Del haereticus como enemigo externo al haereticus como cristiano imperfecto en el corpus de Cromacio de Aquileya

El objetivo de este trabajo es reflexionar acerca del significado que el término haereticus adquiere en el discurso de Cromacio de Aquileya. Se procurará demostrar que haereticus contiene en su corpus una doble dimensión semántica: por un lado, en su acepción más inmediata, designa al cristiano abiertamente disidente respecto de la ortodoxia local; por otro, la lectura atenta de los Sermones y del Tractatus in Mathaeum permite apreciar que Cromacio empleaba el concepto para referir a algunos miembros de la propia comunidad cristiana cuyas conductas y creencias acaso no se adecuaban a las exigencias de la nueva fe. Al mismo tiempo, pues, el término haereticus resultaba un útil instrumento para la catequesis, puesto que pretendía instruir a estos cristianos imperfectos en la especificidad de la identidad cristiana, y un instrumento coercitivo, ya que aspiraba a que el temor a merecer en vida y tras la muerte las sanciones destinadas al haereticus externo y arquetípico contribuyera a la completa asunción de las consecuencias del acto de conversión

Del haereticus como enemigo externo al haereticus como cristiano imperfecto en el corpus de Cromacio de Aquileya

El objetivo de este trabajo es reflexionar acerca del significado que el término haereticus adquiere en el discurso de Cromacio de Aquileya. Se procurará demostrar que haereticus contiene en su corpus una doble dimensión semántica: por un lado, en su acepción más inmediata, designa al cristiano abiertamente disidente respecto de la ortodoxia local; por otro, la lectura atenta de los Sermones y del Tractatus in Mathaeum permite apreciar que Cromacio empleaba el concepto para referir a algunos miembros de la propia comunidad cristiana cuyas conductas y creencias acaso no se adecuaban a las exigencias de la nueva fe. Al mismo tiempo, pues, el término haereticus resultaba un útil instrumento para la catequesis, puesto que pretendía instruir a estos cristianos imperfectos en la especificidad de la identidad cristiana, y un instrumento coercitivo, ya que aspiraba a que el temor a merecer en vida y tras la muerte las sanciones destinadas al haereticus externo y arquetípico contribuyera a la completa asunción de las consecuencias del acto de conversión

Del haereticus como enemigo externo al haereticus como cristiano imperfecto en el corpus de Cromacio de Aquileya

El objetivo de este trabajo es reflexionar acerca del significado que el término haereticus adquiere en el discurso de Cromacio de Aquileya. Se procurará demostrar que haereticus contiene en su corpus una doble dimensión semántica: por un lado, en su acepción más inmediata, designa al cristiano abiertamente disidente respecto de la ortodoxia local; por otro, la lectura atenta de los Sermones y del Tractatus in Mathaeum permite apreciar que Cromacio empleaba el concepto para referir a algunos miembros de la propia comunidad cristiana cuyas conductas y creencias acaso no se adecuaban a las exigencias de la nueva fe. Al mismo tiempo, pues, el término haereticus resultaba un útil instrumento para la catequesis, puesto que pretendía instruir a estos cristianos imperfectos en la especificidad de la identidad cristiana, y un instrumento coercitivo, ya que aspiraba a que el temor a merecer en vida y tras la muerte las sanciones destinadas al haereticus externo y arquetípico contribuyera a la completa asunción de las consecuencias del acto de conversión

Der Römerbrieftext des Rufin und seine Origenes-Übersetzung /

Includes index.

Der Römerbriefkommentar des Origenes : kritische Ausgabe der Übersetzung Rufins, /

Text in Latin, explanatory matters in German.

[Phlabiou Iōsēpou Hierosolymitou hiereōs Ta heuriskomena] = Flavii Josephi Hierosolymitani sacerdotis Opera quae extant omnia : nempe, Antiquitatum Judaicarum libri XX Sigismundo Gelenio interprete, De bello Judaico libri VII interprete Rufino Aquilejensi, Liber de vita sua cum interpretatione Gelenii, Adversus Apionem libri II cum versione antiqua à Gelenio emendata, & De Maccabaeis seu de imperio rationis liber cum paraphrasi Erasmi Roterodami : accedit index locupletissimus : juxta editionem Graeco-Latinam Genevensem ad manuscriptos Palatinae bibliothecae codices castigatam quae nunc à pluribus mendis expurgata & praeterea prolegomenis & appendice auctior redditur.

Signatures: a-f⁶ A-3M⁶ 3N⁴ 3O-4Z⁶ [chi]¹ *⁴ a-e⁶ f⁴ *⁶ 2*⁸; preliminary a5-6 signed *5-6.

Ss. episcoporum Nicetae et Paulini scripta ex Vaticanio codibus edita

Mode of access: Internet.

Origines De principiis /

Greek text followed by the Latin translation of Rufinus.

Pipkiiα Is Widely Expressed In Hematopoietic-derived Cells And May Play A Role In The Expression Of Alpha- And Gamma-globins In K562 Cells.

Characterized for the first time in erythrocytes, phosphatidylinositol phosphate kinases (PIP kinases) belong to a family of enzymes that generate various lipid messengers and participate in several cellular processes, including gene expression regulation. Recently, the PIPKIIα gene was found to be differentially expressed in reticulocytes from two siblings with hemoglobin H disease, suggesting a possible relationship between PIPKIIα and the production of globins. Here, we investigated PIPKIIα gene and protein expression and protein localization in hematopoietic-derived cells during their differentiation, and the effects of PIPKIIα silencing on K562 cells. PIPKIIα silencing resulted in an increase in α and γ globins and a decrease in the proliferation of K562 cells without affecting cell cycle progression and apoptosis. In conclusion, using a cell line model, we showed that PIPKIIα is widely expressed in hematopoietic-derived cells, is localized in their cytoplasm and nucleus, and is upregulated during erythroid differentiation. We also showed that PIPKIIα silencing can induce α and γ globin expression and decrease cell proliferation in K562 cells.

The Clinical Impact Of Cerebellar Grey Matter Pathology In Multiple Sclerosis.

The cerebellum is an important site for cortical demyelination in multiple sclerosis, but the functional significance of this finding is not fully understood. To evaluate the clinical and cognitive impact of cerebellar grey-matter pathology in multiple sclerosis patients. Forty-two relapsing-remitting multiple sclerosis patients and 30 controls underwent clinical assessment including the Multiple Sclerosis Functional Composite, Expanded Disability Status Scale (EDSS) and cerebellar functional system (FS) score, and cognitive evaluation, including the Paced Auditory Serial Addition Test (PASAT) and the Symbol-Digit Modalities Test (SDMT). Magnetic resonance imaging was performed with a 3T scanner and variables of interest were: brain white-matter and cortical lesion load, cerebellar intracortical and leukocortical lesion volumes, and brain cortical and cerebellar white-matter and grey-matter volumes. After multivariate analysis high burden of cerebellar intracortical lesions was the only predictor for the EDSS (p<0.001), cerebellar FS (p = 0.002), arm function (p = 0.049), and for leg function (p<0.001). Patients with high burden of cerebellar leukocortical lesions had lower PASAT scores (p = 0.013), while patients with greater volumes of cerebellar intracortical lesions had worse SDMT scores (p = 0.015). Cerebellar grey-matter pathology is widely present and contributes to clinical dysfunction in relapsing-remitting multiple sclerosis patients, independently of brain grey-matter damage.

Dna Extraction From Filter-paper Spots Of Vaginal Samples Collected After Sexual Violence.

To detect the presence of male DNA in vaginal samples collected from survivors of sexual violence and stored on filter paper. A pilot study was conducted to evaluate 10 vaginal samples spotted on sterile filter paper: 6 collected at random in April 2009 and 4 in October 2010. Time between sexual assault and sample collection was 4-48hours. After drying at room temperature, the samples were placed in a sterile envelope and stored for 2-3years until processing. DNA extraction was confirmed by polymerase chain reaction for human β-globin, and the presence of prostate-specific antigen (PSA) was quantified. The presence of the Y chromosome was detected using primers for sequences in the TSPY (Y7/Y8 and DYS14) and SRY genes. β-Globin was detected in all 10 samples, while 2 samples were positive for PSA. Half of the samples amplified the Y7/Y8 and DYS14 sequences of the TSPY gene and 30% amplified the SRY gene sequence of the Y chromosome. Four male samples and 1 female sample served as controls. Filter-paper spots stored for periods of up to 3years proved adequate for preserving genetic material from vaginal samples collected following sexual violence.

Analysis Of The Dna Fourier Transform-infrared Microspectroscopic Signature Using An All-reflecting Objective.

The Fourier transform-infrared (FT-IR) signature of dry samples of DNA and DNA-polypeptide complexes, as studied by IR microspectroscopy using a diamond attenuated total reflection (ATR) objective, has revealed important discriminatory characteristics relative to the PO2(-) vibrational stretchings. However, DNA IR marks that provide information on the sample's richness in hydrogen bonds have not been resolved in the spectral profiles obtained with this objective. Here we investigated the performance of an all reflecting objective (ARO) for analysis of the FT-IR signal of hydrogen bonds in DNA samples differing in base richness types (salmon testis vs calf thymus). The results obtained using the ARO indicate prominent band peaks at the spectral region representative of the vibration of nitrogenous base hydrogen bonds and of NH and NH2 groups. The band areas at this spectral region differ in agreement with the DNA base richness type when using the ARO. A peak assigned to adenine was more evident in the AT-rich salmon DNA using either the ARO or the ATR objective. It is concluded that, for the discrimination of DNA IR hydrogen bond vibrations associated with varying base type proportions, the use of an ARO is recommended.

Antiangiogenic And Finasteride Therapies: Responses Of The Prostate Microenvironment In Elderly Mice.

The aim of this study was to evaluate the structural and molecular effects of antiangiogenic therapies and finasteride on the ventral prostate of senile mice. 90 male FVB mice were divided into: Young (18 weeks old) and senile (52 weeks old) groups; finasteride group: finasteride (20mg/kg); SU5416 group: SU5416 (6 mg/kg); TNP-470 group: TNP-470 (15 mg/kg,) and SU5416+TNP-470 group: similar to the SU5416 and TNP-470 groups. After 21 days, prostate ventral lobes were collected for morphological, immunohistochemical and Western blotting analyses. The results demonstrated atrophy, occasional proliferative lesions and inflammatory cells in the prostate during senescence, which were interrupted and/or blocked by treatment with antiangiogenic drugs and finasteride. Decreased AR and endostatin reactivities, and an increase for ER-α, ER-β and VEGF, were seen in the senile group. Decreased VEGF and ER-α reactivities and increased ER-β reactivity were verified in the finasteride, SU5416 groups and especially in SU5416+TNP-470 group. The TNP-470 group showed reduced AR and ER-β protein levels. The senescence favored the occurrence of structural and/or molecular alterations suggesting the onset of malignant lesions, due to the imbalance in the signaling between the epithelium and stroma. The SU5416+TNP-470 treatment was more effective in maintaining the structural, hormonal and angiogenic factor balance in the prostate during senescence, highlighting the signaling of antiproliferation via ER-β.

An Efficient Protocol For The Generation Of Monocyte Derived Dendritic Cells Using Serum-free Media For Clinical Applications In Post Remission Aml Patients.

Protocols for the generation of dendritic cells (DCs) using serum as a supplementation of culture media leads to reactions due to animal proteins and disease transmissions. Several types of serum-free media (SFM), based on good manufacture practices (GMP), have recently been used and seem to be a viable option. The aim of this study was to evaluate the results of the differentiation, maturation, and function of DCs from Acute Myeloid Leukemia patients (AML), generated in SFM and medium supplemented with autologous serum (AS). DCs were analyzed by phenotype characteristics, viability, and functionality. The results showed the possibility of generating viable DCs in all the conditions tested. In patients, the X-VIVO 15 medium was more efficient than the other media tested in the generation of DCs producing IL-12p70 (p=0.05). Moreover, the presence of AS led to a significant increase of IL-10 by DCs as compared with CellGro (p=0.05) and X-Vivo15 (p=0.05) media, both in patients and donors. We concluded that SFM was efficient in the production of DCs for immunotherapy in AML patients. However, the use of AS appears to interfere with the functional capacity of the generated DCs.

Changes In The Bacterial Community Of Soil From A Neutral Mine Drainage Channel.

Mine drainage is an important environmental disturbance that affects the chemical and biological components in natural resources. However, little is known about the effects of neutral mine drainage on the soil bacteria community. Here, a high-throughput 16S rDNA pyrosequencing approach was used to evaluate differences in composition, structure, and diversity of bacteria communities in samples from a neutral drainage channel, and soil next to the channel, at the Sossego copper mine in Brazil. Advanced statistical analyses were used to explore the relationships between the biological and chemical data. The results showed that the neutral mine drainage caused changes in the composition and structure of the microbial community, but not in its diversity. The Deinococcus/Thermus phylum, especially the Meiothermus genus, was in large part responsible for the differences between the communities, and was positively associated with the presence of copper and other heavy metals in the environmental samples. Other important parameters that influenced the bacterial diversity and composition were the elements potassium, sodium, nickel, and zinc, as well as pH. The findings contribute to the understanding of bacterial diversity in soils impacted by neutral mine drainage, and demonstrate that heavy metals play an important role in shaping the microbial population in mine environments.