Infants' selective attention to faces and prosody of speech: The roles of intersensory redundancy and exploratory time

One of the overarching questions in the field of infant perceptual and cognitive development concerns how selective attention is organized during early development to facilitate learning. The following study examined how infants' selective attention to properties of social events (i.e., prosody of speech and facial identity) changes in real time as a function of intersensory redundancy (redundant audiovisual, nonredundant unimodal visual) and exploratory time. Intersensory redundancy refers to the spatially coordinated and temporally synchronous occurrence of information across multiple senses. Real time macro- and micro-structural change in infants' scanning patterns of dynamic faces was also examined. ^ According to the Intersensory Redundancy Hypothesis, information presented redundantly and in temporal synchrony across two or more senses recruits infants' selective attention and facilitates perceptual learning of highly salient amodal properties (properties that can be perceived across several sensory modalities such as the prosody of speech) at the expense of less salient modality specific properties. Conversely, information presented to only one sense facilitates infants' learning of modality specific properties (properties that are specific to a particular sensory modality such as facial features) at the expense of amodal properties (Bahrick & Lickliter, 2000, 2002). ^ Infants' selective attention and discrimination of prosody of speech and facial configuration was assessed in a modified visual paired comparison paradigm. In redundant audiovisual stimulation, it was predicted infants would show discrimination of prosody of speech in the early phases of exploration and facial configuration in the later phases of exploration. Conversely, in nonredundant unimodal visual stimulation, it was predicted infants would show discrimination of facial identity in the early phases of exploration and prosody of speech in the later phases of exploration. Results provided support for the first prediction and indicated that following redundant audiovisual exposure, infants showed discrimination of prosody of speech earlier in processing time than discrimination of facial identity. Data from the nonredundant unimodal visual condition provided partial support for the second prediction and indicated that infants showed discrimination of facial identity, but not prosody of speech. The dissertation study contributes to the understanding of the nature of infants' selective attention and processing of social events across exploratory time.^

A alexitimia na categorização de emoções em expressões faciais dinâmicas

A alexitimia é o termo usado para caracterizar as pessoas com défices no processamento, na compreensão e na descrição de emoções. Definida também como um traço de personalidade multifatorial, a alexitimia tem uma prevalência de 10% na população em geral e está associada a uma menor qualidade de vida. Apesar de este estudo incidir-se numa população saudável, a alexitimia está frequentemente associada a patologias físicas e perturbações mentais. O objetivo deste estudo consistiu em verificar a influência da alexitimia na categorização das expressões faciais emocionais, numa tarefa de apresentação de faces dinâmicas. 87 participantes com diferentes índices de alexitimia completaram uma tarefa que consistia na apresentação de faces dinâmicas cujo o intuito era categorizar as expressões faciais de raiva, nojo e alegria. A precisão das respostas e os níveis de intensidade emocional foram manipulados. Os resultados indicaram que os indivíduos, no geral, identificaram mais precisamente e com menores níveis de intensidade emocional a expressão de alegria comparativamente com as expressões negativas (raiva e nojo). Verificou-se também diferenças significativas entre a alexitimia e as expressões faciais emocionais relativamente à precisão na categorização. Deste modo, foi possível verificar neste estudo, que indivíduos com altos níveis de alexitimia foram significativamente menos precisos na identificação da expressão facial de raiva comparativamente com indivíduos com baixos níveis de alexitimia.

Abnormal Amygdala-Prefrontal Effective Connectivity to Happy Faces Differentiates Bipolar from Major Depression

Background: Bipolar disorder is frequently misdiagnosed as major depressive disorder, delaying appropriate treatment and worsening outcome for many bipolar individuals. Emotion dysregulation is a core feature of bipolar disorder. Measures of dysfunction in neural systems supporting emotion regulation might therefore help discriminate bipolar from major depressive disorder. Methods: Thirty-one depressed individuals-15 bipolar depressed (BD) and 16 major depressed (MDD), DSM-IV diagnostic criteria, ages 18-55 years, matched for age, age of illness onset, illness duration, and depression severity-and 16 age- and gender-matched healthy control subjects performed two event-related paradigms: labeling the emotional intensity of happy and sad faces, respectively. We employed dynamic causal modeling to examine significant among-group alterations in effective connectivity (EC) between right- and left-sided neural regions supporting emotion regulation: amygdala and orbitomedial prefrontal cortex (OMPFC). Results: During classification of happy faces, we found profound and asymmetrical differences in EC between the OMPFC and amygdala. Left-sided differences involved top-down connections and discriminated between depressed and control subjects. Furthermore, greater medication load was associated with an amelioration of this abnormal top-down EC. Conversely, on the right side the abnormality was in bottom-up EC that was specific to bipolar disorder. These effects replicated when we considered only female subjects. Conclusions: Abnormal, left-sided, top-down OMPFC-amygdala and right-sided, bottom-up, amygdala-OMPFC EC during happy labeling distinguish BD and MDD, suggesting different pathophysiological mechanisms associated with the two types of depression.

Neural substrates of social emotion regulation: a FMRI study on imitation and expressive suppression to dynamic facial signals.

Emotion regulation is crucial for successfully engaging in social interactions. Yet, little is known about the neural mechanisms controlling behavioral responses to emotional expressions perceived in the face of other people, which constitute a key element of interpersonal communication. Here, we investigated brain systems involved in social emotion perception and regulation, using functional magnetic resonance imaging (fMRI) in 20 healthy participants. The latter saw dynamic facial expressions of either happiness or sadness, and were asked to either imitate the expression or to suppress any expression on their own face (in addition to a gender judgment control task). fMRI results revealed higher activity in regions associated with emotion (e.g., the insula), motor function (e.g., motor cortex), and theory of mind (e.g., [pre]cuneus) during imitation. Activity in dorsal cingulate cortex was also increased during imitation, possibly reflecting greater action monitoring or conflict with own feeling states. In addition, premotor regions were more strongly activated during both imitation and suppression, suggesting a recruitment of motor control for both the production and inhibition of emotion expressions. Expressive suppression (eSUP) produced increases in dorsolateral and lateral prefrontal cortex typically related to cognitive control. These results suggest that voluntary imitation and eSUP modulate brain responses to emotional signals perceived from faces, by up- and down-regulating activity in distributed subcortical and cortical networks that are particularly involved in emotion, action monitoring, and cognitive control.

A speculative systems model of the dynamic interaction among students, faculty and administration in the community college, with particular reference to intrinsic motivation and the teacher-administrator interface

The challenge the community college faces in helping meet the needs of the living open system of society is examined in this study. It is postulated that internalization student outcomes are required by society to reduce entropy and remain self-renewing. Such behavior is characterized as having an intrinsically motivated energy source and displays the seeking and conquering of challenge, the development of reflective knowledge and skill, full use of all capabilities, internal control, growth orientation, high self-esteem, relativistic thinking and competence. The development of a conceptual systems model that suggests how transactions among students, faculty and administration might occur to best meet the needs of internalization outcomes in students, and intrinsic motivation in faculty is a major purpose of this study. It is a speculative model that is based on a synthesis of a wide variety of variables. Empirical evidence, theoretical considerations, and speculative ideas are gathered together from researchers and theoretici.ans who are working on separate answers to questions of intrinsic motivation, internal control and environments that encourage their development. The model considers the effect administrators·have on faculty anq the corresponding effect faculty may have on students. The major concentration is on the administrator--teacher interface.For administrators the model may serve as a guide in planning effective transactions, and establishing system goals. The teacher is offered a means to coordinate actions toward a specific overall objective, and the administrator, teacher and researcher are invited to use the model to experiment, innovate, verify the assumptions on which the model is based, and raise additional hypotheses. Goals and history of the community colleges in Ontario are examined against current problems, previous progress and open system thinking. The nature of the person as a five part system is explored with emphasis on intrinsic motivation. The nature, operation, conceptualization, and value of this internal energy source is reviewed in detail. The current state of society, education and management theory are considered and the value of intrinsically motivating teaching tasks together with "system four" leadership style are featured. Evidence is reviewed that suggests intrinsically motivated faculty are needed, and "system four" leadership style is the kind of interaction-influence system needed to nurture intrinsic motivation in faculty.

Variation in the human Cannabinoid Receptor (CNR1) gene modulates gaze duration for happy faces

BACKGROUND: Humans from an early age look longer at preferred stimuli, and also typically look longer at facial expressions of emotion, particularly happy faces. Atypical gaze patterns towards social stimuli are common in Autism Spectrum Conditions (ASC). However, it is unknown if gaze fixation patterns have any genetic basis. In this study, we tested if variations in the cannabinoid receptor 1 (CNR1) gene are associated with gaze duration towards happy faces. This gene was selected because CNR1 is a key component of the endocannabinoid system, involved in processing reward, and in our previous fMRI study we found variations in CNR1 modulates the striatal response to happy (but not disgust) faces. The striatum is involved in guiding gaze to rewarding aspects of a visual scene. We aimed to validate and extend this result in another sample using a different technique (gaze tracking). METHODS: 30 volunteers (13 males, 17 females) from the general population observed dynamic emotion expressions on a screen while their eye movements were recorded. They were genotyped for the identical four SNPs in the CNR1 gene tested in our earlier fMRI study. RESULTS: Two SNPs (rs806377 and rs806380) were associated with differential gaze duration for happy (but not disgust) faces. Importantly, the allelic groups associated with greater striatal response to happy faces in the fMRI study were associated with longer gaze duration for happy faces. CONCLUSIONS: These results suggest CNR1 variations modulate striatal function that underlies the perception of signals of social reward such as happy faces. This suggests CNR1 is a key element in the molecular architecture of perception of certain basic emotions. This may have implications for understanding neurodevelopmental conditions marked by atypical eye contact and facial emotion processing, such as ASC.

As duas faces das técnicas de gestão: aprendizagem e inovação evidências de empresa do setor siderúrgico no Brasil

Ao longo dos últimos 20 anos tem havido uma profusão de estudos que examinam, no âmbito de empresas, a contribuição dos mecanismos de aprendizagem e da adoção de técnicas de gestão para o processo de acumulação tecnológica. No entanto, ainda são escassos os estudos que examinem, de maneira conjunta e sob uma perspectiva dinâmica, o relacionamento entre a adoção de técnicas de gestão, mecanismos de aprendizagem e trajetórias de acumulação de capacidades tecnológicas. Mais que isto, faltam estudos que examinem o duplo papel das técnicas de gestão, ora como parte do estoque de capacidades tecnológicas, ora como um processo de aprendizagem tecnológica em si. Esta dissertação objetiva oferecer uma contribuição para preencher esta lacuna neste campo de estudo. O enfoque desta dissertação deriva de observações empíricas, realizadas em empresas, e inspira-se no clássico estudo Innovation and Learning: the two faces of R&D, de Cohen e Levinthal (1989). Assim a dissertação baseia-se em um estudo de caso individual, realizado em uma empresa do setor siderúrgico no Brasil, no período de 1984 a 2008, examinando estas questões à luz de modelos analíticos disponíveis na literatura internacional. Neste sentido, adotou-se o entendimento de capacidade tecnológica como o conjunto de recursos necessários para gerar e gerir mudanças tecnológicas, sendo construída e acumulada de forma gradual, a partir do engajamento em processos de aprendizagem e da coordenação de bases de conhecimentos acumulados em diferentes dimensões, simbioticamente relacionadas. As métricas utilizadas identificam tipos e níveis de capacidade tecnológica para diferentes funções e identifica quatro tipos de processos de aprendizagem tecnológica e os avalia em termos de suas características-chave. Tomando-se por base evidências empíricas qualitativas e quantitativas, colhidas em primeira mão, a base de trabalho de campo, este estudo verificou que: 1. A empresa acumulou níveis inovativos de capacidades tecnológicas em todas as funções examinadas, sendo o nível Inovativo Intermediário (Nível 5) nas funções Engenharia de Projetos (de forma incompleta) e Equipamentos e o nível Intermediário Avançado (Nível 6) nas funções Processos e Organização da Produção e Produtos. 2. Os mecanismos de aprendizagem subjacentes à acumulação destes níveis de capacidade tecnológica apresentaram resultados relevantes em termos de suas características-chave, principalmente no que diz respeito à variedade e intensidade: de 24 mecanismos em 1984 para um total de 59 em 2008, com uma variação de 145,8%, e com 56 dos 59 mecanismos (94,92%) utilizados atualmente de forma sistemática. 3. O período compreendido entre os anos de 1990 e 2004, no qual foram implementadas as técnicas de gestão estudadas, exceto o Plano de Sugestões, se caracteriza por apresentar a maior taxa de acumulação de capacidades tecnológicas e por dar início à utilização da quase totalidade dos 35 novos mecanismos de aprendizagem incorporados pela empresa após o início de suas operações (1984). E que as técnicas de gestão estudadas: 1. Colaboraram para o processo de aprendizagem tecnológica da AMBJF, principalmente pela necessidade de se: (i) incorporar novos mecanismos de aprendizagem que lhe permitissem acumular, antecipadamente, a base de conhecimentos necessária à implementação das técnicas de gestão estudadas; (ii) coordenar um número maior de mecanismos que dessem o adequado suporte ao aumento da complexidade de seu Sistema de Gestão Integrada (SOl). 2. Ampliaram, por si, o estoque de capacidades tecnológicas da empresa, maIS especificamente em sua dimensão organizacional, a partir da acumulação de conhecimento em procedimentos, instruções de trabalho, manuais, processos e fluxos de gestão e de produção, dentre outros. Desta forma, os resultados aqui encontrados confirmam que a adoção e a implementação das técnicas de gestão estudadas contribuíram com e influenciaram o processo de aprendizagem tecnológica e a trajetória de acumulação tecnológica da empresa, ao mesmo tempo, exercendo, portanto, um duplo papel na organização. Esta conclusão nos leva a um melhor entendimento do tema e pode contribuir para a compreensão de ações políticas e gerenciais que possam acelerar a acumulação de capacidades tecnológicas, entendendo a relevância das técnicas de gestão menos em termos de sua "mera" adoção e mais do seu processo de implementação.

As duas faces da Petrobrás: a persistente dinâmica da empresa estatal no arranjo institucional brasileiro

A presente dissertação analisará a persistente dinâmica da Petróleo Brasileiro S.A. – Petrobras – no arranjo institucional brasileiro. O objetivo é identificar se essa permanência foi acompanhada de mudanças na estrutura macro e microjurídica da empresa estatal que promoveram a sua adaptação às alterações da relação Estado e mercado promovidas por reformas institucionais. O trabalho parte do pressuposto de que, na recente evolução histórica brasileira, quatro correlações de forças promoveram reformas jurídicas que alteraram a relação Estado e mercado em quatro diferentes períodos: (i) da Era Vargas ao governo Juscelino Kubitschek; (ii) do golpe militar ao processo de redemocratização; (iii) do governo Fernando Collor ao término do governo Fernando Henrique Cardoso; e (iv) do início do governo Lula até o momento da elaboração deste trabalho. Para desenvolver esse precedente, o primeiro capítulo analisará o modo e a intensidade da intervenção direta do Estado no setor produtivo para identificar as características da relação Estado e mercado nos períodos. Os capítulos subsequentes se deterão à análise da estrutura da Petrobras na esfera microjurídica – organização societária – e macrojurídica – articulação da empresa estatal com outros agentes públicos e privados – em cada um dos quatro períodos delimitados no capítulo anterior. O segundo capítulo descreverá institucionalmente a Petrobras durante seus primeiros dez anos. O terceiro capítulo identificará as mudanças institucionais promovidas na empresa estatal durante o regime militar. O quarto capítulo disporá sobre as alterações jurídicas na Petrobras promovidas pela Reforma do Estado. Por fim, o quinto capítulo tratará das mais recentes mudanças institucionais da empresa estatal decorrente da descoberta da vasta reserva de petróleo denominada pré-sal.

Dynamic gamma frequency feedback coupling between higher and lower order visual cortices underlies perceptual completion in humans

To perceive a coherent environment, incomplete or overlapping visual forms must be integrated into meaningful coherent percepts, a process referred to as ?Gestalt? formation or perceptual completion. Increasing evidence suggests that this process engages oscillatory neuronal activity in a distributed neuronal assembly. A separate line of evidence suggests that Gestalt formation requires top-down feedback from higher order brain regions to early visual cortex. Here we combine magnetoencephalography (MEG) and effective connectivity analysis in the frequency domain to specifically address the effective coupling between sources of oscillatory brain activity during Gestalt formation. We demonstrate that perceptual completion of two-tone ?Mooney? faces induces increased gamma frequency band power (55?71 Hz) in human early visual, fusiform and parietal cortices. Within this distributed neuronal assembly fusiform and parietal gamma oscillators are coupled by forward and backward connectivity during Mooney face perception, indicating reciprocal influences of gamma activity between these higher order visual brain regions. Critically, gamma band oscillations in early visual cortex are modulated by top-down feedback connectivity from both fusiform and parietal cortices. Thus, we provide a mechanistic account of Gestalt perception in which gamma oscillations in feature sensitive and spatial attention-relevant brain regions reciprocally drive one another and convey global stimulus aspects to local processing units at low levels of the sensory hierarchy by top-down feedback. Our data therefore support the notion of inverse hierarchical processing within the visual system underlying awareness of coherent percepts.

The Sarkozy effect: France’s new presidential dynamic

The election on 6 May 2007 of Nicolas Sarkozy as President of the Republic ushered in the promise of a new era in France. Sarkozy’s presidency follows those of the Socialist François Mitterrand (1981-95) and the neo-Gaullist Jacques Chirac (1995-2007), who together occupied France’s highest political office for more than a quarter-century. From the outset, Sarkozy’s presidential campaign was predicated on the need for change in France, for a “rupture” with the past; and his emphatic victory against the Socialist Ségolène Royal gave him a mandate to effect this. The legislative elections of June 2007, by assuring a strong majority in the National Assembly for Sarkozy’s centre-right Union pour un Mouvement Populaire (UMP), left the way clear for implementing the new President’s reform agenda over the next five years. This article examines the political context within which Sarkozy was elected to power, the main proposals of his presidential program, the challenges he faces, and his prospects for bringing real change to France.

Abnormal amygdala-prefrontal effective connectivity to happy faces differentiates bipolar from major depression

Background - Bipolar disorder is frequently misdiagnosed as major depressive disorder, delaying appropriate treatment and worsening outcome for many bipolar individuals. Emotion dysregulation is a core feature of bipolar disorder. Measures of dysfunction in neural systems supporting emotion regulation might therefore help discriminate bipolar from major depressive disorder. Methods - Thirty-one depressed individuals—15 bipolar depressed (BD) and 16 major depressed (MDD), DSM-IV diagnostic criteria, ages 18–55 years, matched for age, age of illness onset, illness duration, and depression severity—and 16 age- and gender-matched healthy control subjects performed two event-related paradigms: labeling the emotional intensity of happy and sad faces, respectively. We employed dynamic causal modeling to examine significant among-group alterations in effective connectivity (EC) between right- and left-sided neural regions supporting emotion regulation: amygdala and orbitomedial prefrontal cortex (OMPFC). Results - During classification of happy faces, we found profound and asymmetrical differences in EC between the OMPFC and amygdala. Left-sided differences involved top-down connections and discriminated between depressed and control subjects. Furthermore, greater medication load was associated with an amelioration of this abnormal top-down EC. Conversely, on the right side the abnormality was in bottom-up EC that was specific to bipolar disorder. These effects replicated when we considered only female subjects. Conclusions - Abnormal, left-sided, top-down OMPFC–amygdala and right-sided, bottom-up, amygdala–OMPFC EC during happy labeling distinguish BD and MDD, suggesting different pathophysiological mechanisms associated with the two types of depression.

A multimodal investigation of dynamic face perception using functional magnetic resonance imaging and magnetoencephalography

Motion is an important aspect of face perception that has been largely neglected to date. Many of the established findings are based on studies that use static facial images, which do not reflect the unique temporal dynamics available from seeing a moving face. In the present thesis a set of naturalistic dynamic facial emotional expressions was purposely created and used to investigate the neural structures involved in the perception of dynamic facial expressions of emotion, with both functional Magnetic Resonance Imaging (fMRI) and Magnetoencephalography (MEG). Through fMRI and connectivity analysis, a dynamic face perception network was identified, which is demonstrated to extend the distributed neural system for face perception (Haxby et al.,2000). Measures of effective connectivity between these regions revealed that dynamic facial stimuli were associated with specific increases in connectivity between early visual regions, such as inferior occipital gyri and superior temporal sulci, along with coupling between superior temporal sulci and amygdalae, as well as with inferior frontal gyri. MEG and Synthetic Aperture Magnetometry (SAM) were used to examine the spatiotemporal profile of neurophysiological activity within this dynamic face perception network. SAM analysis revealed a number of regions showing differential activation to dynamic versus static faces in the distributed face network, characterised by decreases in cortical oscillatory power in the beta band, which were spatially coincident with those regions that were previously identified with fMRI. These findings support the presence of a distributed network of cortical regions that mediate the perception of dynamic facial expressions, with the fMRI data providing information on the spatial co-ordinates paralleled by the MEG data, which indicate the temporal dynamics within this network. This integrated multimodal approach offers both excellent spatial and temporal resolution, thereby providing an opportunity to explore dynamic brain activity and connectivity during face processing.

Reference Values For High-density Lipoprotein Particle Size And Volume By Dynamic Light Scattering In A Brazilian Population Sample And Their Relationships With Metabolic Parameters.

Current data indicate that the size of high-density lipoprotein (HDL) may be considered an important marker for cardiovascular disease risk. We established reference values of mean HDL size and volume in an asymptomatic representative Brazilian population sample (n=590) and their associations with metabolic parameters by gender. Size and volume were determined in HDL isolated from plasma by polyethyleneglycol precipitation of apoB-containing lipoproteins and measured using the dynamic light scattering (DLS) technique. Although the gender and age distributions agreed with other studies, the mean HDL size reference value was slightly lower than in some other populations. Both HDL size and volume were influenced by gender and varied according to age. HDL size was associated with age and HDL-C (total population); non- white ethnicity and CETP inversely (females); HDL-C and PLTP mass (males). On the other hand, HDL volume was determined only by HDL-C (total population and in both genders) and by PLTP mass (males). The reference values for mean HDL size and volume using the DLS technique were established in an asymptomatic and representative Brazilian population sample, as well as their related metabolic factors. HDL-C was a major determinant of HDL size and volume, which were differently modulated in females and in males.

Interaction Between Fiscal And Monetary Policy In A Dynamic Nonlinear Model.

The objective of this study is to verify the dynamics between fiscal policy, measured by public debt, and monetary policy, measured by a reaction function of a central bank. Changes in monetary policies due to deviations from their targets always generate fiscal impacts. We examine two policy reaction functions: the first related to inflation targets and the second related to economic growth targets. We find that the condition for stable equilibrium is more restrictive in the first case than in the second. We then apply our simulation model to Brazil and United Kingdom and find that the equilibrium is unstable in the Brazilian case but stable in the UK case.

Key Participants Of The Tumor Microenvironment Of The Prostate: An Approach Of The Structural Dynamic Of Cellular Elements And Extracellular Matrix Components During Epithelial-stromal Transition.

Cancer is a multistep process that begins with the transformation of normal epithelial cells and continues with tumor growth, stromal invasion and metastasis. The remodeling of the peritumoral environment is decisive for the onset of tumor invasiveness. This event is dependent on epithelial-stromal interactions, degradation of extracellular matrix components and reorganization of fibrillar components. Our research group has studied in a new proposed rodent model the participation of cellular and molecular components in the prostate microenvironment that contributes to cancer progression. Our group adopted the gerbil Meriones unguiculatus as an alternative experimental model for prostate cancer study. This model has presented significant responses to hormonal treatments and to development of spontaneous and induced neoplasias. The data obtained indicate reorganization of type I collagen fibers and reticular fibers, synthesis of new components such as tenascin and proteoglycans, degradation of basement membrane components and elastic fibers and increased expression of metalloproteinases. Fibroblasts that border the region, apparently participate in the stromal reaction. The roles of each of these events, as well as some signaling molecules, participants of neoplastic progression and factors that promote genetic reprogramming during epithelial-stromal transition are also discussed.