1000 resultados para Curricular domain
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As características da atualidade exigem que se seja criativo e inovador. Todo o indivíduo pode rentabilizar intencionalmente seu potencial criativo, podendo e devendo a universidade ter um papel importante nesse desenvolvimento. Porém, observam-se perceções de barreiras à expressão criativa em alunos universitários, apesar de existir muito pouca investigação acerca do tema. Neste estudo, quis-se então analisar perceções de barreiras à criatividade em estudantes universitários portugueses, tomando 582 alunos de três áreas curriculares (Artes e Humanidades; Ciências e Tecnologias; Ciências Sociais e Humanas) e dois níveis de graduação (licenciatura e mestrado). Usou-se o Inventário de Barreiras Pessoais à Expressão Criativa, adaptado à realidade portuguesa. Foram avaliadas diferenças, considerando os fatores do inventário, mas também os seus itens numa análise mais detalhada. Encontraram-se diferenciações nos fatores para a área curricular e, no caso dos itens, para as duas variáveis estudadas. Algumas reflexões são feitas no sentido de repensar práticas no quotidiano académico.
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En este artículo se aborda la primera versión de la Educación Sexual Integral para la ciudad de Buenos Aires. El objetivo es analizar los mecanismos discursivos y de poder que se han puesto en juego en su delimitación como un dominio curricular específico. Concretamente, se analiza el modo en que el cuerpo y la sexualidad infantil y femenina fueron especificados como objetos de saber y de intervención en los documentos curriculares editados en 2007 por el Gobierno de la Ciudad de Buenos Aires a partir de la sanción de la Ley de Educación Sexual Integral. Se señalan los criterios normalizantes a partir de los que se delimitó la inteligibilidad, por un lado, del cuerpo y la sexualidad infantil como un dominio de pureza, inocencia e incompletitud. Y, por el otro lado, del cuerpo y la sexualidad femenina como dominio biologizado y sujeto a un destino reproductivo y heterosexual.
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En este artículo se aborda la primera versión de la Educación Sexual Integral para la ciudad de Buenos Aires. El objetivo es analizar los mecanismos discursivos y de poder que se han puesto en juego en su delimitación como un dominio curricular específico. Concretamente, se analiza el modo en que el cuerpo y la sexualidad infantil y femenina fueron especificados como objetos de saber y de intervención en los documentos curriculares editados en 2007 por el Gobierno de la Ciudad de Buenos Aires a partir de la sanción de la Ley de Educación Sexual Integral. Se señalan los criterios normalizantes a partir de los que se delimitó la inteligibilidad, por un lado, del cuerpo y la sexualidad infantil como un dominio de pureza, inocencia e incompletitud. Y, por el otro lado, del cuerpo y la sexualidad femenina como dominio biologizado y sujeto a un destino reproductivo y heterosexual.
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En este artículo se aborda la primera versión de la Educación Sexual Integral para la ciudad de Buenos Aires. El objetivo es analizar los mecanismos discursivos y de poder que se han puesto en juego en su delimitación como un dominio curricular específico. Concretamente, se analiza el modo en que el cuerpo y la sexualidad infantil y femenina fueron especificados como objetos de saber y de intervención en los documentos curriculares editados en 2007 por el Gobierno de la Ciudad de Buenos Aires a partir de la sanción de la Ley de Educación Sexual Integral. Se señalan los criterios normalizantes a partir de los que se delimitó la inteligibilidad, por un lado, del cuerpo y la sexualidad infantil como un dominio de pureza, inocencia e incompletitud. Y, por el otro lado, del cuerpo y la sexualidad femenina como dominio biologizado y sujeto a un destino reproductivo y heterosexual.
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O objetivo deste trabalho é responder as perguntas: o que é museologia, o que a diferencia dos outros saberes, isto é, quais são os seus estatutos epistemológicos, porque a Museologia assume no Brasil aspecto predominantemente técnico o que afasta, quase sempre seus profissionais dos postos de comando e/ou decisão na área que lhe é afeta. O tema educacional está imbricado na problemática epistemológica. O tema é abordado através de diferentes aspectos e sucessivas visões: - como o Curso de Museus se inseriu no contexto histórico que lhe deu origem, a longa proposta ideológica do então único Curso de Museus do país, o desempenho deste mesmo curso de sua fundação até os dias de hoje, duas divisões de seus currículos uma quanto a sua coerência ou não com cada momento educacional e outra quanto aos conteúdos. O museu sua gênese e desempenho mundial até hoje. Estas primeiras aproximações nos levaram a constatar faltar à Museologia a evidenciação de seus estatutos epistemológicos, princípios e categorias, que a mostrasse como um saber diferenciado. Aquelas múltiplas visões nos permitiram chegar aos conceitos adequados, na área, para nosso trabalho. Passamos a ordenar o assunto por campos e destes extraímos princípios museológicos e reconhecemos estes como relacionados com a Antropologia Filosófica. Levantamos as Categorias de Antropologia Filosófica contidas nas obras de Jolif e conectamos aqueles "Princípios Museológicos" com estas categorias. Passamos, assim, a ter uma correlação Museologia/ Antropologia Filosófica que ~ permite a Museologia desenvolver-se estruturadamente passando a ter "background" para sustentar uma proposta de ensino universitário e de formação superior para o profissional de museologia e para consequentemente sustentar a pesquisa, a reflexão e a decisão nas lides e no desenvolvi menta contínuo do saber diferenciado: Museologia.
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"This study has centered around an evaluation of the function of the course in General botany in preparing students for the pursual of sequent courses in the College of Agriculture and Forestry."--p. [134]
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Mode of access: Internet.
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This study aimed to identify novel biomarkers for thyroid carcinoma diagnosis and prognosis. We have constructed a human single-chain variable fragment (scFv) antibody library that was selected against tumour thyroid cells using the BRASIL method (biopanning and rapid analysis of selective interactive ligands) and phage display technology. One highly reactive clone, scFv-C1, with specific binding to papillary thyroid tumour proteins was confirmed by ELISA, which was further tested against a tissue microarray that comprised of 229 thyroid tissues, including: 110 carcinomas (38 papillary thyroid carcinomas (PTCs), 42 follicular carcinomas, 30 follicular variants of PTC), 18 normal thyroid tissues, 49 nodular goitres (NG) and 52 follicular adenomas. The scFv-C1 was able to distinguish carcinomas from benign lesions (P=0.0001) and reacted preferentially against T1 and T2 tumour stages (P=0.0108). We have further identified an OTU domain-containing protein 1, DUBA-7 deubiquitinating enzyme as the scFv-binding antigen using two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. The strategy of screening and identifying a cell-surface-binding antibody against thyroid tissues was highly effective and resulted in a useful biomarker that recognises malignancy among thyroid nodules and may help identify lower-risk cases that can benefit from less-aggressive management.
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The goal of this cross-sectional observational study was to quantify the pattern-shift visual evoked potentials (VEP) and the thickness as well as the volume of retinal layers using optical coherence tomography (OCT) across a cohort of Parkinson's disease (PD) patients and age-matched controls. Forty-three PD patients and 38 controls were enrolled. All participants underwent a detailed neurological and ophthalmologic evaluation. Idiopathic PD cases were included. Cases with glaucoma or increased intra-ocular pressure were excluded. Patients were assessed by VEP and high-resolution Fourier-domain OCT, which quantified the inner and outer thicknesses of the retinal layers. VEP latencies and the thicknesses of the retinal layers were the main outcome measures. The mean age, with standard deviation (SD), of the PD patients and controls were 63.1 (7.5) and 62.4 (7.2) years, respectively. The patients were predominantly in the initial Hoehn-Yahr (HY) disease stages (34.8% in stage 1 or 1.5, and 55.8 % in stage 2). The VEP latencies and the thicknesses as well as the volumes of the retinal inner and outer layers of the groups were similar. A negative correlation between the retinal thickness and the age was noted in both groups. The thickness of the retinal nerve fibre layer (RNFL) was 102.7 μm in PD patients vs. 104.2 μm in controls. The thicknesses of retinal layers, VEP, and RNFL of PD patients were similar to those of the controls. Despite the use of a representative cohort of PD patients and high-resolution OCT in this study, further studies are required to establish the validity of using OCT and VEP measurements as the anatomic and functional biomarkers for the evaluation of retinal and visual pathways in PD patients.
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Purpose. To investigate misalignments (MAs) on retinal nerve fiber layer thickness (RNFLT) measurements obtained with Cirrus(©) SD-OCT. Methods. This was a retrospective, observational, cross-sectional study. Twenty-seven healthy and 29 glaucomatous eyes of 56 individuals with one normal exam and another showing MA were included. MAs were defined as an improper alignment of vertical vessels in the en face image. MAs were classified in complete MA (CMA) and partial MA (PMA), according to their site: 1 (superior, outside the measurement ring (MR)), 2 (superior, within MR), 3 (inferior, within MR), and 4 (inferior, outside MR). We compared RNFLT measurements of aligned versus misaligned exams in all 4 sectors, in the superior area (sectors 1 + 2), inferior area (sectors 3 + 4), and within the measurement ring (sectors 2 + 3). Results. RNFLT measurements at 12 clock-hour of eyes with MAs in the superior area (sectors 1 + 2) were significantly lower than those obtained in the same eyes without MAs (P = 0.043). No significant difference was found in other areas (sectors 1 + 2 + 3 + 4, sectors 3 + 4, and sectors 2 + 3). Conclusion. SD-OCT scans with superior MAs may present lower superior RNFLT measurements compared to aligned exams.
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The human mitochondrial Hsp70, also called mortalin, is of considerable importance for mitochondria biogenesis and the correct functioning of the cell machinery. In the mitochondrial matrix, mortalin acts in the importing and folding process of nucleus-encoded proteins. The in vivo deregulation of mortalin expression and/or function has been correlated with age-related diseases and certain cancers due to its interaction with the p53 protein. In spite of its critical biological roles, structural and functional studies on mortalin are limited by its insoluble recombinant production. This study provides the first report of the production of folded and soluble recombinant mortalin when co-expressed with the human Hsp70-escort protein 1, but it is still likely prone to self-association. The monomeric fraction of mortalin presented a slightly elongated shape and basal ATPase activity that is higher than that of its cytoplasmic counterpart Hsp70-1A, suggesting that it was obtained in the functional state. Through small angle X-ray scattering, we assessed the low-resolution structural model of monomeric mortalin that is characterized by an elongated shape. This model adequately accommodated high resolution structures of Hsp70 domains indicating its quality. We also observed that mortalin interacts with adenosine nucleotides with high affinity. Thermally induced unfolding experiments indicated that mortalin is formed by at least two domains and that the transition is sensitive to the presence of adenosine nucleotides and that this process is dependent on the presence of Mg2+ ions. Interestingly, the thermal-induced unfolding assays of mortalin suggested the presence of an aggregation/association event, which was not observed for human Hsp70-1A, and this finding may explain its natural tendency for in vivo aggregation. Our study may contribute to the structural understanding of mortalin as well as to contribute for its recombinant production for antitumor compound screenings.
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PURPOSE: To evaluate the sensitivity and specificity of machine learning classifiers (MLCs) for glaucoma diagnosis using Spectral Domain OCT (SD-OCT) and standard automated perimetry (SAP). METHODS: Observational cross-sectional study. Sixty two glaucoma patients and 48 healthy individuals were included. All patients underwent a complete ophthalmologic examination, achromatic standard automated perimetry (SAP) and retinal nerve fiber layer (RNFL) imaging with SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec Inc., Dublin, California). Receiver operating characteristic (ROC) curves were obtained for all SD-OCT parameters and global indices of SAP. Subsequently, the following MLCs were tested using parameters from the SD-OCT and SAP: Bagging (BAG), Naive-Bayes (NB), Multilayer Perceptron (MLP), Radial Basis Function (RBF), Random Forest (RAN), Ensemble Selection (ENS), Classification Tree (CTREE), Ada Boost M1(ADA),Support Vector Machine Linear (SVML) and Support Vector Machine Gaussian (SVMG). Areas under the receiver operating characteristic curves (aROC) obtained for isolated SAP and OCT parameters were compared with MLCs using OCT+SAP data. RESULTS: Combining OCT and SAP data, MLCs' aROCs varied from 0.777(CTREE) to 0.946 (RAN).The best OCT+SAP aROC obtained with RAN (0.946) was significantly larger the best single OCT parameter (p<0.05), but was not significantly different from the aROC obtained with the best single SAP parameter (p=0.19). CONCLUSION: Machine learning classifiers trained on OCT and SAP data can successfully discriminate between healthy and glaucomatous eyes. The combination of OCT and SAP measurements improved the diagnostic accuracy compared with OCT data alone.
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Universidade Estadual de Campinas . Faculdade de Educação Física
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Universidade Estadual de Campinas. Faculdade de Educação Física
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Universidade Estadual de Campinas. Faculdade de Educação Física