical trials should be assessed. We compared trials of physical therapy (PT) judged to be of adequate quality based on summary scores from the Physiotherapy Evidence Database (PEDro) scale with trials judged to be of adequate quality by Cochrane Risk of Bias criteria. DESIGN Meta-epidemiological study within Cochrane Database of Systematic Reviews. METHODS Meta-analyses of PT trials were identified in the Cochrane Database of Systematic Reviews. For each trial PeDro and Cochrane assessments were extracted from the PeDro and Cochrane databases. Adequate quality was defined as adequate generation of random sequence, concealment of allocation, and blinding of outcome assessors (Cochrane criteria) or as trials with a PEDro summary score ≥5 or ≥6 points. We combined trials of adequate quality using random-effects meta-analysis. RESULTS Forty-one Cochrane reviews and 353 PT trials were included. All meta-analyses included trials with PEDro scores ≥5, 37 (90.2%) included trials with PEDro scores ≥6 and only 22 (53.7%) meta-analyses included trials of adequate quality according to the Cochrane criteria. Agreement between PeDro and Cochrane was poor for PeDro scores of ≥5 points (kappa = 0.12; 95% CI 0.07 to 0.16) and slight for ≥6 points (kappa 0.24; 95% CI 0.16-0.32). When combining effect sizes of trials deemed to be of adequate quality according to PEDro or Cochrane criteria, we found that a substantial difference in the combined effect size (≥0.15) was evident in 9 (22%) out of the 41 meta-analyses for PEDro cutoff ≥5 and 10 (24%) for cutoff ≥6. CONCLUSIONS The PeDro and Cochrane approaches lead to different sets of trials of adequate quality, and different combined treatment estimates from meta-analyses of these trials. A consistent approach to assessing RoB in trials of physical therapy should be adopted.

A report of the trial of Pedro Gibert ... [et al.], before the United States Circuit Court, on an indictment charging them with the commission of an act of piracy, on board the brig Mexican, of Salem : containing a full statement of the testimony, and the arguments of the counsel on both sides ... /

Trial of the captain and part of the crew of the Spanish schooner Panda.

Trial of the twelve Spanish pirates of the Schooner Panda, a Guinea slaver microform : consisting of Don Pedro Gibert, captain, Bernardo de Soto, mate ... : for robbery and piracy committed on board the Brig Mexican, 20th Sept. 1832.

At head of title: A full and accurate report--20 engravings.