Jorge H. Evans Civit (ed.), Antología del Index Aristotelicus de H. Bonitz, Buenos Aires, Santiago Arcos, 2010. Colaboradores del área de Lenguas Clásicas: L. Sardi de Estrella, E. Driban, E. Cecco, M.E. Guevara de Álvarez, C. Silventi, M.G. Barandica. Colaboradores del área de Filosofía: J.H. Evans Civit, D. Lema Sarmento, T. Squizzato, I. Anton Mlinar; ISBN 978-987-1240-53-1; 640 pág.

Fil: Bieda, Esteban.

Jorge H. Evans Civit (ed.), Antología del Index Aristotelicus de H. Bonitz, Buenos Aires, Santiago Arcos, 2010. Colaboradores del área de Lenguas Clásicas: L. Sardi de Estrella, E. Driban, E. Cecco, M.E. Guevara de Álvarez, C. Silventi, M.G. Barandica. Colaboradores del área de Filosofía: J.H. Evans Civit, D. Lema Sarmento, T. Squizzato, I. Anton Mlinar

Fil: Bieda, Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas

Guatemala-Honduras boundary arbitration; reply of Guatemala to the counter case of Honduras submitted to the Arbitral tribunal composed of: the Hon. Charles Evans Hughes, chief justice of the United States of America; Hon. Luis Castro Ureña, from Costa Rica; Hon. Emilio Bello Codesdido, from Chile. Under treaty of July 16, 1930.

"Annex number 189. Report relating to the construction of the hypsometric map of the republic of Guatemala drawn under the supervision of the engineering staff of the Guatemala boundary commission, by order of the government of the republic": p. 178-183. Signed: Guatemala, September 29, 1928. Claudio Urrutia.

Intermittent access to 20% ethanol induces high ethanol consumption in Long-Evans and Wistar rats

BACKGROUND: There has been some difficulty getting standard laboratory rats to voluntarily consume large amounts of ethanol without the use of initiation procedures. It has previously been shown that standard laboratory rats will voluntarily consume high levels of ethanol if given intermittent-access to 20% ethanol in a 2-bottle-choice setting [Wise, Psychopharmacologia 29 (1973), 203]. In this study, we have further characterized this drinking model. METHODS: Ethanol-naïve Long-Evans rats were given intermittent-access to 20% ethanol (three 24-hour sessions per week). No sucrose fading was needed and water was always available ad libitum. Ethanol consumption, preference, and long-term drinking behaviors were investigated. Furthermore, to pharmacologically validate the intermittent-access 20% ethanol drinking paradigm, the efficacy of acamprosate and naltrexone in decreasing ethanol consumption were compared with those of groups given continuous-access to 10 or 20% ethanol, respectively. Additionally, ethanol consumption was investigated in Wistar and out-bred alcohol preferring (P) rats following intermittent-access to 20% ethanol. RESULTS: The intermittent-access 20% ethanol 2-bottle-choice drinking paradigm led standard laboratory rats to escalate their ethanol intake over the first 5 to 6 drinking sessions, reaching stable baseline consumption of high amounts of ethanol (Long-Evans: 5.1 +/- 0.6; Wistar: 5.8 +/- 0.8 g/kg/24 h, respectively). Furthermore, the cycles of excessive drinking and abstinence led to an increase in ethanol preference and increased efficacy of both acamprosate and naltrexone in Long-Evans rats. P-rats initiate drinking at a higher level than both Long-Evans and Wistar rats using the intermittent-access 20% ethanol paradigm and showed a trend toward a further escalation in ethanol intake over time (mean ethanol intake: 6.3 +/- 0.8 g/kg/24 h). CONCLUSION: Standard laboratory rats will voluntarily consume ethanol using the intermittent-access 20% ethanol drinking paradigm without the use of any initiation procedures. This model promises to be a valuable tool in the alcohol research field.

Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats

Abstract RATIONALE: Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol seeking. In the current study, we examined the role of orexin-1/hypocretin-1 receptors in operant self-administration of ethanol and sucrose and in yohimbine-induced reinstatement of ethanol and sucrose seeking. MATERIALS AND METHODS: Rats were trained to self-administer either 10% ethanol or 5% sucrose (30 min/day). The orexin-1 receptor antagonist SB334867 (0, 5, 10, 15, 20 mg/kg, i.p.) was administered 30 min before the operant self-administration sessions. After these experiments, the operant self-administration behaviors were extinguished in both the ethanol and sucrose-trained rats. Upon reaching extinction criteria, SB334867 (0, 5, 10 mg/kg, i.p.) was administered 30 min before yohimbine (0 or 2 mg/kg, i.p.). In a separate experiment, the effect of SB334867 (0, 15, or 20 mg/kg, i.p.) on general locomotor activity was determined using the open-field test. RESULTS: The orexin-1 receptor antagonist, SB334867 (10, 15 and 20 mg/kg) decreased operant self-administration of 10% ethanol but not 5% sucrose self-administration. Furthermore, SB334867 (5 and 10 mg/kg) significantly decreased yohimbine-induced reinstatement of both ethanol and sucrose seeking. SB334867 did not significantly affect locomotor activity measured using the open-field test. CONCLUSIONS: The results suggest that inhibition of OX-1/Hcrt-1 receptors modulates operant ethanol self-administration and also plays a significant role in yohimbine-induced reinstatement of both ethanol and sucrose seeking in rats.

Long-evans rats acquire operant self-administration of 20% ethanol without sucrose fading

A major obstacle in the development of new medications for the treatment of alcohol use disorders (AUDs) has been the lack of preclinical, oral ethanol consumption paradigms that elicit high consumption. We have previously shown that rats exposed to 20% ethanol intermittently in a two-bottle choice paradigm will consume two times more ethanol than those given continuous access without the use of water deprivation or sucrose fading (5-6 g/kg every 24 h vs 2-3 g/kg every 24 h, respectively). In this study, we have adapted the model to an operant self-administration paradigm. Long-Evans rats were given access to 20% ethanol in overnight sessions on one of two schedules: (1) intermittent (Monday, Wednesday, and Friday) or (2) daily (Monday through Friday). With the progression of the overnight sessions, both groups showed a steady escalation in drinking (3-6 g/kg every 14 h) without the use of a sucrose-fading procedure. Following the acquisition phase, the 20% ethanol groups consumed significantly more ethanol than did animals trained to consume 10% ethanol with a sucrose fade (1.5 vs 0.7 g/kg every 30 min) and reached significantly higher blood ethanol concentrations. In addition, training history (20% ethanol vs 10% ethanol with sucrose fade) had a significant effect on the subsequent self-administration of higher concentrations of ethanol. Administration of the pharmacological stressor yohimbine following extinction caused a significant reinstatement of ethanol-seeking behavior. Both 20% ethanol models show promise and are amenable to the study of maintenance, motivation, and reinstatement. Furthermore, training animals to lever press for ethanol without the use of sucrose fading removes a potential confound from self-administration studies. © 2010 Nature Publishing Group All rights reserved.

Numerical computation of an Evans function for travelling waves

We demonstrate a geometrically inspired technique for computing Evans functions for the linearised operators about travelling waves. Using the examples of the F-KPP equation and a Keller–Segel model of bacterial chemotaxis, we produce an Evans function which is computable through several orders of magnitude in the spectral parameter and show how such a function can naturally be extended into the continuous spectrum. In both examples, we use this function to numerically verify the absence of eigenvalues in a large region of the right half of the spectral plane. We also include a new proof of spectral stability in the appropriate weighted space of travelling waves of speed c≥sqrt(2δ) in the F-KPP equation.

Hermano de hombre soy : Entrevista al P. Juan Carlos Scannone S.I. sobre la mediación de la filosofía en el diálogo entre literatura y teología

Tres miembros del Seminario Interdisciplinario Permanente de Literatura, Estética y Teología entrevistaron a Juan Carlos Scannone en búsqueda de una conversación que abra nuevas perspectivas. Los temas principales fueron: el inicio de Scannone en el diálogo entre literatura y teología, la formación humanística de los jesuitas, los precursores en la Argentina, la mediación simbólica, los aportes de Paul Ricoeur, el método interdisciplinario y la mediación filosófica, la novela latinoamericana.

La recepción de la obra de Carlos Vega

Resumen: En la primera parte de este artículo se mencionan textos sobre aspectos de la obra de Carlos Vega publicados en revistas científicas argentinas y en similares sedes de otros países, así como trabajos de este autor reeditados con posterioridad a su muerte. En la segunda se comentan los capítulos que conformarán el libro Estudios sobre la obra de Carlos Vega, de próxima publicación, algunos de los cuales ya aparecieron en años anteriores mientras que otros han sido escritos especialmente para la ocasión.

Carlos Vega dramaturgo

Entre los papeles que integran el Fondo Documental “Carlos Vega” del Instituto de Investigación Musicológica de la Universidad Católica Argentina, se encuentra un testimonio de lo que podría considerarse una de las primeras aproximaciones de Carlos Vega al teatro: es el programa de una velada literario-musical organizada por la Escuela Normal Popular en “honor de sus primeras egresadas” en el Teatro de la Sociedad Italiana de Cañuelas. En la función del domingo 24 de septiembre de 1916, participó como actor en dos pasos de comedia, en el denominado Lo imprevisto y en el que cerró el espectáculo, Los pantalones. También en su transcurso recitó el monólogo Vísperas de boda. En el programa no se indican autores, lo que abre el interrogante sobre si quizás además colaboró en alguno de estos monólogos en tal condición, pues en esos años ya se ejercitaba como escritor.

Lauro Ayestarán, Carlos Vega, y las dos orillas del Río de la Plata

Resumen: El texto explora el diálogo de las dos figuras fundacionales de la musicología de Argentina y Uruguay: de Vega como maestro y Ayestarán como discípulo, y de ambos como amigos. La rica correspondencia que mantuvieran durante casi tres décadas permite recorrer diversas características de sus personalidades, que se centran obsesivamente en el rigor y en la entrega pero que no excluyen el humor y la ternura. Se aportan observaciones acerca de la compleja relación de ambos con otras personalidades del medio musical argentino.

Relatos inéditos de Carlos Vega

En 1932, Carlos Vega publica Agua, una colección de microrrelatos o, mejor, “cuentos mínimos”, según aparece en el subtítulo de la obra. Antes de Agua, Vega ya había dado a conocer Hombre (1926) y Campo (1927), dos libros de poesía. Éstas fueron las únicas obras literarias de Carlos Vega que se editaron en forma de libro, pero sabemos que más allá de estos textos, se conservan inéditas varias obras de teatro, algunos poemas sueltos y un puñado de narraciones.

El libro “El himno nacional argentino” de Carlos Vega

Resumen: Conferencia destinada a analizar el texto de Carlos Vega a la luz de algunos antecedentes producidos por el mismo autor sobre la materia y de textos de otros autores citados en la bibliografía.