Memoirs of the life of Sir Stephen Fox ... to which is added a succinct account of his will and testament ... together with some memorable transactions relating to his son Charles Fox ...

Authorship has also been attributed to William Pittis.

Memoirs of the life of Sir Stephen Fox ... to which is added a succinct account of his will and testament ... together with some memorable transactions relating to his son Charles Fox ...

Authorship has also been attributed to William Pittis.

A declaration of the views of the Society of Friends : in relation to church government. Compiled principally from the writings of George Fox, Stephen Crisp, Robert Barclay and William Penn.

Smith I:770.

National working group meeting on ALK diagnostics in lung cancer

The global landscape of molecular testing is rapidly changing, with the recent publication of the International Association for the Study of Lung Cancer (IASLC)/College of American Pathologists (CAP) guidelines and the ALK Atlas. The IASLC/CAP guidelines recommend that tumors from patients with non-small cell lung cancer (NSCLC) be tested for ALK rearrangements in addition to epidermal growth factor receptor (EGFR) mutations. The spur for this recommendation is the availability of novel therapies that target these rearrangements. This article is based on coverage of a Pfizer-sponsored National Working Group Meeting on ALK Diagnostics in Lung Cancer, held around the 15th World Lung Cancer Conference, in Sydney on October 31, 2013. It is based on the presentations given by the authors at the meeting and the discussion that ensued. The content for this article was discussed and agreed on by the authors.

Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: in vitro and in vivo studies

Small interfering RNA (siRNA), antisense oligonucleotides (ODNs), ribozymes and DNAzymes have emerged as sequence-specific inhibitors of gene expression that may have therapeutic potential in the treatment of a wide range of diseases. Due to their rapid degradation in vivo, the efficacy of naked gene silencing nucleic acids is relatively short lived. The entrapment of these nucleic acids within biodegradable sustained-release delivery systems may improve their stability and reduce the doses required for efficacy. In this study, we have evaluated the potential in vitro and in vivo use of biodegradable poly (d,l-lactide-co-glycolide) copolymer (PLGA) microspheres as sustained delivery devices for ODNs, ribozyme, siRNA and DNA enzymes. In addition, we investigated the release of ODN conjugates bearing 5′-end lipophilic groups. The in vitro sustained release profiles of microsphere-entrapped nucleic acids were dependent on variables such as the type of nucleic acid used, the nature of the lipophilic group, and whether the nucleic acid used was single or double stranded. For in vivo studies, whole body autoradiography was used to monitor the bio-distribution of either free tritium-labelled ODN or that entrapped within PLGA microspheres following subcutaneous administration in Balb-c mice. The majority of the radioactivity associated with free ODN was eliminated within 24 h whereas polymer-released ODN persisted in organs and at the site of administration even after seven days post-administration. Polymer microsphere released ODN exhibited a similar tissue and cellular tropism to the free ODN. Micro-autoradiography analyses of the liver and kidneys showed similar bio-distribution for polymer-released and free ODNs with the majority of radioactivity being concentrated in the proximal convoluted tubules of the kidney and in the Kupffer cells of the liver. These findings suggest that biodegradable PLGA microspheres offer a method for improving the in vivo sustained delivery of gene silencing nucleic acids, and hence are worthy of further investigation as delivery systems for these macromolecules.

The works of William Makepeace Thackeray,

The illustrations are from drawings by the author, George Cruikshank, J. E. Millais, Richard Doyle, John Leech, and others.

英国証拠法

Mode of access: Internet.

Adventures of an attorney in search of practice /

Variously attributed to Sir George Stephen, Sir James Stephen, and Samuel Warren ; cf. BM, DNB.

A digest of the law of evidence as established in the United States : adapted from the English work of Sir James Fitzjames Stephen, with references to decisions of the federal and state courts /

Of the original 143 articles of evidence, 23 are entirely reworked, and 47 more altered to accomodate an American audience.

A modern symposium. Subjects: The soul and future life, by Frederic Harrison [and others] and, The influence upon morality of a decline in religious belief, by Sir James Fitzjames Stephen [and others]

Mode of access: Internet.

Fate of Sir John Franklin : the voyage of the 'Fox' in the Arctic seas in search of Franklin and his companions /

Author commanded the "Fox."

A modern symposium. Subjects: The soul and future life, by Frederic Harrison [and others] and, The influence upon morality of a decline in religious belief, by Sir James Fitzjames Stephen [and others]

Mode of access: Internet.

The life and letters of Lady Sarah Lennox, 1745-1826, daughter of Charles, 2nd Duke of Richmond, and successively the wife of Sir Thomas Charles Bunbury, Bart., and of the Hon. George Napier; also a short political sketch of the years 1760 to 1763,

Mode of access: Internet.