G21 healthy region project part 1 : business plan

Executive Summary
Background
G21 Geelong Region Alliance (G21), through the partnership activities of the
G21 Health & Wellbeing Pillar, seeks to position health and wellbeing as a
central element to all regional planning processes and outcomes. As a result, G21 wanted to explore the potential application of the World Health
Organisation’s (WHO) ‘Healthy Cities’ approach across the region to provide a comprehensive framework and set of principles to inform future planning and decision-making.
With this aim, G21 commissioned Deakin University to undertake a 6-month
independent research project. The research project involved two stages:
Part 1: A Healthy Region Research Report involved scoping and determining:
- The suitability of the World Health Organisations (WHO) ‘Healthy Cities’
approach to the G21 region; and
- The capacity of G21 Geelong Region Alliance to be the organisation to
facilitate this approach across the region.

Dielectric Relaxation in SrLiB9O15 Glasses

Transparent SrLiB9O15 (SLBO) glasses were fabricated via the conventional melt-quenching technique. X-ray powder diffraction and differential thermal analysis carried out on the as-quenched samples confirmed their amorphous and glassy nature, respectively. The dielectric constants in the 100 Hz to 10 MHz frequency range for SLBO glasses were measured as a function of temperature (300–1023 K). The dielectric relaxation characteristics were rationalized using the electric modulus formalism. The electrode polarization effect was subtracted from the low-frequency dielectric constant to have an insight into the intrinsic dielectric behavior of SLBO glasses. The imaginary part of electric modulus spectra was modeled using an approximate solution of Kohlrausch–Williams–Watts relation. The dielectric constant for the as-quenched glass increased with increasing temperature and exhibited anomalies in the vicinity of the glass transition and crystallization temperatures.

Determinantes de la prima de riesgo en las emisiones de bonos de titulación hipotecaria en España (1993-2011)

Códigos JEL: G12, G21, G24, G32.

Procesos de prociclidad crediticia e impacto de la provisión estadística en España

Códigos JEL: G21, E32, E44

不同季节洱海沉积物硫酸盐还原菌类群与含量及分布变化

分析洱海沉积物硫酸盐还原菌类群与含量和分布的变化,为研究该区域环境污染物迁移转化提供相应的生物学信息。方法分别采用PCR 和荧光原位杂交法分析洱海沉积物硫酸盐还原菌类群和含量。结果春、秋季节洱海沉积物中共检出脱硫肠菌属、脱硫叶菌属、脱硫球菌属- 脱硫线菌属- 脱硫八叠菌属和脱硫弧菌属- 脱硫微菌属4 个类群的硫酸盐还原菌,其中脱硫弧菌- 脱硫微菌属只在秋季沉积物中检出;春季的硫酸盐还原菌为(0. 19 ±0. 25) ×104个·g21 ,从悬浮层至18 cm 深度均有检出;而秋季为(9. 95 ±12. 21) ×104 个·g21 ,从悬浮层至26 cm深度均有检出,二者差异有统计学意义( P < 0. 01) 。结论洱海沉积物硫酸盐还原菌类群较为丰富,脱硫弧菌属- 脱硫微菌属在春季沉积物中可能为不可育状态;硫酸盐还原菌类群分布复杂,每一类群均具有季节和分布的差异和优势性;秋季含量显著高于春季且分布更深;洱海沉积物中可能存在硫酸盐还原菌6 个类群以外的硫酸盐还原菌。

Synthesis of N3- and 2-NH2-substituted 6,7-diphenylpterins and their use as intermediates for the preparation of oligonucleotide conjugates designed to target photooxidative damage on single-stranded DNA representing the bcr-abl chimeric gene

Two 17-mer oligodeoxynucleotide-5'-linked-(6,7-diphenylpterin) conjugates, 2 and 3, were prepared as photosensitisers for targeting photooxidative damage to a 34-mer DNA oligodeoxynucleotide (ODN) fragment 1 representing the chimeric bcr-abl gene that is implicated in the pathogenesis of chronic myeloid leukaemia (CML). The base sequence in the 17-mer was 3'G G T A G T T A T T C C T T C T T5'. In the first of these ODN conjugates (2) the pterin was attached at its N3 atom, via a -(CH2)3OPO(OH)- linker, to the 5'-OH group of the ODN. Conjugate 2 was prepared from 2-amino-3-(3-hydroxypropyl)-6,7-diphenyl-4(3H)-pteridinone 10, using phosphoramidite methodology. Starting material 10 was prepared from 5-amino-7-methylthiofurazano[3,4-d]pyrimidine 4 via an unusual highly resonance stabilised cation 8, incorporating the rare 2H,6H-pyrimido[6,1-b][1,3]oxazine ring system. In the characterisation of 10 two pteridine phosphazenes, 15 and 29, were obtained, as well as new products containing two uncommon tricyclic ring systems, namely pyrimido[2,1-b]pteridine (20 and 24) and pyrimido[1,2-c]pteridine (27). In the second ODN conjugate the linker was -(CH2)5CONH(CH2)6OPO(OH)- and was attached to the 2-amino group of the pterin. In the preparation of 3, the N-hydroxysuccinimide ester 37 of 2-(5-carboxypentylamino)-6,7-diphenyl-4(3H)-pteridinone was condensed with the hexylamino-modified 17-mer. Excitation of 36 with near UV light in the presence of the single-stranded target 34-mer, 5'T G A C C A T C A A T A A G14 G A A G18 A A G21 C C C T T C A G C G G C C3' 1 caused oxidative damage at guanine bases, leading to alkali-labile sites which were monitored by polyacrylamide gel electrophoresis. Cleavage was observed at all guanine sites with a marked preference for cleavage at G14. In contrast, excitation of ODN-pteridine conjugate 2 in the presence of 1 caused oxidation of the latter predominantly at G18, with a smaller extent of cleavage at G15 and G14 (in the double-stranded portion) and G21. These results contrast with our previous observation of specific cleavage at G21 with ruthenium polypyridyl sensitisers, and suggest that a different mechanism, probably one involving Type 1 photochemical electron transfer, is operative. Much lower yields were found with the ODN-pteridine conjugate 3, perhaps as a consequence of the longer linker between the ODN and the pteridine in this case.