960 resultados para Gaspare del Bufalo, 1786-1837.


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Este trabajo se inscribe en un proyecto de investigación, que también integran María Sierra y María Antonia Peña, sobre la idea de la representación política en la España liberal (1845-1890), del Ministerio de Ciencia y Tecnología con financiación FEDER (BHA2002-01007).

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Plancha nº 13 de la obra: Schola Italica Picturae. Número de la página en el ángulo superior derecho.

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Plancha nº 14 de la obra: Schola Italica Picturae. Número de la página en el ángulo superior derecho.

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Este artículo pertenece a un dossier monográfico titulado 'Enfermedad y medicina en la España del siglo XIX'

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In this paper, we investigated whether bcl-xL can be involved in the modulation of the angiogenic phenotype of human tumor cells. Using the ADF human glioblastoma and the M14 melanoma lines, and their derivative bcl-xL-overexpressing clones, we showed that the conditioned medium of bcl-xL transfectants increased in vitro endothelial cell functions, such as proliferation and morphogenesis, and in vivo vessel formation in Matrigel plugs, compared with the conditioned medium of control cells. Moreover, the overexpression of bcl-xL induced an increased expression of the proangiogenic interleukin-8 (CXCL8), both at the protein and mRNA levels, and an enhanced CXCL8 promoter activity. The role of CXCL8 on bcl-xL-induced angiogenesis was validated using CXCL8-neutralizing antibodies, whereas down-regulation of bcl-xL through antisense oligonucleotide or RNA interference strategies confirmed the involvement of bcl-xL on CXCL8 expression. Transient overexpression of bcl-xL led to extend this observation to other tumor cell lines with different origin, such as colon and prostate carcinoma. In conclusion, our results showed that CXCL8 modulation by bcl-xL regulates tumor angiogenesis, and they point to elucidate an additional function of bcl-xL protein.

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1. bd. Vermischte aufsätze. Erzählungen. Reisen.--2. bd. Dramaturgische blätter. Kritiken.--3. bd. Aus meinem tagebuche. Schliderungen aus Paris. Menzel, der Franzosenfresser. Französische schriften in uebersetzung. Aphorismen.--4. bd. Briefe aus Paris, 1830-1831.--5. bd. Briefe aus Paris, 1832-1833.

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Each volume has also special title page.

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Edited by Ludwig Börne.

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With: Q.D.B.V. orbis antiqui monumentis suis illustrati primi liniae / Jeremia Jacobo Oberlino. Argentorati : Ex Prelo Jonae Lorenz, [1772?]

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Mode of access: Internet.