1000 resultados para Dumas, J.-B.


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Edited by C. Bréghot du Lut.--cf. Advertissement.

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Translated from the French.

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Gilt-stamped cover vignettes; gilt edges.

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Top Row: Barbara A. Fleckenstein, Anne M. Phelan, Julie-Ann Gersin, Laura E. Kemper, Mary Ann McCulloch, Meryl I. Faber, Karen E. Morton, Jennifer S. Miller, Catherine A. Chichester, Dana R. Piper, Harold K. Lohwasser, Michelle A. Lyons, Julia C. Kelly, Deborah L. Rossman, Amy L. Keskey, John F. Nama, Linda Borucki, Michelle M. Bradley, Caroline M. Fischer, Lisa A. Kuhnlein

Row 2: Karen M. Pardo, Laura L. Price, Mollie A. McDonald, Jan M. Grable, Janna S. Nichols, Laura A. Quain, Patricia M. Battel, Claudia J. Koch, Maureen G. D'hondt, Trudy J. Tervo, Linda A. Walz, Cheryl K. Ebling, Patricia A. Merte, Lauri R. Klock, Maria A. Lomibao, Mary E. Eisenhauer, Ellen B. Malvern, Josephine A. Polesnak

Row 3: Yvonne D. Krisel, Rosemary T. Coyne, Janey A. Porterfield, Deborah A. Mulawa, Janet E. Lovelace, Susan P. O'brien, Margaret T. Perrone, Brenda K. Luckhardt, Terry A. Layher, Sharon A. Potonac, Susan K. Watson, Janet A. Servatowski

Row 4: Vivian A. Reeves, Tracey A. Weeks, Marilyn K. Morgan, Terrilynn Phillips, Susan S. Kirk, Robert J. Ziola, Fred Roberts, Karen S. Myron, Pamela M. Przybylski, Mary Jo F. Lafata, Janet A. Scapini, Mary J. Swails

Row 5: Julie E. Reitz, Julie A. Symons, Ave M. Reagor, Catherine A. Regan, Marsha A. Glass, Susan M. Derubeis, Judy L. Goode, Jennifer P. Wylie, Janet L. Nowak, Karen M. Ulfig, Cynthia E. West, Carol A. Czarnecki, Gloria J. Verdi, Lisa D. Singleton

Row 6: Cynthia Wiggins, Monica L. Babyak, Gail M. Ray, Karen S. Desloover, Ladonna L. Christian-Combs, Deborah J. Dunnaback, Deborah A. Cecchini, Nancy A. Neville, Julia H. Grove, Wendy A. Weinfurtner, Susan M. Twigg, Jolynne Vanotteren, Lori A. Clark, Susan T. Savidge

Row 7: Marianne Ojeda, Ann M. Tucker, Lisa A. Valiquette, Sharon J. Bergmann, Elizabeth A. Rice, Marjorie R. Hovis, Laura I. Berry, Janice B. Lindberg, Rhetaugh G. Dumas, Susan B. Steckel, Helen L. Erickson, Kathleen M. Oshea, Tricia A. Richardson, Cheryl L. Sanders, Ann L. Shcoene, Anita M. Bargardi, Constance S. Siler, Anne L. Scott

Row 8: Gassenie Thomas, Victoria L. cadagin, Sheryl A. Strace, Joyce I. Sourbeck, Mary S. Donald, Cindy Tollis, Miriam L. Allis, Julie J. Watson, Patricia A. Shefferly, Nina M. Squire, Carol J. Debrodt, Jennifer A. Dreps, Cynthia B. Stone, Martha A. House, Elizabeth A. Hull, Laurie J. Bommarito, Erin A. Swain, Lisa D. Davis

Row 9: Lisa W. Barak, Charlotte L. Allport, Karen J. Baker, Julie M. Sweet, Pamela R. Armfield, Kathleen A. Hornick, Marcianna M. Davis, Joann L. Holdridge, Barbara A. Black, Scott L. Baker, Lawrene S. Gardipee, Julie A. Hemsteger, Mary Ann Barz, Carla L. Arnett, Danielle L. Bonam, Janice S. Brady, Karen L. Eischer, Amy A. Hing, Marcia L. Hassig, Heidi G. Henn

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Top Row: Douglas G. Pointon, Anne M. Laliberte, Anne T. Reaume, Karen R. Anderson, Margaret A. Mehall, Laura Meintel(Cepko), Sharon M. Milberger, Felicia I. Kle??, Pamela J. DcKeyser, Kathryn G. Maudlin, Mary C. Downey, Julie A. Gergen, Anne K. Hubling, Helen Mourao, Deborah L. Dubrul, Sarah E. Whorf

Row 2: Andrea Mitchell, Karen E. Grost, Paula V. Nersesian, Kelly A. Fleming, Mary Beth Morton, Lynda L. Cooley, Cynthia A. Wandzel, Deborah L. Bach, Karen A. Schwartz, Rhonda G. Pasma, Lesley M. Shafer, Michelle A. Kauer, Mary Jo Raftery, Carol A. Hammell, Josephine G. Ratcliffe

Row 3: Shon A. Pilarski, Julie S. Peritz, Terri L. McPherson, Tina T. chandler, Janet C. Pinkerton, Rosanna M. Knapp, Lisa A. Krukowski, Madelyn L. Nichols, Jaleh Shafii, Elizabeth A. Beer, Molly A. Finn, Dyann E. Botsford, Kathryn J. Meier, Angela L. Bruder (Crane), Herlinda Olive-Downs, Laura B. Bailey

Row 4: Laura L. Brooks, Lisa K. Feezell

Row 5: Cindy L. Harvey, Kerri A. Bacsanyi, Diane R. Cepko, Sheila E. Falk, Marylin A. Jeromin, Marianne Gerard, Sharon L. Podeszwa, Lynette A. LaPratt, Mary Ann Williams, Diana L. Faulk, Christine L. Henriksen, Sharon M. LaMacchia

Row 6: Deborah A. ranazzi (Maxim), Debra J. Mitchell, Holly B. O'Brien, Elaine K. Hebda, Jeanne L. Bruff, Crystal M. Emery, Cleola Hinton, Kathleen T. Hutton, Holly L. Nelson, Karen F. Kraker

Row 7: Meghan A. Sweeney, Christine M. Olree, Marlynn J. Marroso, Toni L. Lowery, Catherine L. Carroll, Elisabeth A. Pennington, Shake Ketefian, Rhetaugh G. Dumas, Janice B. Lindberg, Marlene Rutledge, Kimberley A. Vnuk, Anne M. Walsh, Rae Ann Vander Weide, Cheryl L. Boyd

Row 8: Renee M. Marks, Janine M. Simon, Renee A. Bowles, Linda Kurpinski-Nabozny, Teresa E. Ohman, Joanna E. Bok, Jodi F. Siegel, Janeen M. Chebli, Susan M. Williamson, Mary M. Fedewa, Rose Marie Stacey, Angela J. DeWitt, Kim E. Whelan, Lyndall P. Miller

Row 9: Jean M. Dziurgot, Amy J. Elwart, Lorrie A. Sheck, Amy A. Plasman, Mary L. Schuette, Susan K. Bowen, Heather A. Woodward, Luann N. Richert, Laurie J. Schlukebir, Linda L. Stevenson(Said), Carolyn N. Hartke, Rebecca L. Evans, Kathryn A. Savage, Kathryn A. Sailus (Linden), Heidi Deininger, Jennifer J. Eppley

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Mode of access: Internet.

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Phospholipases A2 (PLA2) are key enzymes for production of lipid mediators. We previously demonstrated that a snake venom sPLA2 named MT-III leads to prostaglandin (PG)E2 biosynthesis in macrophages by inducing the expression of cyclooxygenase-2 (COX-2). Herein, we explored the molecular mechanisms and signaling pathways leading to these MT-III-induced effects. Results demonstrated that MT-III induced activation of the transcription factor NF-κB in isolated macrophages. By using NF-κB selective inhibitors, the involvement of this factor in MT-III-induced COX-2 expression and PGE2 production was demonstrated. Moreover, MT-III-induced COX-2 protein expression and PGE2 release were attenuated by pretreatment of macrophages with SB202190, and Ly294002, and H-7-dihydro compounds, indicating the involvement of p38MAPK, PI3K, and PKC pathways, respectively. Consistent with this, MT-III triggered early phosphorylation of p38MAPK, PI3K, and PKC. Furthermore, SB202190, H-7-dihydro, but not Ly294002 treatment, abrogated activation of NF-κB induced by MT-III. Altogether, these results show for the first time that the induction of COX-2 protein expression and PGE2 release, which occur via NF-κB activation induced by the sPLA2-MT-III in macrophages, are modulated by p38MAPK and PKC, but not by PI3K signaling proteins.

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Staphylococcus aureus aggravates the allergic eosinophilic inflammation. We hypothesized that Staphylococcus aureus-derived enterotoxins directly affect eosinophil functions. Therefore, this study investigated the effects of Staphylococcal enterotoxins A and B (SEA and SEB) on human and mice eosinophil chemotaxis and adhesion in vitro, focusing on p38 MAPK phosphorylation and intracellular Ca(2+) mobilization. Eosinophil chemotaxis was evaluated using a microchemotaxis chamber, whereas adhesion was performed in VCAM-1 and ICAM-1-coated plates. Measurement of p38 MAPK phosphorylation and intracellular Ca(2+) levels were monitored by flow cytometry and fluorogenic calcium-binding dye, respectively. Prior incubation (30 to 240 min) of human blood eosinophils with SEA (0.5 to 3 ng/ml) significantly reduced eotaxin-, PAF- and RANTES-induced chemotaxis (P<0.05). Likewise, SEB (1 ng/ml, 30 min) significantly reduced eotaxin-induced human eosinophil chemotaxis (P<0.05). The reduction of eotaxin-induced human eosinophil chemotaxis by SEA and SEB was prevented by anti-MHC monoclonal antibody (1 μg/ml). In addition, SEA and SEB nearly suppressed the eotaxin-induced human eosinophil adhesion in ICAM-1- and VCAM-1-coated plates. SEA and SEB prevented the increases of p38 MAPK phosphorylation and Ca(2+) levels in eotaxin-activated human eosinophils. In separate protocols, we evaluated the effects of SEA on chemotaxis and adhesion of eosinophils obtained from mice bone marrow. SEA (10 ng/ml) significantly reduced the eotaxin-induced chemotaxis along with cell adhesion to both ICAM-1 and VCAM-1-coated plates (P<0.05). In conclusion, the inhibition by SEA and SEB of eosinophil functions (chemotaxis and adhesion) are associated with reductions of p38 MAPK phosphorylation and intracellular Ca(2+) mobilization.

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Solar radiation, especially ultraviolet A (UVA) and ultraviolet B (UVB), can cause damage to the human body, and exposure to the radiation may vary according to the geographical location, time of year and other factors. The effects of UVA and UVB radiation on organisms range from erythema formation, through tanning and reduced synthesis of macromolecules such as collagen and elastin, to carcinogenic DNA mutations. Some studies suggest that, in addition to the radiation emitted by the sun, artificial sources of radiation, such as commercial lamps, can also generate small amounts of UVA and UVB radiation. Depending on the source intensity and on the distance from the source, this radiation can be harmful to photosensitive individuals. In healthy subjects, the evidence on the danger of this radiation is still far from conclusive.