LAPATAX: A randomized phase II trial of FEC-docetaxel combined with lapatinib and/or trastuzumab as neoadjuvant therapy of HER2- positive breast cancer-EORTC 10054 trial.

Background: Patients with HER2 +ve breast cancer suitable for neoadjuvant chemotherapy (NAC) have been shown in a series of clinical trials to have the best outcome when treated with anthracyclines (A), taxanes (T), and trastuzumab (Tz). Recent evidence confirms that adjuvant Tz is more effective when given concomitantly rather than sequentially with T (Perez SABCS 2009). Whilst there remains uncertainty as to the most efficacious A-T regimen and duration of Tz, there is widespread use in Europe of FEC-D [3 cycles of 5-FU 500 mg/m2, epirubicin 100 mg/m2 and cyclophosphamide 500 mg/m2 (FEC100) followed by 3 cycles of docetaxel 100 mg/m2 (D) q3w] following the results of PACS-01. The advent of TKI anti-HER2 agents such as L could offer superior outcomes if combined with NAC. However, a phase I study in heavily pre-treated advanced breast cancer reported difficulties in combining lapatinib (L) with D 100 mg/m2 (LoRusso JCO 2008). Methods: EORTC 10054 is designed as a two-part study to compare FEC-D with either Tz, L or their combination as NAC for patients with HER2 +ve large operable or locally advanced breast cancer. Before and on-treatment frozen tumor and blood samples will be taken to better define which tumours are particularly sensitive to either Tz and/or L. Stage 1: (complete) a dose- finding study has confirmed that with primary prophylactic G-CSF, D 100 mg/m2 can be safely and effectively given with L 1,250 mg daily continuously. The dose-limiting toxicity was myelosuppression, and there was no significant diarrhoea or cardiac toxicity (ESMO 2009 abstr P- 5073). Stage 2: (opening Q1 2010) will enroll 150 patients from European centres into a 3-arm randomized trial whose primary endpoint is pathological complete response. All patients will receive FEC-D before primary surgery: 3 cycles of FEC (without anti-HER2 therapy) followed by 3 cycles of D plus either Tz (conventional weekly schedule), monotherapy L, or the combination of Tz and L, using doses based on the EGF100161 dose-finding study in 1st line metastatic therapy of D+L+Tz. After surgery all patients will receive standard 3-weekly Tz, radiotherapy and endocrine therapy as per local guidelines.

Hybrid turbo FEC/ARQ systems and distributed space-time coding for cooperative transmission

Cooperative transmission can be seen as a "virtual" MIMO system, where themultiple transmit antennas are in fact implemented distributed by the antennas both at the source and the relay terminal. Depending on the system design, diversity/multiplexing gainsare achievable. This design involves the definition of the type of retransmission (incrementalredundancy, repetition coding), the design of the distributed space-time codes, the errorcorrecting scheme, the operation of the relay (decode&forward or amplify&forward) and thenumber of antennas at each terminal. Proposed schemes are evaluated in different conditionsin combination with forward error correcting codes (FEC), both for linear and near-optimum(sphere decoder) receivers, for its possible implementation in downlink high speed packetservices of cellular networks. Results show the benefits of coded cooperation over directtransmission in terms of increased throughput. It is shown that multiplexing gains areobserved even if the mobile station features a single antenna, provided that cell wide reuse of the relay radio resource is possible.

Sommarnäs : J. Knutson fec.

Sommarnäs eli Sominainen on kartano Orimattilassa

Yokkis [i.e. Jokkis] gård : A. Lindeström fec.

Jokioisten kartano Tammelan pitäjässä (nykyinen kunta Jokioinen)

Nordenlund : P. A. Kruskopf fec.

Nordenlundin kartano (aikaisempi nimi Nuoramoinen) Sysmässä Nuoramoistenjärven rannalla

FEC-koulutuksen volyymin lisääminen uusien toteutusmallien avulla

Selvityksen tavoitteena on löytää KEKO/FEC-koulutusmallille uusia toteutusmalleja, joilla KEKO/FEC-koulutuksen kokonaisvolyymia voidaan nostaa merkittävästi nykyisestä. Volyymin nostamisella tarkoitetaan koulutettavien henkilöiden ja yritysten muodostamien parien lisäämistä. Uudet toimintamallit täydentävät nykyisiä käytäntöjä. Mallinnustyön metatavoitteena on, että nykyisellä KEKO/FEC-mallilla saavutettu kustannustehokkuus ei ainoastaan säily vaan paranee. Edelleen osana mallinnustyötä etsitään ideoita KEKO/FEC-koulutuksen laadulliseen kehittämiseen.

Producción espontánea e inducida del factor estimulador de colonias de granulocitos y macrófagos (FEC-GM), por las celulas mononucleares (CMN) de pacientes con lepra (por) Ana Cristina Cubillas Tejada

UANL

Degradación de pirazinamida mediante el proceso foto-fenton utilizando FeC?O? como fuente de hierro a pH 3, 4.5 y 6.

Tesis (Maestría en Ciencias con orientación en Química Analítica Ambiental) UANL, 2014.

Mauricio Amílcar López. Los cristianos y el cambio social en la Argentina. Mendoza, Acción Popular Ecuménica de Cuyo-FEC.,1989, t. I, 250 p.; 1992, t . l l , 250 p.

Fil: Fóscolo, Norma. Universidad Nacional de Cuyo

A Video-Aware FEC-Based Unequal Loss Protection Scheme for RTP Video Streaming

A video-aware unequal loss protection (ULP) system for protecting RTP video streaming in bursty packet loss networks is proposed. Just considering the relevance of the frame, the state of the channel and the bitrate constraints of the protection bitstream, our algorithm selects in real time the most suitable frames to be protected through forward error correction (FEC) techniques. It benefits from a wise RTP encapsulation that allows working at a frame level without requiring any further process than that of parsing RTP headers, so it is perfectly suitable to be included in commercial transmitters. The simulation results show how our proposed ULP technique outperforms non-smart schemes.

Inter-Packet Symbol Approach To Reed-Solomon FEC Codes For RTP-Multimedia Stream Protection

This paper presents an alternative Forward Error Correction scheme, based on Reed-Solomon codes, with the aim of protecting the transmission of RTP-multimedia streams: the inter-packet symbol approach. This scheme is based on an alternative bit structure that allocates each symbol of the Reed-Solomon code in several RTP-media packets. This characteristic permits to exploit better the recovery capability of Reed-Solomon codes against bursty packet losses. The performance of our approach has been studied in terms of encoding/decoding time versus recovery capability, and compared with other proposed schemes in the literature. The theoretical analysis has shown that our approach allows the use of a lower size of the Galois Fields compared to other solutions. This lower size results in a decrease of the required encoding/decoding time while keeping a comparable recovery capability. Finally, experimental results have been carried out to assess the performance of our approach compared to other schemes in a simulated environment, where models for wireless and wireline channels have been considered.

FEC journal of election administration.

Mode of access: Internet.