Memoir and correspondence of Mrs. Mary Ann Odiorne Clark,

Mode of access: Internet.

Mary Ann Wilson, Hüftbild

Signatur des Originals: S 36/G02530

To Mary Ann [passages copied from several poems, written by an unknown student on November 21, 1790]

The creator of this document is unknown, though he was presumably a student at Harvard College, as the name of the college appears on the document twice. Both sides of the document are filled with passages of poetry, including one from Tobias George Smollett's "The Adventures of Roderick Random" and another from John Tapner's "A New Collection of Fables in Verse." The creator seems to have intended the document for someone named Mary Ann.

Memoir of Mary Ann Gilpin of Bristol : consisting chiefly of extracts from her diary and letters.

Joseph Smith states in his Catalogue of Friends' books that Charles Gilpin edited this work.

The triumph of virtue : the trial of Miss Mary Ann Tocker, who plead her own cause, for an alleged libel on R. Gurney, Jun. ... to which is prefixed a letter to Miss Tocker, and to which is added an address to jury-men on their duties as jurors, and especially on trials for criminal libel /

"From the third New-York edition."

Bella Abzug and Mary Ann Krupsak at Women's March in Battery Park

General note: Title and date provided by Bettye Lane.

Genome - wide association study identifies novel breast cancer susceptibility loci

Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic variance is likely to be due to variants conferring more moderate risks. To identify further susceptibility alleles, we conducted a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls, followed by a third stage in which 30 single nucleotide polymorphisms (SNPs) were tested for confirmation in 21,860 cases and 22,578 controls from 22 studies. We used 227,876 SNPs that were estimated to correlate with 77% of known common SNPs in Europeans at r² > 0.5. SNPs in five novel independent loci exhibited strong and consistent evidence of association with breast cancer (P < 10^-7). Four of these contain plausible causative genes (FGFR2, TNRC9, MAP3K1 and LSP1). At the second stage, 1,792 SNPs were significant at the P < 0.05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach.

Characterization of zebrafish polymerase iii promoters for the expression of short hairpin RNA interference molecules

RNA interference (RNAi) is a powerful, sequence specific, and long-lasting method of gene knockdown, and can be elicited by the expression of short-hairpin RNA (shRNA) molecules driven via polymerase III type 3 promoters from a DNA vector or transgene. To further develop RNAi as a tool in zebrafish, we have characterized the zebrafish U6 and H1 snRNA promoters and compared the efficiency of each of the promoters to express an shRNA and silence a reporter gene, relative to previously characterized U6 promoters from pufferfish, chicken, and mouse. Our results show that the zebrafish polymerase III promoters were capable of effective gene silencing in the zebrafish ZF4 cell line, but were ineffective in mammalian Vero cells. In contrast, mouse and chicken promoters were active in Vero but not ZF4 cells, highlighting the importance of homologous promoters to achieve effective silencing.