Infraspinatus Kontraktur beim Cavalier King Charles

Ein 6,5 Jahre alter Cavalier King Charles Spaniel wurde mit einer seit 6 Wochen bestehenden Lahmheit der linken Vorderextremität vorgestellt. In der klinischen Untersuchung wurden eine Abduktion der linken Vordergliedmaße, eine Atrophie des M. infraspinatus, M. supraspinatus und M. deltoideus, eine Dolenz bei Palpation bzw. Flexion des Schultergelenks sowie eine mittelgradige Hangbeinlahmheit mit charakteristischer Aussenrotation der Schulter festgestellt. Als Diagnose wurde eine Kontraktur des M. infraspinatus gestellt, und die komplette Tenektomie seiner Ansatzsehne führte zur Wiederherstellung der normalen Gliedmaßenfunktion.

Mutation in beta1-tubulin correlates with macrothrombocytopenia in Cavalier King Charles Spaniels.

BACKGROUND Cavalier King Charles Spaniels (CKCS) have a high prevalence of inherited macrothrombocytopenia. The purpose of this study was to determine if a mutation in beta1-tubulin correlated with presumptive inherited macrothrombocytopenia. HYPOTHESIS A mutation in beta1-tubulin results in synthesis of an altered beta1-tubulin monomer. alpha-beta tubulin dimers within microtubule protofilaments are unstable, resulting in altered megakaryocyte proplatelet formation. ANIMALS Blood samples were obtained from CKCS and non-CKCS dogs. METHODS DNA was used in polymerase chain reaction (PCR) assays to evaluate beta1-tubulin. Platelet numbers and mean platelet volume (MPV) were evaluated for a correlation with the presence or absence of a mutation identified in beta1-tubulin. Platelets obtained from homozygous, heterozygous, and clear CKCS were further evaluated using electron microscopy and immunofluorescence. RESULTS A mutation in the gene encoding beta1-tubulin correlated with macrothrombocytopenia in CKCS. Electron microscopy and immunofluorescence studies suggest that platelet microtubules are present but most likely are unstable and decreased in number. CONCLUSIONS AND CLINICAL IMPORTANCE The macrothrombocytopenia of CKCS correlated with a mutation in beta1-tubulin. alpha-beta tubulin dimers within protofilaments most likely are unstable, leading to altered proplatelet formation by megakaryocytes. This information will aid in distinguishing inherited from acquired thrombocytopenia. It also provides insight into the mechanism of platelet production by megakaryocytes, and also may prove useful in understanding heart-related changes in macrothrombocytopenic CKCS with concurrent mitral valve regurgitation.

Avaliação comparativa dos efeitos do anlodipino e da pimobendana na insuficiência valvar crônica de mitral em cães

A insuficiência valvar crônica de mitral (IVCM) é a principal cardiopatia de cães, correspondendo a 75-85% dos casos de cardiopatias. É causada pela degeneração mixomatosa da valva mitral (endocardiose de mitral) sendo, então, uma doença degenerativa adquirida e que pode ocasionar a insuficiência cardíaca congestiva (ICC). Pode acometer qualquer raça de cão, mas é mais frequentemente observada nas raças de pequeno porte, dentre as quais, Poodle miniatura, Spitz Alemão, Dachshund, Yorkshire Terrier, Chihuahua e Cavalier King Charles Spaniel. Na endocardiose de mitral, o volume sanguíneo regurgitado causa sobrecarga do lado esquerdo do coração, devido ao aumento das pressões atrial e ventricular esquerdas, seguida de dilatação e hipertrofia dessas cavidades cardíacas. A elevação da pressão ventricular esquerda pode causar hipertensão pulmonar, congestão e, em estágios avançados, edema pulmonar. A doença pode evoluir assintomática, enquanto que naqueles casos que evoluem para insuficiência cardíaca congestiva (ICC) os sintomas mais usuais são: tosse, intolerância ao exercício, dispneia e síncope. Em 2009 o colégio americano de medicina interna veterinária (American College of Veterinary Internal Medicine -ACVIM) elaborou diretrizes para o tratamento da IVCM, tendo por base a classificação funcional adaptada do American College of Cardiology. Neste trabalho foram utilizados os fármacos anlodipino e pimobendana em associação a outros usualmente indicados no tratamento da ICC em cães, segundo consenso de 2009, indicados no tratamento da ICC em cães. Dois grupos (A e B) de cães, cada um constituído por 10 pacientes com IVCM em estágio C, foram tratados com furosemida e maleato de enalapril, sendo que os animais do grupo A receberão pimobendana e os do grupo B, anlodipino. Os animais foram avaliados em diferentes momentos (T0, T30, T60) observando-se as alterações nos exames ecodopplercardiográfico e eletrocardiográfico, bem como de pressão arterial sistólica

Clínica de animais de companhia

O presente relatório é resultado do estágio curricular, 11º semestre do Mestrado Integrado em Medicina Veterinária. Este decorreu em duas instituições de referência veterinária em Barcelona (Hospital ARS Veterinária e Hospital Veterinari Montjuïc) e permitiu melhorar e integrar os conhecimentos adquiridos ao longo do curso. O relatório é composto por três partes: introdução, que situa temporal e espacialmente, relatório de casuística, que abrange todas as atividades realizadas e assistidas, e monografia. A monografia consiste na descrição de uma afeção neurológica, muito comum em Cavalier king charles spaniel, designada de siringomielia. A monografia inicia-se com uma revisão bibliográfica e termina com o relato de quatro casos clínicos acompanhados no Hospital ARS Veterinário; ABSTRACT: Small animal practice This report is the result of the traineeship in the 11th semester of the Integrated Master degree in Veterinary Medicine. It took place in two veterinary reference institutions in Barcelona (hospital ARS veterinary and hospital Veterinari Montjuïc) and contributed to improve and integrate the knowledge acquired throughout the course. The report consists in three parts: Introduction, which locates temporally and spatially, the sample report covering all activities, and monograph. The monography is the description of a neurological disorder, very common in Cavalier king charles spaniel, designated syringomyelia. The monography begins with a literature review and ends with the description of four clinical cases followed in ARS veterinary hospital.

The royal charter of King Charles the Second to William Penn, esquire, proprietor of the province of Pennsylvania, 1701

A copy of the charter giving William Penn land in the colonies. Also contains Penn's "Frame of the Government of Pennsylvania in America", the laws he established, and the charter of the city of Philadelphia.

Memorials of the English affairs from the beginning of the reign of Charles the First to the happy restoration of King Charles the Second.

Reprint of the edition of 1732.

Diary and correspondence of John Evelyn, F. R. S. To which is subjoined the private correspondence between King Charles I. and Sir Edward Nicholas, and between Sir Edward Hyde, afterwards earl of Clarendon, and Sir Richard Browne.

Mode of access: Internet.

Memoirs of John Evelyn ... comprising his diary, from 1641-1705-6, and a selection of his familiar letters, to which is subjoined, the private correspondence between King Charles I. and Sir Edward Nicholas; also between Sir Edward Hyde, afterwards Earl of Clarendon, and Sir Richard Browne, ambassador to the Court of France, in the time of King Charles I. and the usurpation.

Mode of access: Internet.

An ecclesiastical history of Great Britain; chiefly of England, from the first planting of Christianity, to the end of the reign of King Charles the Second; with a brief account of the affairs of religion in Ireland. Collected from the best ancient historians, councils, and records,

Mode of access: Internet.

A chronicle of the kings of England. From the time of the Romans government, unto the death of King James. Containing all passages of state and church, with all other observations proper for a chronicle ... Whereunto is added, the reign of King Charles the first, and the first thirteen years of his sacred majesty, King Charles the second ... All which additions are revised in this eighth impression, and freed from many errors and mistakes of the former editions.

The histories of Charles the first and Charles the second are by Edward Phillips; the account of the restoration is by Sir Thomas Clarges--Dict. of Nat. Biog.

Memoirs of the life and writings of Ben Jonson, Esq; poet laureat to King James the First, and King Charles the First.

The Widow [and] Eastward Hoe each have separate title-pages.

A catalogue and description of King Charles the first's capital collection of pictures, limnings, statues, bronzes, medals, and other curiosities : now first published from an original manuscript in the Ashmolean Musæum at Oxford /

Includes index.

Memoirs of the court of King Charles the First.

Mode of access: Internet.

An essay towards attaining a true idea of the character and reign of King Charles the First and the causes of the civil war : extracted from and delivered in the very words of some of the most authentic and celebrated historians viz. Clarendon, Whitelock, Burnet, Coke, Echard, Rapin, Tindal, Neal, &c.

Published anonymously. Attributed to Micaiah Towgood by ESTC.

The life of Merlin, surnamed Ambrosius; his prophecies and predictions interpreted, and their truth made good by our English annals: being a chronographical history of all the kings and memorable passages of this kingdom, from Brute to the reign of King Charles.

Preface, "To the reader," signed: Thomas Heywood.