Käyttöliittymä verkonhallintaan sulautetussa Linux-käyttöjärjestelmässä

During the project we get familiar with Linksys WRT54GL wireless router and its network managing methods. Operating system is OpenWRT which is Linux-based distribution for embedded devices. OpenWRT uses two kind of approach for its network administration. The first one is web-based user interface and the second one is command line based. Both methods are working but do not solve all problems that competent network administrator can need for secured network managing. The goal of the project was design an NCurses-based user interface for network administration that can be run from command line. The user interface can be use for example from terminal via SSH which is yet faster and also light to use. The idea is to combine the user friendly of WWW-interface and the advanced options that command line based network managing can offer. Linux-based open source OpenWRT offers good development tools. There exist also a compact development community if there is need for further development of software in future. So far user interface for command line based network administrator is not available.

RTOG 0525: Exploratory Subset Analysis from a Randomized Phase III Trial Comparing Standard (std) Adjuvant Temozolomide (TMZ) with a Dose-dense (dd) Schedule for Glioblastoma (GBM)

Purpose/Objective(s): RTwith TMZ is the standard for GBM. dd TMZ causes prolongedMGMTdepletion in mononuclear cells and possibly in tumor. The RTOG 0525 trial (ASCO 2011) did not show an advantage from dd TMZ for survival or progression free survival. We conducted exploratory, hypothesis-generating subset analyses to detect possible benefit from dd TMZ.Materials/Methods: Patients were randomized to std (150-200 mg/m2 x 5 d) or dd TMZ (75-100 mg/m2 x 21 d) q 4 weeks for 6- 12 cycles. Eligibility included age.18, KPS$ 60, and. 1 cm2 tissue for prospective MGMTanalysis for stratification. Furtheranalyses were performed for all randomized patients (''intent-to-treat'', ITT), and for all patients starting protocol therapy (SPT). Subset analyses were performed by RPA class (III, IV, V), KPS (90-100, = 50,\50), resection (partial, total), gender (female, male), and neurologic dysfunction (nf = none, minor, moderate).Results: No significant difference was seen for median OS (16.6 vs. 14.9 months), or PFS (5.5 vs. 6.7 months, p = 0.06). MGMT methylation was linked to improved OS (21.2 vs. 14 months, p\0.0001), and PFS (8.7 vs. 5.7 months, p\0.0001). For the ITT (n = 833), there was no OS benefit from dd TMZ in any subset. Two subsets showed a PFS benefit for dd TMZ: RPA class III (6.2 vs. 12.6 months, HR 0.69, p = 0.03) and nf = minor (HR 0.77, p = 0.01). For RPA III, dd dramatically delayed progression, but post-progression dd patients died more quickly than std. A similar pattern for nf = minor was observed. For the SPT group (n = 714) there was neither PFS nor OS benefit for dd TMZ, overall. For RPA class III and nf = minor, there was a PFS benefit for dd TMZ (HR 0.73, p = 0.08; HR 0.77, p = 0.02). For nf = moderate subset, both ITT and SPT, the std arm showed superior OS (14.4 vs. 10.9 months) compared to dd, without improved PFS (HR 1.46, p = 0.03; and HR 1.74, p = 0.01. In terms of methylation status within this subset, there were more methylated patients in the std arm of the ITT subset (n = 159; 32 vs. 24%). For the SPT subset (n = 124), methylation status was similar between arms.Conclusions: This study did not demonstrate improved OS for dd TMZ for any subgroup, but for 2 highly functional subgroups, PFS was significantly increased. These data generate the testable hypothesis that intensive treatment may selectively improve disease control in those most likely able to tolerate dd therapy. Interpretation of this should be considered carefully due to small sample size, the process of multiple observations, and other confounders.Acknowledgment: This project was supported by RTOG grant U10 CA21661, and CCOP grant U10 CA37422 from the National Cancer Institute (NCI).

Origenis Opera omnia ex variis editionibus et codicibus manu exaratis gallicanis, italicis, germanicis et anglicis collecta : atque adnotationibus illustrata, cum copiosis indicibus, vita auctoris et multis dissertationibus. T1 / opera et studio DD. Caroli et Caroli Vincentii Delarue... ; accurante J.-P. Migne...

Collection : Patrologiae cursus completus ; 8-10

Origenis Opera omnia ex variis editionibus et codicibus manu exaratis gallicanis, italicis, germanicis et anglicis collecta : atque adnotationibus illustrata, cum copiosis indicibus, vita auctoris et multis dissertationibus. T3 / opera et studio DD. Caroli et Caroli Vincentii Delarue... ; accurante J.-P. Migne...

Collection : Patrologiae cursus completus ; 8-10

Origenis Opera omnia ex variis editionibus et codicibus manu exaratis gallicanis, italicis, germanicis et anglicis collecta : atque adnotationibus illustrata, cum copiosis indicibus, vita auctoris et multis dissertationibus. T2 / opera et studio DD. Caroli et Caroli Vincentii Delarue... ; accurante J.-P. Migne...

Collection : Patrologiae cursus completus ; 8-10

Origenis Opera omnia ex variis editionibus et codicibus manu exaratis gallicanis, italicis, germanicis et anglicis collecta : atque adnotationibus illustrata, cum copiosis indicibus, vita auctoris et multis dissertationibus. T4 / opera et studio DD. Caroli et Caroli Vincentii Delarue... ; accurante J.-P. Migne...

Collection : Patrologiae cursus completus ; 8-10

Registro de incidencias : seguridad en ficheros automatizados. Protección de datos de carácter personal (DD.CC.PP.)

El proyecto de Registro Automatizado de Incidencias tiene como objeto el desarrollo de un software que permita realizar el procedimiento de notificación, gestión y respuesta ante las incidencias. Se considerarán como "incidencias de seguridad", entre otras, cualquier incumplimiento de la normativa desarrollada en el Documento de Seguridad, así como a cualquier anomalía que afecte o pueda afectar a la seguridad de los datos de carácter personal.

RTOG 0525: A randomized phase iii trial comparing standard adjuvant temozolomide (tmz) with a dose-dense (dd) schedule in newly diagnosed glioblastoma (gbm)

Radiotherapy with concomitant and adjuvant TMZ is the standard of care for newly diagnosed GBM. MGMT methylation status may be an important determinant of treatment response. This trial, conducted by the RTOG, EORTC, and NCCTG, determined if intensified TMZ improves survival (OS) or progression free survival (PFS) in all patients or specific to MGMT status. Eligibility criteria included age . 18 yrs, KPS ≥ 60, and existence of a tissue block with . 1cm2 tumor for prospective MGMT and retrospective molecular analysis. Patients were randomized to Arm 1: standard TMZ (150-200 mg/m2 x 5 d) or Arm 2: dd TMZ (75-100 mg/m2 x 21 d) q 4 wks for 6-12 cycles. Symptom burden, quality of life (QOL), and neurocognition were prospectively and longitudinally assessed in a patient subset. 833 patients were randomized (1173 registered). Inadequate tissue (n ¼ 144) was the most frequent reason for nonrandomization.No statistical difference was observed between Arms 1 and 2 for median OS (16.6, 14.9 mo, p ¼ 0.63), median PFS (5.5, 6.7 mo, p ¼ 0.06), or methylation status. MGMT methylation was associated with improved OS (21.2, 14 mo, p , 0.0001), PFS (8.7, 5.7 mo, p , 0.0001), and treatment response (p ¼ 0.012). Cox modeling identifiedMGMT status and RPA class as significant predictors of OS; treatment arm and radiation technique (EORTC vs. RTOG) were not. There was increased grade ≥ 3 toxicity in Arm 2 (19%, 27%, p ¼ 0.008), which was mostly lymphopenia and fatigue. This study did not demonstrate improved efficacy for dd TMZ for newly diagnosed GBM regardless of methylation status. However, it confirmed the prognostic significance of MGMT methylation in GBM, demonstrated the feasibility of tumor tissue collection, molecular stratification, and collection of patient outcomes in a large transatlantic intergroup trial, thereby establishing a viable clinical trial paradigm. Support: NCI U10 CA 21661 and U10 CA37422.

Development and validation of the Family Vulnerability Index to Disability and Dependence (FVI-DD)

This exploratory, descriptive, cross-sectional, and quantitative study aimed to develop and validate an index of family vulnerability to disability and dependence (FVI-DD). This study was adapted from the Family Development Index, with the addition of social and health indicators of disability and dependence. The instrument was applied to 248 families in the city of Sao Paulo, followed by exploratory factor analysis. Factor validation was performed using the concurrent and discriminant validity of the Lawton scale and Katz Index. The descriptive level adopted for the study was p < 0.05. The final vulnerability index comprised 50 questions classified into seven factors contemplating social and health dimensions, and this index exhibited good internal consistency (Cronbach’s alpha = 0.82). FVI-DD was validated using both the Lawton scale and Katz Index. We conclude that FVI-DD can accurately and reliably assess family vulnerability to disability and dependence.

Wårt land - [Pärmen]

Helsingfors : F. Tengström 1848

Philipp Melanchthon i backspegeln : 450 år efter hans död

Kirjallisuusarvostelu