Elizabeth Mann

Elizabeth Mann

Probiotic modulation of dendritic cell function is influenced by ageing

Dendritic cells (DCs) are critical for the generation of T-cell responses. DC function may be modulated by probiotics, which confer health benefits in immunocompromised individuals, such as the elderly. This study investigated the effects of four probiotics, Bifidobacterium longum bv. infantis CCUG 52486, B. longum SP 07/3, L. rhamnosus GG (L.GG) and L. casei Shirota (LcS) on DC function in an allogeneic mixed leucocyte reaction (MLR) model, using DCs and T-cells from young and older donors in different combinations. All four probiotics enhanced expression of CD40, CD80 and CCR7 on both young and older DCs, but enhanced cytokine production (TGF-β, TNF-α) by old DCs only. LcS induced IL-12 and IFNγ production by DC to a greater degree than other strains, while Bifidobacterium longum bv. infantis CCUG 52486 favoured IL-10 production. Stimulation of young T cells in an allogeneic MLR with DC was enhanced by probiotic pretreatment of old DCs, which demonstrated greater activation (CD25) than untreated controls. However, pretreatment of young or old DCs with LPS or probiotics failed to enhance the proliferation of T-cells derived from older donors. In conclusion, this study demonstrates that ageing increases the responsiveness of DCs to probiotics, but this is not sufficient to overcome the impact of immunosenescence in the MLR.

School of Nursing Class of 2008

Top Row: Therese Adamowski, Anel Adamson, Michelle Ahleman, Brooke Babineau, Jennifer Ballough, Lisa Anne Beckman, Jennifer Bergeren, Tedra Boedigheimer, Mary Bonner, Genevieve Bott, Megan Bouwhuis, Mitchell Bradley, Rachel Brown, Katherine Bulson, Jennifer Calhoun, Carley Cebelak, Sarah Choinard

Row 2: Sarah Clevenger, Elizabeth Anne Conway, Erin Coughlin, Karie Curtis, Stephanie Curtis, Jodi Danhof, Rebecca Debri, Stacie Deleszek, Andrea Dehline, Amanda Devlin, Charlotte Dietrich, Angela Dodge, Elizabeth Dougherty, Ashley Doyle, Lindsay Driver, Nancy Duckworth, Kathy Dunnuck, Jennifer Dziadaio, Ellen English

Row 3: Kelly Esser, Amanda Fender, Lindsey Smith, Andrew Bradburn, Fallon Garfield Turner, Margaret Dembeck, Courtney Van Essen, Jessica paige Smith, Lauren Inouye, Jacqueline Dufek, Emily Klump, Amanda Jones, Tiffany Burrell, Deborah Mitchell, Emily Michel, Michelle Steen, Kirsten Thulin, Emily Hautamaki, Sheila Fender, Keith Ferguson

Row 4: Annie Fields, Jillian Fisher, Erin Flatley, Renee Forma, Aileen Franchi, Lindsey Freysinger, Sarah Fulgenzi, Beth Funnell, Andrea Galaviz, Lacey Garbo, Katherine Garcia, Lynn Garofalo

Row 5: Heather Gehrke, Nicole Genrich, Katie Giordano, Lindsey Glover, Andrea Godfrey, Jocelyn Gossman, Alana Greenberg, Julien Guttman, Sarah Halfmann, Kimberly Hanger, Allison Hanson, Stephanie Hecklin

Row 6: Geri Helminiak, Kristi Hershiser, Erin Hipp, Amanda Hoath, Tracy Hurlbutt, Nadya Indrei, Nisa Joorabchi, Katy Kerrigan, Layne Kiella, Jessica Kim, Samantha Klaiman, Jodi Knight, Laura Kovacic, Alicia Kreger

Row 7: Amanda Kretsch, Kimberly Kurzeja, Julie Lamonoff, Sarah Leirstein, Ashley Labb, Suzanne Loeb, Alessandra Lollini, Heather Loomis, Caroline Luke, Stephanie Maniquis, Elizabeth Mann, LaTasha Marable, Amanda McAdams, Mara McKinley

Row 8: Leah McLaughlin, Erin Migda, Scott Migut, Joane Nwoke, Lazarus Okammor, Brittany Pajewski, Judith Lynch-Sauer, Patricia Coleman-Burns, Bonnie Hagerty, Kathleen Potempa, Carol Loveland-Cherry, Carolyn Sampselle, Joanne Pohl, Sarah Pajtas, Maria Paneda, Jennifer Parker, Carol Peterson, Kimberley Peven, Rachel Poterek, Sarah Poucher

Row 9: Jannet Provost, Jessica Quigley, Nicole Rasmuson, Joanthan Reed, Sharon Reske, John Reves, Amy Riebe, Sara Riegner, Kelly Risicato, Christine Sabado, Stephanie Sargent, Jolene Schaefer, Erin Schroeder, Catherine Scott, Katherine See, Andrea Semaan, Jessica Shantz, Kathryn Sibbold, Kathleen Skendrovic, Aaron Smith, Elizabeth Stanton

Row 10: Mary Stewart, Ashley Strotbaum, Danielle Swartz, Janet Trost, Elizabeth Underwood, Lauren Underwood, Allison Vanhall, Brian Velker, Kristen Wells, Ryan Werblow, Jennifer Werden, David Westrin, Mallory Wiesen, Karen Wingrove, Amy Wright, Carrie Wright, Emily Wright, Minou Xie, Charles Zimmerman

Instituto Internacional del Océano

OrigenEl Instituto Internacional del Océano (IOI) fue establecido en la Universidad de Malta, en 1992. Uno de sus fundadores es la Profesora Elizabeth Mann Borgese, mecenas de la Oceanología e hija del ilustre premio Nóbel de la Literatura del año 1929 Tomas Mann...

Localization of a novel melanoma susceptibility locus to 1p22

Over the past 20 years, the incidence of cutaneous malignant melanoma (CMM) has increased dramatically worldwide. A positive family history of the disease is among the most established risk factors for CMM; it is estimated that 10% of CMM cases result from an inherited predisposition. Although mutations in two genes, CDKN2A and CDK4, have been shown to confer an increased risk of CMM, they account for only 20%-25% of families with multiple cases of CMM. Therefore, to localize additional loci involved in melanoma susceptibility, we have performed a genomewide scan for linkage in 49 Australian pedigrees containing at least three CMM cases, in which CDKN2A and CDK4 involvement has been excluded. The highest two-point parametric LOD score (1.82; recombination fraction [theta] 0.2) was obtained at D1S2726, which maps to the short arm of chromosome 1 (1p22). A parametric LOD score of 4.65 (theta = 0) and a nonparametric LOD score of 4.19 were found at D1S2779 in nine families selected for early age at onset. Additional typing yielded seven adjacent markers with LOD scores 13 in this subset, with the highest parametric LOD score, 4.95 (theta = 0) ( nonparametric LOD score 5.37), at D1S2776. Analysis of 33 additional multiplex families with CMM from several continents provided further evidence for linkage to the 1p22 region, again strongest in families with the earliest mean age at diagnosis. A nonparametric ordered sequential analysis was used, based on the average age at diagnosis in each family. The highest LOD score, 6.43, was obtained at D1S2779 and occurred when the 15 families with the earliest ages at onset were included. These data provide significant evidence of a novel susceptibility gene for CMM located within chromosome band 1p22.

eMelanoBase: An online locus-specific variant database for familial melanoma

A proportion of melanoma,prone individuals in both familial and non,familial contexts has been shown to carry inactivating mutations in either CDKN2A or, rarely, CDK4. CDKN2A is a complex locus that encodes two unrelated proteins from alternately spliced transcripts that are read in different frames. The alpha transcript (exons 1a, 2, and 3) produces the p16INK4A cyclin-dependent kinase inhibitor, while the beta transcript (exons 1beta and 2) is translated as p14ARF, a stabilizing factor of p53 levels through binding to MDM2. Mutations in exon 2 can impair both polypeptides and insertions and deletions in exons 1alpha, 1beta, and 2, which can theoretically generate p16INK4A,p14ARF fusion proteins. No online database currently takes into account all the consequences of these genotypes, a situation compounded by some problematic previous annotations of CDKN2A related sequences and descriptions of their mutations. As an initiative of the international Melanoma Genetics Consortium, we have therefore established a database of germline variants observed in all loci implicated in familial melanoma susceptibility. Such a comprehensive, publicly accessible database is an essential foundation for research on melanoma susceptibility and its clinical application. Our database serves two types of data as defined by HUGO. The core dataset includes the nucleotide variants on the genomic and transcript levels, amino acid variants, and citation. The ancillary dataset includes keyword description of events at the transcription and translation levels and epidemiological data. The application that handles users' queries was designed in the model,view. controller architecture and was implemented in Java. The object-relational database schema was deduced using functional dependency analysis. We hereby present our first functional prototype of eMelanoBase. The service is accessible via the URL www.wmi.usyd.e, du.au:8080/melanoma.html.

Elizabeth Bishop: Esboços de Uma Vida

Revista Lusófona de Línguas, Culturas e Tradução

Transtextualidade na tradução de "Der mann im fahrstuhl / The mann in the elevator"

In an age where Babel has turned into transcultural communication, an interlingual approach – i.e. in English and in French – to the translating process from German to Portuguese appeared pertinent. Aiming at a refinement of the translating competence, this process consists in contrasting different linguistic and literary strategies through an intercultural and multi-etymological perspective. Thus, we settled upon Heiner Müller‘s play Der Auftrag. Erinnerung an eine Revolution (1980), on which the composer Heiner Goebbels has based himself to textually and musically dramatize an excerpt, Der Mann im Farhstuhl / The Man in the Elevator. A transcription of such excerpt in its source language, German, as well as its translation into English (Carl Weber, 1984, Performing Arts Publications, New York) and French (Jean Jourdheuil, Heinz Schwarzinger, Editions Minuit, Paris) can be found in the booklet that accompanies the CD – edited in 1988 by ECD (München: Records GmbH). It should be emphasized that such a creation allows a framing of Müller‘s text into a musical scenography and, therefore, encourages an intersemiotic contrast. This experience enabled us to come up with a unique imagery of Müller‘s piece of writing, by means of its dramatic and musical conversion and, simultaneously, lead us to stretch our textual consciousness to a multitude of intra-, extra- and interlinguistic elements.

Os Buddenbrook de Thomas Mann

Prémio Nobel em 1929, Thomas Mann (1875-1955) publicou este romance em 1901. O livro retrata a vida de uma família alemã burguesa ao longo de quatro gerações no séc. XIX (1835-1877).

A curious herbal :containing five hundred cuts, of the most useful plants, which are now used in the practice of physick engraved on folio copper plates, after drawings taken from the life /by Elizabeth Blackwell. To which is added a short description of ye plants and their common uses in physick.

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