962 resultados para Cyrus, King of Persia, -529 B.C.
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Mode of access: Internet.
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Mode of access: Internet.
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The work of a group of English writers each letter being signed by an initial indicating the author, as follows. P.-Philip Yorke; C.-Charles Yorke; R.-G.H. Rooke; G.-John Green; W.-Daniel Wray; H.-Henry Heaton; E.-Wm. Heberden; O.-Henry Coventry; L.-John Lawry; T.-Catherine Talbot; B.-Thomas Birch; S.-Samuel Salter. The work was edited by Thomas Birch, the brothers Yorke having the largest share in the composition of the letters.
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Greek and English on opposite pages.
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Senior thesis written for Oceanography 445
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Human c-sis/PDGF-B proto-oncogene has been shown to be overexpressed in a large percentage of human tumor cells establishing a growth-promoting, autocrine growth circuit. Triplex forming oligonucleotides (TFOs) can recognize and bind sequences in duplex DNA, and have received considerable attention because of their potential for targeting specific genomic sites. The c-sis/PDGF-B promoter contains a unique homopurine/homopyrimidine sequence (SIS proximal element, SPE), which is crucial for binding nuclear factors that provoke transcription. In order to develop specific transcriptional inhibitors of the human c-sis/PDGF-B proto-oncogene, 20 potential TFOs targeting part or all of the SPE were screened by gel mobility analysis. DNase I footprinting shows that the TFOs we designed can form a sequence-specific triplex with the target. Protein binding assays demonstrate that triplex formation inhibits nuclear factors binding the c-sis/PDGF-B promoter. Both transient and stable transfection experiments demonstrate that the transcriptional activity of the promoter is considerably inhibited by the TFOs. We propose that TFOs represent a therapeutic potential to specifically diminish the expression of c-sis/PDGF-B proto-oncogene in various pathologic settings where constitutive expression of this gene has been observed.
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"List of authorities": v. 1, p. 540-553.
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Includes biographical references and index.
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Includes index.
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Mode of access: Internet.
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Includes bibliographical references.
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Mode of access: Internet.
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Sabin 58729; Wagner 70.
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Mode of access: Internet.
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Scripta minora consists of: Oeconomici, Conivii, Hieronis, Agesilai, Reipubicae Lacedaemoniorum, Reipublicae Atheniensium, De vectigalibus libri, Hipparchici, De re equestri libri, Cynegetici, and Apologiae Socratis.