DCC plays a role in navigation of forebrain axons across the ventral midbrain commissure in embryonic Xenopus

In the developing vertebrate brain, growing axons establish a scaffold of axon tracts connected across the midline via commissures. We have previously identified a population of telencephalic neurons that express NOC-2, a novel glycoform of the neural cell adhesion molecule N-CAM that is involved in axon guidance in the forebrain. These axons arise from the presumptive telencephalic nucleus, course caudally along the principal longitudinal tract of the forebrain, cross the ventral midline in the midbrain, and then project to the contralateral side of the brain. In the present study we have investigated mechanisms controlling the growth of these axons across the ventral midline of the midbrain. The axon guidance receptor DCC is expressed by the NOC-2 population of axons both within the longitudinal tract and within the ventral midbrain commissure. Disruption of DCC-dependent interactions, both in vitro and in vivo, inhibited the NOC-2 axons from crossing the ventral midbrain. Instead, these axons grew along aberrant trajectories away from the midline, suggesting that DCC-dependent interactions are important for overcoming inhibitory mechanisms within the midbrain of the embryonic vertebrate brain. Thus, coordinated responsiveness of forebrain axons to both chemostimulatory and chemorepulsive cues appears to determine whether they cross the ventral midline in the midbrain, (C) 2000 Academic Press.

Official Central Bank Interventions in the Foreign Exchange Markets: A DCC Approach with Exogenous Variables

This paper assesses the impact of official central bank interventions (CBIs) on exchange rate returns, their volatility and bilateral correlations. By exploiting the recent publication of intervention data by the Bank of England, this study is able to investigate fficial interventions by a total number of four central banks, while the previous studies have been limited to three (the Federal Reserve, Bundesbank and Bank of Japan). The results of the existing literature are reappraised and refined. In particular, unilateral CBI is found to be more successful than coordinated CBI. The likely implications of these findings are then discussed.

Catalogue des livres qui se trouvent chez la veuve Savoye, libraire, rue S. Jacques, à l'Espérance, à Paris. M. DCC. LXXIII.

[Catalogue de libraire. Paris. Savoye, Veuve d'Étienne-François. 1773]

Catalogue des livres imprimés, ou qui se trouvent en nombre chez Pissot, libraire, quai de Conty, à la descente du Pont-Neuf, à la Sagesse. M. DCC. LIV.

[Catalogue de libraire. Paris. Pissot, Noël-Jacques. 1754]

A taxa ótima de hedge no mercado brasileiro do boi gordo: uma abordagem com BEKK, DCC e BEKK com dummies de safra e entressafra

Esta dissertação tem três objetivos. O primeiro é encontrar o melhor método para se calcular a taxa ótima de “hedge” no mercado brasileiro do boi gordo. Para isso, foram testados cinco modelos: BEKK, DCC de Tse e Tsui (2002), DCC de Engle e Sheppard (2001), BEKK com dummy de safra e BEKK com dummy de entressafra. O segundo é calcular o diferencial de razões de “hedge” entre a safra e entressafra, pois a taxa de “hedge” na entressafra deve ser maior devido a uma maior incerteza sobre um possível choque de oferta, o que afetaria negativamente os custos dos frigoríficos. O terceiro e último objetivo é desvendar o porquê da literatura brasileira de taxa ótima de “hedge” estar encontrando estimativas muito pequenas das taxas quando comparadas às realizadas no mercado. Conclui-se que os modelos DCC’s são os que, no geral, obtém um desempenho melhor pelo critério de redução de variância e aumento do índice de Sharpe e que a taxa de “hedge” na entressafra não deve ser maior que na safra. Nota-se também que a quebra da expectativa intertemporal com a mudança de contratos faz com que a variância da série dos retornos futuros aumente muito, diminuindo assim a taxa de “hedge”.

Villancicos, que se han de cantar en la iglesia parroquial de San Martin Obispo, de ... Valencia, en los ... maytines de su titular en este año M.DCC.LII

Según Palau, XXVII, 367998, fue impreso en 1752

Villancicos que se han de cantar en la parroquial iglesia del Sr. San Martin Obispo de Valencia en los ... maytines de su titular en este año M.DCC.LIII [Texto impreso]

Según Palau, XXVII, 367998, fue impreso en 1753

Villancicos, que se han de cantar en la iglesia parroquial de San Martin Obispo, de ... Valencia en los ... maytines de su titular en este año M.DCC.LI [Texto impreso]

Fecha tomada de 1751 tomada del tít

Villancicos que se han de cantar en la iglesia parroquial de San Martin Obispo de ... Valencia, en los ... maytines de su titular en este año M.DCC.LIV [Texto impreso]

Según Palau, XXVII, 367999, fue impreso en 1754

The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation

The expression of DCC (deleted in colorectal cancer) is often markedly reduced in colorectal and other cancers. However, the rarity of point mutations identified in DCC coding sequences and the lack of a tumor predisposition phenotype in DCC hemizygous mice have raised questions about its role as a tumor suppressor. DCC also mediates axon guidance and functions as a dependence receptor; such receptors create cellular states of dependence on their respective ligands by inducing apoptosis when unoccupied by ligand. We now show that DCC drives cell death independently of both the mitochondria-dependent pathway and the death receptor/caspase-8 pathway. Moreover, we demonstrate that DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9 without a requirement for cytochrome c or Apaf-1. Hence, DCC defines an additional pathway for the apoptosome-independent caspase activation.

Kalendario manual y guia de forasteros en Madrid para el año de M. DCC. LXIX ...

Estado militar de España, año de 1769, con port. propia.