998 resultados para Charles Stewart Mott Foundation.


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This letter was written aboard the U.S.S. Franklin. Stewart writes in detail about William’s brother Henry James (Harry) Tudor, and concerns about his character, particularly his "natural indolence and indifference." He notes that like his wife, Delia, Harry spends money irresponsibly. Stewart also writes he tried to interest Harry in the pursership of the Franklin, and had hoped he would be appointed to the Consulate of Tripoli or Tunis.

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Mode of access: Internet.

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Stress is the most commonly reported precipitating factor for seizures in patients with epilepsy. Despite compelling anecdotal evidence for stress-induced seizures, animal models of the phenomena are sparse and possible mechanisms are unclear. Here, we tested the hypothesis that increased levels of the stress-associated hormone corticosterone ( CORT) would increase epileptiform activity and spontaneous seizure frequency in mice rendered epileptic following pilocarpine-induced status epilepticus. We monitored video-EEG activity in pilocarpine-treated mice 24/7 for a period of four or more weeks, during which animals were serially treated with CORT or vehicle. CORT increased the frequency and duration of epileptiform events within the first 24 hours of treatment, and this effect persisted for up to two weeks following termination of CORT injections. Interestingly, vehicle injection produced a transient spike in CORT levels - presumably due to the stress of injection - and a modest but significant increase in epileptiform activity. Neither CORT nor vehicle treatment significantly altered seizure frequency; although a small subset of animals did appear responsive. Taken together, our findings indicate that treatment of epileptic animals with exogenous CORT designed to mimic chronic stress can induce a persistent increase in interictal epileptiform activity.

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Four letters written from Gardiner, Maine, in which Mrs. Tudor comments on the marital troubles between Delia and Charles Stewart, and general happenings at Oaklands.

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One letter in which Tudor writes of his relief at the acquittal of his brother-in-law Charles Stewart at a court martial. He also discusses speculation and trade, his shares in silver mines at Bella Vista and Chanca, Peru, and the political climate. He additionally references his role in planning the monument at Bunker Hill in Charlestown, writing, "I had something to do in originating and preparing the way for the Bunker Hill monunument, a truly patriotic object, which I believed was a proper way to excite public enthusiasm."

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Five letters in which Lee relays his efforts to obtain a political appointment for Tudor from President James Monroe. He also reports on the activities of Tudor’s brother-in-law, Charles Stewart, and a meeting between John Quincy Adams and Tudor’s brother-in-law, Robert Hallowell Gardiner.