UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity.

The receptor deleted in colorectal cancer (DCC) directs dynamic polarizing activities in animals toward its extracellular ligand netrin. How DCC polarizes toward netrin is poorly understood. By performing live-cell imaging of the DCC orthologue UNC-40 during anchor cell invasion in Caenorhabditis elegans, we have found that UNC-40 clusters, recruits F-actin effectors, and generates F-actin in the absence of UNC-6 (netrin). Time-lapse analyses revealed that UNC-40 clusters assemble, disassemble, and reform at periodic intervals in different regions of the cell membrane. This oscillatory behavior indicates that UNC-40 clusters through a mechanism involving interlinked positive (formation) and negative (disassembly) feedback. We show that endogenous UNC-6 and ectopically provided UNC-6 orient and stabilize UNC-40 clustering. Furthermore, the UNC-40-binding protein MADD-2 (a TRIM family protein) promotes ligand-independent clustering and robust UNC-40 polarization toward UNC-6. Together, our data suggest that UNC-6 (netrin) directs polarized responses by stabilizing UNC-40 clustering. We propose that ligand-independent UNC-40 clustering provides a robust and adaptable mechanism to polarize toward netrin.

Catalogue des livres qui se trouvent chez la veuve Savoye, libraire, rue S. Jacques, à l'Espérance, à Paris. M. DCC. LXXIII.

[Catalogue de libraire. Paris. Savoye, Veuve d'Étienne-François. 1773]

Catalogue des livres imprimés, ou qui se trouvent en nombre chez Pissot, libraire, quai de Conty, à la descente du Pont-Neuf, à la Sagesse. M. DCC. LIV.

[Catalogue de libraire. Paris. Pissot, Noël-Jacques. 1754]

A taxa ótima de hedge no mercado brasileiro do boi gordo: uma abordagem com BEKK, DCC e BEKK com dummies de safra e entressafra

Esta dissertação tem três objetivos. O primeiro é encontrar o melhor método para se calcular a taxa ótima de “hedge” no mercado brasileiro do boi gordo. Para isso, foram testados cinco modelos: BEKK, DCC de Tse e Tsui (2002), DCC de Engle e Sheppard (2001), BEKK com dummy de safra e BEKK com dummy de entressafra. O segundo é calcular o diferencial de razões de “hedge” entre a safra e entressafra, pois a taxa de “hedge” na entressafra deve ser maior devido a uma maior incerteza sobre um possível choque de oferta, o que afetaria negativamente os custos dos frigoríficos. O terceiro e último objetivo é desvendar o porquê da literatura brasileira de taxa ótima de “hedge” estar encontrando estimativas muito pequenas das taxas quando comparadas às realizadas no mercado. Conclui-se que os modelos DCC’s são os que, no geral, obtém um desempenho melhor pelo critério de redução de variância e aumento do índice de Sharpe e que a taxa de “hedge” na entressafra não deve ser maior que na safra. Nota-se também que a quebra da expectativa intertemporal com a mudança de contratos faz com que a variância da série dos retornos futuros aumente muito, diminuindo assim a taxa de “hedge”.

Villancicos, que se han de cantar en la iglesia parroquial de San Martin Obispo, de ... Valencia, en los ... maytines de su titular en este año M.DCC.LII

Según Palau, XXVII, 367998, fue impreso en 1752

Villancicos que se han de cantar en la parroquial iglesia del Sr. San Martin Obispo de Valencia en los ... maytines de su titular en este año M.DCC.LIII [Texto impreso]

Según Palau, XXVII, 367998, fue impreso en 1753

Villancicos, que se han de cantar en la iglesia parroquial de San Martin Obispo, de ... Valencia en los ... maytines de su titular en este año M.DCC.LI [Texto impreso]

Fecha tomada de 1751 tomada del tít

Villancicos que se han de cantar en la iglesia parroquial de San Martin Obispo de ... Valencia, en los ... maytines de su titular en este año M.DCC.LIV [Texto impreso]

Según Palau, XXVII, 367999, fue impreso en 1754

The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation

The expression of DCC (deleted in colorectal cancer) is often markedly reduced in colorectal and other cancers. However, the rarity of point mutations identified in DCC coding sequences and the lack of a tumor predisposition phenotype in DCC hemizygous mice have raised questions about its role as a tumor suppressor. DCC also mediates axon guidance and functions as a dependence receptor; such receptors create cellular states of dependence on their respective ligands by inducing apoptosis when unoccupied by ligand. We now show that DCC drives cell death independently of both the mitochondria-dependent pathway and the death receptor/caspase-8 pathway. Moreover, we demonstrate that DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 without a requirement for cytochrome c or Apaf-1. Hence, DCC defines an additional pathway for the apoptosome-independent caspase activation.

Kalendario manual y guia de forasteros en Madrid para el año de M. DCC. LXIX ...

Estado militar de España, año de 1769, con port. propia.

Discours prononcés dans l'Académie françoise, le Jeudi XVI Février M.DCC.LXXV a la réception de M. de Lamoignon de Malesherbes.

Mode of access: Internet.

Histoire de l'Academie Royale des Sciences : année M.DCC. avec les mémoires de mathématiques & de physique, pour la même année, tirés des registres de cette Académie.

Mode of access: Internet.