Increased opioid dependence in a mouse model of panic disorder

[EN] Panic disorder is a highly prevalent neuropsychiatric disorder that shows co-occurrence with substance abuse. Here, we demonstrate that TrkC, the high-affinity receptor for neurotrophin-3, is a key molecule involved in panic disorder and opiate dependence, using a transgenic mouse model (TgNTRK3). Constitutive TrkC overexpression in TgNTRK3 mice dramatically alters spontaneous firing rates of locus coeruleus (LC) neurons and the response of the noradrenergic system to chronic opiate exposure, possibly related to the altered regulation of neurotrophic peptides observed. Notably, TgNTRK3 LC neurons showed an increased firing rate in saline-treated conditions and profound abnormalities in their response to met5-enkephalin. Behaviorally, chronic morphine administration induced a significantly increased withdrawal syndrome in TgNTRK3 mice. In conclusion, we show here that the NT-3/TrkC system is an important regulator of neuronal firing in LC and could contribute to the adaptations of the noradrenergic system in response to chronic opiate exposure. Moreover, our results indicate that TrkC is involved in the molecular and cellular changes in noradrenergic neurons underlying both panic attacks and opiate dependence and support a functional endogenous opioid deficit in panic disorder patients.

Fast and Efficient Neural Conversion of Human Hematopoietic Cells

Neurons obtained directly from human somatic cells hold great promise for disease modeling and drug screening. Available protocols rely on overexpression of transcription factors using integrative vectors and are often slow, complex, and inefficient. We report a fast and efficient approach for generating induced neural cells (iNCs) directly from human hematopoietic cells using Sendai virus. Upon SOX2 and c-MYC expression, CD133-positive cord blood cells rapidly adopt a neuroepithelial morphology and exhibit high expansion capacity. Under defined neurogenic culture conditions, they express mature neuronal markers and fire spontaneous action potentials that can be modulated with neurotransmitters. SOX2 and c-MYC are also sufficient to convert peripheral blood mononuclear cells into iNCs. However, the conversion process is less efficient and resulting iNCs have limited expansion capacity and electrophysiological activity upon differentiation. Our study demonstrates rapid and efficient generation of iNCs from hematopoietic cells while underscoring the impact of target cells on conversion efficiency.

Tres eixos en l'atenció a la salut integral de l'adolescent. 'Tres ejes en la atención de la salud integral del adolescente'.

Resumen basado en el del autor en catalán

Trastorno por déficit de atención con ou sen hiperactividade. 'Trastorno por deficit de atención con o sin hiperactividad'.

Resumen basado en el de la publicación

Agresividade e violencia en nenos e adolescentes. 'Agresividad y violencia en niños y adolescentes'.

Resumen basado en el de la publicación

El mestre Canaletes i «El cuento del formigó»

En aquest article s’aporten dades biogràfiques sobre Josep Canals i Jiménez, el Mestre Canaletes (Elx 1898 – Elx, 1985), docent emblemàtic, al Camp d’Elx, d’una època particularment interessant i significativa en la història del sistema educatiu valencià. L’aportació inclou, de més a més, la transcripció d’un manuscrit original inèdit del referit mestre Josep Canals i Jinénez: «El cuento del formigó».

Poemes de Josep Maria Llompart. 'Poemas de Josep Maria Llompart'.

Suplemento de Pissarra : revista d'ensenyament de les Illes Balears, 65. Resumen tomado de la publicación

Water available in canals and shallow sediments in St. Lucie County, Florida

The increased demand for water placed upon the water resources of St. Lucie County by the expanding agricultural use has brought about hydrologic changes with ensuing problems. This report documents these changes and provides data which are necessary in solving the problems. (PDF has 59 pages)

A coarse fish close season on canals. Paper in evidence to the review of fisheries policy and legislation. Paper number: EA-12

This paper gives the results of the Environment Agency's research into the canal close season to the Salmon and Freshwater Fisheries Review Group. It presents the findings of the research, explains why the research was undertaken and how it relates to the Agency's duties. The background for this report includes that angling representative bodies have long argued that the existing situation in which somecanals have a close season and others do not, is unsatisfactory.

Model development & application for inland navigational canals

Several agencies in the United Kingdom have interest in the water quality of old navigational canals that have fallen into disuse after the decline of commercial canal transportation. The interested agencies desired a model to predict the water quantity and quality of inland navigational canals in order to evaluate management options to address the issues in the natural streams to which they discharge. Inland navigational canals have unique drivers of their hydrology and water quality compared to either natural streams, irrigation canals, or larger navigational canals connected to seas or oceans. Water in an inland canal is typically sourced from a reservoir and artificially pumped to a summit reach; its movement downhill is controlled by the activity of boats and overflow weirs. Stagnant impoundments between locks, which might normally be expected to result in a decrease in the concentration of sediment-associated pollutants, actually have surprisingly high levels of sediment due to boat traffic. Algal growth in the stagnant reach can be high. This paper describes a canal model developed to simulate hydrology and water quality in inland navigational canals. This model was successfully applied to the Kennet and Avon Canal to predict hydrology, sediment generation and transport, and algal growth and transport. The model is responsive to external influences such as sunlight, temperature, nutrient concentrations, boat traffic, and runoff from the contributing catchment area.

Josep Cuatrecasas Arumí

Sin resumen

Welland Canals Society fonds, 1979-1991

The Welland Canals Society was a coalition of business, tourism, heritage, and recreational groups that joined with the Regional Government in 1986 to promote the redevelopment of the Welland Canals Corridor. The mandate of the Society was to provide leadership and assistance to the public and private sectors in achieving heritage-sensitive and tourism/recreation-related economic development in the Welland Canals Corridor. The Society folded in 1991 due to government funding cuts.