A de novo 1.1-1.6 Mb subtelomeric deletion of chromosome 20q13.33 in a patient with learning difficulties but without obvious dysmorphic features

We report on a de novo submicroscopic deletion of 20q13.33 identified by subtelomeric fluorescence in situ hybridization (FISH) in a 4-year-old girl with learning difficulties, hyperlaxity and strabismus, but without obvious dysmorphic features. Further investigations by array-based comparative genomic hybridization (array-CGH) and FISH analysis allowed us to delineate the smallest reported subterminal deletion of chromosome 20q, spanning a 1.1-1.6 Mb with a breakpoint localized between BAC RP5-887L7 and RP11-261N11. The genes CHRNA4 and KCNQ2 implicated in autosomal dominant epilepsy are included in the deletion interval. Subterminal 20q deletions as found in the present patient have, to our knowledge, only been reported in three patients. We review the clinical and behavioral phenotype of such "pure" subterminal 20q deletions.

Das Testament unter der Benennung einer Erbschaft : nach rabbinischen Quellen ; Hefte 1-6

Levi Bodenheimer

Ewaso Ngiro and Meru Ecosystems Elephant Corridors: Site 1-6

7 maps illustrating the elephant corridors in different sites of Ewaso Ngiro, Kenya.

Heat stress effects on ribulose-1,5-bisphosphate carboxylase/oxygenase, Rubisco binding protein and Rubisco activase in wheat leaves

Changes in chlorophyll content, ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) binding protein (RBP), Rubisco activase (RA), Rubisco large (LS) and small (SS) subunits, and electrolyte leakage were investigated in wheat leaf segments during heat stress (HS) for 1 h and for 24 h at 40 °C in darkness or in light, as well as after recovery from heat stress (HSR) for 24 h at 25 °C in light. The 24-h HS treatment in darkness decreased irreversibly photosynthetic pigments, soluble proteins, RBP, RA, Rubisco LS and SS. An increase in RA and RBP protein contents was observed under 24-h HS and HSR in light. This increase was in accordance with their role as chaperones and the function of RBP as a heat shock protein.

The mobility of Nb in rutile-saturated NaCl- and NaF-bearing aqueous fluids from 1-6.5 GPa and 300-800 °C

Rutile (TiO2) is an important host phase for high field strength elements (HFSE) such as Nb in metamorphic and subduction zone environments. The observed depletion of Nb in arc rocks is often explained by the hypothesis that rutile sequesters HFSE in the subducted slab and overlying sediment, and is chemically inert with respect to aqueous fluids evolved during prograde metamorphism in the forearc to subarc environment. However, field observations of exhumed terranes, and experimental studies, indicate that HFSE may be soluble in complex aqueous fluids at high pressure (i.e., >0.5 GPa) and moderate to high temperature (i.e., >300 degrees C). In this study, we investigated experimentally the mobility of Nb in NaCl- and NaF-bearing aqueous fluids in equilibrium with Nb-bearing rutile at pressure-temperature conditions applicable to fluid evolution in arc environments. Niobium concentrations in aqueous fluid at rutile saturation were measured directly by using a hydrothermal diamond-anvil cell (HDAC) and synchrotron X-ray fluorescence (SXRF) at 2.1 to 6.5 GPa and 300-500 degrees C, and indirectly by performing mass loss experiments in a piston-cylinder (PC) apparatus at similar to 1 GPa and 700-800 degrees C. The concentration of Nb in a 10 wt% NaCl aqueous fluid increases from 6 to 11 mu g/g as temperature increases from 300 to 500 degrees C, over a pressure range from 2.1 to 2.8 GPa, consistent with a positive temperature dependence. The concentration of Nb in a 20 wt% NaCl aqueous fluid varies from 55 to 150 mu g/g at 300 to 500 degrees C, over a pressure range from 1.8 to 6.4 GPa; however, there is no discernible temperature or pressure dependence. The Nb concentration in a 4 wt% NaF-bearing aqueous fluid increases from 180 to 910 mu g/g as temperature increases from 300 to 500 degrees C over the pressure range 2.1 to 6.5 GPa. The data for the F-bearing fluid indicate that the Nb content of the fluid exhibits a dependence on temperature between 300 and 500 degrees C at >= 2 GPa, but there is no observed dependence on pressure. Together, the data demonstrate that the hydrothermal mobility of Nb is strongly controlled by the composition of the fluid, consistent with published data for Ti. At all experimental conditions, however, the concentration of Nb in the fluid is always lower than coexisting rutile, consistent with a role for rutile in moderating the Nb budget of arc rocks.

Inhibition of photosynthesis by high temperature in oak (Quercus pubescens L.) leaves grown under natural conditions closely correlates with a reversible heat-dependent reduction of the activation state of ribulose-1,5-bisphosphate carboxylase/oxygenase

Inhibition of the net photosynthetic CO2 assimilation rate (Pn) by high temperature was examined in oak (Quercus pubescens L.) leaves grown under natural conditions. Combined measurements of gas exchange and chlorophyll (Chl) a fluorescence were employed to differentiate between inhibition originating from heat effects on components of the thylakoid membranes and that resulting from effects on photosynthetic carbon metabolism. Regardless of whether temperature was increased rapidly or gradually, Pn decreased with increasing leaf temperature and was more than 90% reduced at 45 °C as compared to 25 °C. Inhibition of Pn by heat stress did not result from reduced stomatal conductance (gs), as heat-induced reduction of gs was accompanied by an increase of the intercellular CO2 concentration (Ci). Chl a fluorescence measurements revealed that between 25 and 45 °C heat-dependent alterations of thylakoid-associated processes contributed only marginally, if at all, to the inhibition of Pn by heat stress, with photosystem II being remarkably well protected against thermal inactivation. The activation state of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) decreased from about 90% at 25 °C to less than 30% at 45 °C. Heat stress did not affect Rubisco per se, since full activity could be restored by incubation with CO2 and Mg2+. Western-blot analysis of leaf extracts disclosed the presence of two Rubisco activase polypeptides, but heat stress did not alter the profile of the activase bands. Inhibition of Pn at high leaf temperature could be markedly reduced by artificially increasing Ci. A high Ci also stimulated photosynthetic electron transport and resulted in reduced non-photochemical fluorescence quenching. Recovery experiments showed that heat-dependent inhibition of Pn was largely, if not fully, reversible. The present results demonstrate that in Q. pubescens leaves the thylakoid membranes in general and photosynthetic electron transport in particular were well protected against heat-induced perturbations and that inhibition of Pn by high temperature closely correlated with a reversible heat-dependent reduction of the Rubisco activation state.

Dithiothreitol triggers photooxidative stress and fragmentation of the large subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase in intact pea chloroplasts

In intact chloroplasts isolated from mature pea leaves (Pisum sativum L.), the large subunit (LSU) of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco, EC 4.1.1.39) was rapidly fragmented into several products upon illumination in the presence of 1 mM dithiothreitol (DTT). Very similar effects on LSU stability could be observed when illuminated chloroplasts were poisoned with cyanide which, like DTT, inhibits important plastid antioxidant enzymes, or when a light-dependent hydroxyl radical-producing system was added to the incubation medium. Moreover, DTT-stimulated light degradation of LSU was markedly delayed in the presence of scavengers of active oxygen species (AOS). It is therefore suggested that light degradation of LSU in the presence of DTT is mainly due to inhibition of the chloroplast antioxidant defense system and the subsequent accumulation of AOS in intact organelles. When chloroplasts were isolated from nonsenescent or senescent leaves, LSU remained very stable upon incubation without DTT, indicating that the antioxidant system was still functional in the isolated chloroplasts during leaf ageing. Our data support the notion that AOS might be important for the degradation of Rubisco in vivo under oxidative stress.

Na 1 Nachlass Max Horkheimer, 674 - Forschungsprojekte über Antisemitismus, Vorurteil, Autorität: Einzeluntersuchungen (p. IX 141.1-24- IX 142.1-6)

Bettelheim, Bruno; Janowitz, Morris: "A Study on Anxiety and Social Aggression Among Different Groups of War Veterans", 1945-1947; Über die Anfälligkeit der Veteranen für antisemitische Propaganda, Typoskript, englisch, 1 Blatt; "Preliminary Study on the Evaluation of Intolerance Propaganda". Typoskript, 29 Blatt; "Isolationg the Patterns of Intolerance". Typoskript, 30 Blatt; "Distribution of Ethic Intolerance". Typsokript, 18 Blatt; "The Social Characteristics of the Intolerant". Typoskript, 22 Blatt; "Addendum to Social Characteristics of the Intolerant". Typoskript, 16 Blatt; "Impact of War Experiences". Typoskript, 26 Blatt; "Pattern on Sterepotypes". Typoskript, 14 Blatt; "Appendix No. 1: Schedule of Questions Employed in Interview". Typoskript, 6 Blatt; "Appendix No. 2: The Verteran´s Comment on the Interview Situation". Typoskript, 7 Blatt; "Preliminary Report of the Evaluation of Tolerance Propaganda". Typoskript, 19 Blatt; Einleitung zur Beschreibung des Forschungsprojekts, Typoskript, englisch, 1 Blatt; "Instructions for Interviewers". Typoskript, 2 Blat; "Questionaire". Typoskrip, 10 Blatt; "Prupose of the Investigation". Typoskript, 4 Blatt; "Schedule for Interviewers". Typoskript, 6 Blatt; "Appendix: Chicago Veterans Project". Typoskript, 3 Blatt; Memodanden zu Sitzungen mit Bruno Bettelheim, Edward Shils und Theodor W. Adorno; Memorandum 03.04.1945, Typoskript, 2 Blatt; Memorandum 15.03.1945; a) Typoskript, 3 Blatt; b) Typoskript, 4 Blatt; Memorandum 07.03.1945; a) Typoskript, 5 Blatt; b) Typoskript, 6 Blatt; University of Chicago: 1 Brief an Max Horkheimer, Chicago, 29.10.1945; University of Chicago, 1 Brief an Edward Shils undBruno Bettelheim, Chicago, 05.07.1945; Fine, Benjamin: "For Education against Intolerance and Prejudice"; Sonderdruck aus: The Menorah Journal, 1944, Vol. XXXII, No. 2, S. 161-180; Drucksachen, Materialien, 10 Blatt; Ackerman, Nathan W.: zum 'Psychoanalyst Project', 1945-1946; "Towards a Dynamic definition of Anti-Semitism". Typoskript, 13 Blatt; "The Use of Psychoanalytic Case Histories for the Study of Anti-Semitism". Typoskript, 14 Blatt; "Case Material Summary", Tabelle, 5 Blatt; "From for the Collection of Clinical Data on Anti-Minority and Anti-Semitic Attitudes". Als Typoskript vervielfältigt, 5 Blatt; "Case 2". Typoskript, 5 Blatt; "Case 24". Typoskript, 8 Blatt;

Na 1 Nachlass Max Horkheimer, 685 - "Post War Antisemitism in Germany" (p. IX 147.1-6)

Gurland, A.R.L.: "Fight against Antisemitism within the Framwork of Germany's Education for Democracy. Draft Program", 1947. Als Typoskript vervielfältigt, 62 Blatt; Horkheimer, Max: "Momorandum on Post-War Antisemitism in Germany", 31.05.1945. Typoskript, 1 Blatt; Massing, Paul W.; Gurlach, A.R.L.: 2 Briefe mit Unterschrift an Max Horkheimer, ohne Ort, 1944; 1 Brief von Max Horkheimer, ohne Ort, 05.10.1944, 11 Blatt; Massig, Paul W.; Gurlach A.R.L.: "Some Remarks on Leo Löwenthals Memorandum" [September 1944]. Typoskript, 14 Blatt; [Löwenthal, Leo?]: "Post-War Antisemitism in Germany", a) Typoskript, 21 Blatt; b) Typoskript, 29 Blatt; Peck, Georg: "On the Problem of Antisemitism in Post-War Germany", 28.07.1943. Typoskript, 12 Blatt;