941 resultados para Davis, William
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When T cells become infected by the parasite Theileria parva, they acquire a transformed phenotype and no longer require antigen-specific stimulation or exogenous growth factors. This is accompanied by constitutive interleukin 2 (IL-2) and IL-2 receptor expression. Transformation can be reversed entirely by elimination of the parasites using the specific drug BW720c. Extracellular signal-regulated kinase and jun NH2-terminal kinase (JNK) are members of the mitogen-activated protein kinase family, which play a central role in the regulation of cellular differentiation and proliferation and also participate in the regulation of IL-2 and IL-2 receptor gene expression. T. parva was found to induce an unorthodox pattern of mitogen-activated protein kinase expression in infected T cells. JNK-1 and JNK-2 are constitutively active in a parasite-dependent manner, but have altered properties. In contrast, extracellular signal-regulated kinase-2 is not activated even though its activation pathway is functionally intact. Different components of the T cell receptor (TCR)-dependent signal transduction pathways also were examined. The TCRζ or CD3ɛ chains were found not to be phosphorylated and T. parva-transformed T cells were resistant to inhibitors that block the early steps of T cell activation. Compounds that inhibit the progression of T cells to proliferation, however, were inhibitory. Our data provide the first example, to our knowledge, for parasite-mediated JNK activation, and our findings strongly suggest that T. parva not only lifts the requirement for antigenic stimulation but also entirely bypasses early TCR-dependent signal transduction pathways to induce continuous proliferation.
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Contains entries regarding accounts describing a wide variety of legal services and fees performed for individuals and especially for several towns (Dartmouth, Taunton, New Bedford, and Mashpee). These services include probating wills, drawing wills, prosecutions, depositions, warrants, writs, and bankruptcy.
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Account of cash paid out to various people.
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Mode of access: Internet.
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"Prepared under the direction of Dr. William H. Davis, chief statistician for vital statistics, and under the immediate supervision of Richard C. Lappin, expert special agent of the Bureau of the Census.--Letter of transmittal, p. 5.
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Mode of access: Internet.
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Mode of access: Internet.
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Mode of access: Internet.
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Reproduced from Studies in history, economics, and public law, vol. 53, whole no. 131.
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Mode of access: Internet.
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Includes bibliographical references.
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Mode of access: Internet.
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Mode of access: Internet.