Elizabeth Mann

Elizabeth Mann

Probiotic modulation of dendritic cell function is influenced by ageing

Dendritic cells (DCs) are critical for the generation of T-cell responses. DC function may be modulated by probiotics, which confer health benefits in immunocompromised individuals, such as the elderly. This study investigated the effects of four probiotics, Bifidobacterium longum bv. infantis CCUG 52486, B. longum SP 07/3, L. rhamnosus GG (L.GG) and L. casei Shirota (LcS) on DC function in an allogeneic mixed leucocyte reaction (MLR) model, using DCs and T-cells from young and older donors in different combinations. All four probiotics enhanced expression of CD40, CD80 and CCR7 on both young and older DCs, but enhanced cytokine production (TGF-β, TNF-α) by old DCs only. LcS induced IL-12 and IFNγ production by DC to a greater degree than other strains, while Bifidobacterium longum bv. infantis CCUG 52486 favoured IL-10 production. Stimulation of young T cells in an allogeneic MLR with DC was enhanced by probiotic pretreatment of old DCs, which demonstrated greater activation (CD25) than untreated controls. However, pretreatment of young or old DCs with LPS or probiotics failed to enhance the proliferation of T-cells derived from older donors. In conclusion, this study demonstrates that ageing increases the responsiveness of DCs to probiotics, but this is not sufficient to overcome the impact of immunosenescence in the MLR.

School of Nursing Class of 2008

Top Row: Therese Adamowski, Anel Adamson, Michelle Ahleman, Brooke Babineau, Jennifer Ballough, Lisa Anne Beckman, Jennifer Bergeren, Tedra Boedigheimer, Mary Bonner, Genevieve Bott, Megan Bouwhuis, Mitchell Bradley, Rachel Brown, Katherine Bulson, Jennifer Calhoun, Carley Cebelak, Sarah Choinard

Row 2: Sarah Clevenger, Elizabeth Anne Conway, Erin Coughlin, Karie Curtis, Stephanie Curtis, Jodi Danhof, Rebecca Debri, Stacie Deleszek, Andrea Dehline, Amanda Devlin, Charlotte Dietrich, Angela Dodge, Elizabeth Dougherty, Ashley Doyle, Lindsay Driver, Nancy Duckworth, Kathy Dunnuck, Jennifer Dziadaio, Ellen English

Row 3: Kelly Esser, Amanda Fender, Lindsey Smith, Andrew Bradburn, Fallon Garfield Turner, Margaret Dembeck, Courtney Van Essen, Jessica paige Smith, Lauren Inouye, Jacqueline Dufek, Emily Klump, Amanda Jones, Tiffany Burrell, Deborah Mitchell, Emily Michel, Michelle Steen, Kirsten Thulin, Emily Hautamaki, Sheila Fender, Keith Ferguson

Row 4: Annie Fields, Jillian Fisher, Erin Flatley, Renee Forma, Aileen Franchi, Lindsey Freysinger, Sarah Fulgenzi, Beth Funnell, Andrea Galaviz, Lacey Garbo, Katherine Garcia, Lynn Garofalo

Row 5: Heather Gehrke, Nicole Genrich, Katie Giordano, Lindsey Glover, Andrea Godfrey, Jocelyn Gossman, Alana Greenberg, Julien Guttman, Sarah Halfmann, Kimberly Hanger, Allison Hanson, Stephanie Hecklin

Row 6: Geri Helminiak, Kristi Hershiser, Erin Hipp, Amanda Hoath, Tracy Hurlbutt, Nadya Indrei, Nisa Joorabchi, Katy Kerrigan, Layne Kiella, Jessica Kim, Samantha Klaiman, Jodi Knight, Laura Kovacic, Alicia Kreger

Row 7: Amanda Kretsch, Kimberly Kurzeja, Julie Lamonoff, Sarah Leirstein, Ashley Labb, Suzanne Loeb, Alessandra Lollini, Heather Loomis, Caroline Luke, Stephanie Maniquis, Elizabeth Mann, LaTasha Marable, Amanda McAdams, Mara McKinley

Row 8: Leah McLaughlin, Erin Migda, Scott Migut, Joane Nwoke, Lazarus Okammor, Brittany Pajewski, Judith Lynch-Sauer, Patricia Coleman-Burns, Bonnie Hagerty, Kathleen Potempa, Carol Loveland-Cherry, Carolyn Sampselle, Joanne Pohl, Sarah Pajtas, Maria Paneda, Jennifer Parker, Carol Peterson, Kimberley Peven, Rachel Poterek, Sarah Poucher

Row 9: Jannet Provost, Jessica Quigley, Nicole Rasmuson, Joanthan Reed, Sharon Reske, John Reves, Amy Riebe, Sara Riegner, Kelly Risicato, Christine Sabado, Stephanie Sargent, Jolene Schaefer, Erin Schroeder, Catherine Scott, Katherine See, Andrea Semaan, Jessica Shantz, Kathryn Sibbold, Kathleen Skendrovic, Aaron Smith, Elizabeth Stanton

Row 10: Mary Stewart, Ashley Strotbaum, Danielle Swartz, Janet Trost, Elizabeth Underwood, Lauren Underwood, Allison Vanhall, Brian Velker, Kristen Wells, Ryan Werblow, Jennifer Werden, David Westrin, Mallory Wiesen, Karen Wingrove, Amy Wright, Carrie Wright, Emily Wright, Minou Xie, Charles Zimmerman

Instituto Internacional del Océano

OrigenEl Instituto Internacional del Océano (IOI) fue establecido en la Universidad de Malta, en 1992. Uno de sus fundadores es la Profesora Elizabeth Mann Borgese, mecenas de la Oceanología e hija del ilustre premio Nóbel de la Literatura del año 1929 Tomas Mann...

Audience members watching the opening ceremonies of the Heidelberg festival, with opening speech given by Thomas Mann.

Typed caption: Festakt in der Stadthalle zur Eroeffnung der Heidelberger Festpiele 1929. Thomas Mann hielt die Festrede. Unsere Aufnahme zeigt einen Ausschnitt aus der Festversammlung, an der die geistige Prominenz Heidelbergs und zahlreiche bedeutende Persoenlichkeiten des deutschen Kulturlebends teilnahmen. Von links nach rechts in der 1. Reihe: Rene Schickele, Rudolf Rittner, Gustav Hargung, Prof. Dr. Martin Dibelius, Gerhart Hauptmann, Dr. Rudolf H. Goldschmidt, Oberbuergermeister Dr. Neinhaus, Thomas Mann und Frau, Kultusminister Leers, Rudolf G. Binding; In der 3. Reihe: Oberbaurat L. Schmieder, Nobelpreistraeger Dr. F. Bergius, Bankdirektor Fremerey, Prof. Hellpach, Prof. Radbruch

Deletion mapping suggests that the 1p22 melanoma susceptibility gene is a tumor suppressor localized to a 9-Mb interval

Loss of the short arm of chromosome 1 is frequently observed in many tumor types, including melanoma. We recently localized a third melanoma susceptibility locus to chromosome band 1p22. Critical recombinants in linked families localized the gene to a 15-Mb region between D1S430 and D1S2664. To map the locus more finely we have performed studies to assess allelic loss across the region in a panel of melanomas from 1p22-linked families, sporadic melanomas, and melanoma cell lines. Eighty percent of familial melanomas exhibited loss of heterozygosity (LOH) within the region, with a smallest region of overlapping deletions (SRO) of 9 Mb between D1S207 and D1S435. This high frequency of LOH makes it very likely that the susceptibility locus is a tumor suppressor. In sporadic tumors, four SROs were defined. SRO1 and SRO2 map within the critical recombinant and familial tumor region, indicating that one or the other is likely to harbor the susceptibility gene. However, SRO3 may also be significant because it overlaps with the markers with the highest 2-point LOD score (D1S2776), part of the linkage recombinant region, and the critical region defined in mesothelioma. The candidate genes PRKCL2 and GTF2B, within SRO2, and TGFBR3, CDC7, and EVI5, in a broad region encompassing SRO3, were screened in 1p22-linked melanoma kindreds, but no coding mutations were detected. Allelic loss in melanoma cell lines was significantly less frequent than in fresh tumors, indicating that this gene may not be involved late in progression, such as in overriding cellular senescence, necessary for the propagation of melanoma cells in culture.

Analysing the Sri Lankan conflict using Michael Mann's four-dimensional model of social power

This thesis provides an overview of the Sri Lankan civil war with a view to identifying some of the factors that contributed to the dispute between the Sri Lankan government and the Liberation Tigers of Tamil Eelam. It adopts a multi-causal explanation of the conflict by reference to the theories of social power developed by Michael Mann. The conflict has been variously described as an ethnic or political conflict, or has been characterised as a determined by a number of interacting factors (including colonialism, ethnicity, religion, economy, politics and globalisation). Mann’s four-dimensional model of social power is deployed to analyse the causal relationships, together with their inter-connections, which clarify the origins of the dispute. It argues that Mann’s theoretical framework helps to highlight some of the interconnected elements that contributed to the conflict.

Review : "Spatial planning and climate change" by Elizabeth Wilson and Jake Piper

This timely and thorough book seeks to provide evidence-based assessments of ways in which spatial planning may develop and deliver new strategies for addressing both the causes and impacts of climate change. The authors state that much of the analysis is informed by experiences and learning from their own involvements with climate change projects. The book aims to be relevant to a wide audience and nominates its intended readership to include planning practitioners, scholars, post-graduate students of built environment courses, politicians and the ‘interested’ public. In this regard, the authors skilfully deliver with a comprehensive and accessible dissemination of the nexus between spatial planning and climate change...

'A small space of chaos’ : Elizabeth Grosz’s chaos, territory, art : Deleuze and the framing of the earth

Review of Elizabeth Grosz’s Chaos, Territory, Art: Deleuze and the Framing of the Earth

Senator Elizabeth Warren fights the White House over the secret Trans-Pacific Partnership #TPP #TPPA

In his visit to the G20 in Brisbane, President Barack Obama sought to promote his ambitious Pacific Rim trade agreement — the Trans-Pacific Partnership (TPP). He told an audience at the University of Queensland: We’ll keep leading the effort to realize the Trans-Pacific Partnership to lower barriers, open markets, export goods, and create good jobs for our people. But with the 12 countries of the TPP making up nearly 40 percent of the global economy, this is also about something bigger. It is our chance to put in place new, high standards for trade in the 21st century that uphold our values. So, for example, we are pushing new standards in this trade agreement, requiring countries that participate to protect their workers better and to protect the environment better, and protect intellectual property that unleashes innovation, and baseline standards to ensure transparency and rule of law.

Transition of self: Repositioning the celebrity brand through social media—The case of Elizabeth Gilbert

Transitioning the personal brand from one representation to another is sometimes necessary, particularly within the public eye. Marketing literature regarding celebrities focuses on brand endorsement (see for example Till, 1998 or Erdogan, 1999), rather than the positioning of a celebrity brand. Furthermore, the role of social media in strengthening the celebrity brand has received limited attention in the literature outside of political marketing (see for example Crawford, 2009 and Grant, Moon and Grant, 2010). This study focuses on the brand of “Elizabeth Gilbert,” author of the bestseller memoir, Eat, Pray, Love (2006). Through critical discourse analysis, the way the author has used social media to reposition her celebrity brand at the time of the launch of her new novel, ‘The Signature of All Things’ (2013) is examined. This study focuses on the use of social media by celebrities to strengthen the celebrity brand.

Kurt Hirschfeld (left) speaking with Thomas Mann Portraits Groups Men

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Studio Portrait of Elizabeth, Kurt and Hal Godshaw (Gottschalk).

From left to right: Elizabeth, Kurt, Hal Godshaw

Elizabeth Engel nee Benjamin-Rasmussen in her home; Silver Springs, Maryland Portraits Women

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Elizabeth Engel nee Benjamin-Rasmussen with her daughter Dorel Hall nee Engel in Elizabeth's home; Silver Springs, Maryland Portraits Family

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