Directly Elected Mayors and their Parties: The Cases of Genoa and Lausanne

While the literature on directly elected mayors has largely neglected the relationship between mayors and their parties, studies of party transformation have generally ignored how changes in local democratic rules and practices affect parties. This article addresses these questions using a qualitative case study of the relationship between mayors and the three faces of their parties (in local public office, local central office and on the ground) in Genoa and Lausanne. Based on interviews with the mayors, elected representatives and party members, it finds in the two cases that, as long as these mayors can count on high levels of popularity and are not nearing the end of their term, they are 'party detached'. When these factors do not apply and/or party institutionalization increases, the relationship with the party in local central office (although not with the party in local public office or on the ground) becomes more significant.

Identification of genetic variation influencing apolipoprotein E levels: Follow-up of genome-wide linkage scans in the GENOA study

Apolipoprotein E (ApoE) plays a major role in the metabolism of high density and low density lipoproteins (HDL and LDL). Its common protein isoforms (E2, E3, E4) are risk factors for coronary artery disease (CAD) and explain between 16 to 23% of the inter-individual variation in plasma apoE levels. Linkage analysis has been completed for plasma apoE levels in the GENOA study (Genetic Epidemiology Network of Atherosclerosis). After stratification of the population by lipoprotein levels and body mass index (BMI) to create more homogeneity with regard to biological context for apoE levels, Hispanic families showed significant linkage on chromosome 17q for two strata (LOD=2.93 at 104 cM for a low cholesterol group, LOD=3.04 at 111 cM for a low cholesterol, high HDLC group). Replication of 17q linkage was observed for apoB and apoE levels in the unstratified Hispanic and African-American populations, and for apoE levels in African-American families. Replication of this 17q linkage in different populations and strata provides strong support for the presence of gene(s) in this region with significant roles in the determination of inter-individual variation in plasma apoE levels. Through a positional and functional candidate gene approach, ten genes were identified in the 17q linked region, and 62 polymorphisms in these genes were genotyped in the GENOA families. Association analysis was performed with FBAT, GEE, and variance-component based tests followed by conditional linkage analysis. Association studies with partial coverage of TagSNPs in the gene coding for apolipoprotein H (APOH) were performed, and significant results were found for 2 SNPs (APOH_20951 and APOH_05407) in the Hispanic low cholesterol strata accounting for 3.49% of the inter-individual variation in plasma apoE levels. Among the other candidate genes, we identified a haplotype block in the ACE1 gene that contains two major haplotypes associated with apoE levels as well as total cholesterol, apoB and LDLC levels in the unstratified Hispanic population. Identifying genes responsible for the remaining 60% of inter-individual variation in plasma apoE level, will yield new insights into the understanding of genetic interactions involved in the lipid metabolism, and a more precise understanding of the risk factors leading to CAD. ^

Genoa, Italy, 1910 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Nuova pianta topografica della città e del porto di Genova : secondo gli ultimi lavori stradali con il percorso dei trams. It was published by A. P. Editore in 1910. Scale [ca. 1:7,000]. Covers Genoa, Italy. Map in Italian.The image inside the map neatline is georeferenced to the surface of the earth and fit to the European Datum 1950, Universal Transverse Mercator (UTM) Zone 32N projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads and stations, street railways, drainage, built-up areas and selected buildings, fortification, wharves, docks, gardens, and more. Relief shown by hachures.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Genoa, Italy, 1766 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Genova : nel solo giro delle sue mura vecchie con l'esposizione delle Chiese e luoghi principali, misurata a passi geometrici da Giacomo Brusco Ingegnere auit. It was published in 1766. Scale [ca. 1:1,250]. Covers Genoa, Italy. Map in Italian.The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'European Datum 1950 UTM Zone 32N' coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map.This map shows features such as roads, drainage, built-up areas and selected buildings, fortification, ground cover, wharves, and more. Relief shown pictorially. Includes index.This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Genoa, Italy, 1789 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Topografia del porto e cittá di Genova : nel solo ristretto delle sue mura vecchie, coll' indicazione delle chiese, e luoghi principali, delineata da Giacomo Bruschi Cap. Ingegniere 1789 ; Guidotto, scolpi. It was published by Ivone Gravier in 1789. Scale [ca. 1:5,000]. Covers Genoa, Italy. Map in Italian.The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'European Datum 1950 UTM Zone 32N' coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map.This map shows features such as roads, drainage, built-up areas and selected buildings, fortification, ground cover, wharves, and more. Relief shown by hachures. Includes index.This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Genoa Region, Italy, 1943 (Raster Image)

This layer is a georeferenced raster image of the historic paper topographic map entitled: Town plan of Genoa (Genova), drawn and photolithographed by War Office. It was published by the Army Map Service, U.S. Army in 1943. Scale 1:10,000. Covers the Genoa region, Italy.The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'European Datum 1950 UTM Zone 32N' coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map.This map shows features such as towns, villages, roads, railroads, drainage, built-up areas and selected buildings (schools, hospitals, factories, etc.), fortification, wharves, ground cover, power lines, aqueducts, and more. Relief shown by contours. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

War of Austrian Succession, Genoa Region, Italy, 1747 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carte géometrique de la ville et des environs de Gene : ou on voit l'expedition des Imperiaux et Piemontois contre le Genois et leurs alliez avec les differents postes, retranchements, attaques, déffenses, et mouvements de deux parties, le tout deßine sur le lieux, et de la maniere la plus exacte dans l'année 1747. It was published in 1747. Scale [ca. 1:38,980]. Covers the Genoa region, Italy. Map in French.The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'European Datum 1950 UTM Zone 32N' coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map.This map shows features such as towns and villages, roads, drainage, built-up areas and selected buildings, fortification and defenses, places of military interest related to the War of Austrian Succession 1740-1748, ground cover, and more. Relief shown by hachures. Includes index.This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.