Brock Cameo Tie

The Brock cameo tie featuring subtle grey stripes on red was introduced in 1988 in conjunction with the 25th anniversary celebrations of Brock University. The tie is made of polyester from Bradford, England. It originally went on sale for $15.75 in the Bookstore.

A monograph on the antique cameo : the triumph of Constantine, formerly in the cabinet of Catherine II, of Russia /

Mode of access: Internet.

Mary Bell Sumner Silhouette

A photographic copy of Mary Bell Sumner silhouette n.d.

Comienza el espectáculo.

La finalidad principal de este trabajo es realizar una representación teatral, debido, sobre todo, a los resultados conseguidos en las actividades de dramatización llevadas a cabo en cursos anteriores. Algunos de los objetivos son conocer los elementos fundamentales de una obra teatral; favorecer el trabajo en equipo; fomentar el cuidado del gesto; adquirir las destrezas necesarias encaminadas al fortalecimiento de la capacidad vocal; crear y potenciar el movimiento interpretativo; desarrollar la creatividad, la expresión oral y corporal; crecer en actitudes positivas para la convivencia, la integración en el grupo, la participación o la autoestima; formarse como personas críticas, libres y constructivas; aprender a elaborar estrategias que ayuden a perder el complejo al fracaso y el miedo al ridículo; y aprender a maquillarse, vestirse y construir pequeños decorados. Las actividades consisten en la rotación de los alumnos por los diferentes talleres como el taller de relajación, respiración y vocalización; el taller de maquillaje y vestuario; el taller de decoración e iluminación; el taller de música, sonido y ritmo y el taller de juegos dramáticos. Además se representan varias obras teatrales: Peter Pan, El Parlamento de los Animales, ¿Dónde está Wally?, Full Monty, Mis Queridos Monstruos, La Tienda de las 1001 Noches, o el Fantasma de la Ópera. También se realizan exposiciones con murales-collages que anuncian las representaciones, fotografías, cuadernillos de trabajo y se visionan DVD de las representaciones. La metodología consiste en la explicación y exposición por el profesor del tema seleccionado, distribución en grupos de trabajo, anotaciones y apuntes en el cuaderno personal de cada alumno, puesta en común de los resultados y valoración de las sesiones. Se valora principalmente el sentido de la responsabilidad y el trabajo en equipo..

IntFOLD: an integrated server for modelling protein structures and functions from amino acid sequences

IntFOLD is an independent web server that integrates our leading methods for structure and function prediction. The server provides a simple unified interface that aims to make complex protein modelling data more accessible to life scientists. The server web interface is designed to be intuitive and integrates a complex set of quantitative data, so that 3D modelling results can be viewed on a single page and interpreted by non-expert modellers at a glance. The only required input to the server is an amino acid sequence for the target protein. Here we describe major performance and user interface updates to the server, which comprises an integrated pipeline of methods for: tertiary structure prediction, global and local 3D model quality assessment, disorder prediction, structural domain prediction, function prediction and modelling of protein-ligand interactions. The server has been independently validated during numerous CASP (Critical Assessment of Techniques for Protein Structure Prediction) experiments, as well as being continuously evaluated by the CAMEO (Continuous Automated Model Evaluation) project. The IntFOLD server is available at: http://www.reading.ac.uk/bioinf/IntFOLD/

Proteins and their interacting partners: an introduction to protein–ligand binding site prediction methods

Elucidating the biological and biochemical roles of proteins, and subsequently determining their interacting partners, can be difficult and time consuming using in vitro and/or in vivo methods, and consequently the majority of newly sequenced proteins will have unknown structures and functions. However, in silico methods for predicting protein–ligand binding sites and protein biochemical functions offer an alternative practical solution. The characterisation of protein–ligand binding sites is essential for investigating new functional roles, which can impact the major biological research spheres of health, food, and energy security. In this review we discuss the role in silico methods play in 3D modelling of protein–ligand binding sites, along with their role in predicting biochemical functionality. In addition, we describe in detail some of the key alternative in silico prediction approaches that are available, as well as discussing the Critical Assessment of Techniques for Protein Structure Prediction (CASP) and the Continuous Automated Model EvaluatiOn (CAMEO) projects, and their impact on developments in the field. Furthermore, we discuss the importance of protein function prediction methods for tackling 21st century problems.

In silico identification and characterization of protein-ligand binding sites

Protein–ligand binding site prediction methods aim to predict, from amino acid sequence, protein–ligand interactions, putative ligands, and ligand binding site residues using either sequence information, structural information, or a combination of both. In silico characterization of protein–ligand interactions has become extremely important to help determine a protein’s functionality, as in vivo-based functional elucidation is unable to keep pace with the current growth of sequence databases. Additionally, in vitro biochemical functional elucidation is time-consuming, costly, and may not be feasible for large-scale analysis, such as drug discovery. Thus, in silico prediction of protein–ligand interactions must be utilized to aid in functional elucidation. Here, we briefly discuss protein function prediction, prediction of protein–ligand interactions, the Critical Assessment of Techniques for Protein Structure Prediction (CASP) and the Continuous Automated EvaluatiOn (CAMEO) competitions, along with their role in shaping the field. We also discuss, in detail, our cutting-edge web-server method, FunFOLD for the structurally informed prediction of protein–ligand interactions. Furthermore, we provide a step-by-step guide on using the FunFOLD web server and FunFOLD3 downloadable application, along with some real world examples, where the FunFOLD methods have been used to aid functional elucidation.

'Creative destruction': knowledge economy policy and the future of arts and humanities in the academy

Policy conceptualizations of the global knowledge economy have led to the channelling of much Higher Education and Research and Development funding into the priority areas of science and technology. Among other things, this diversion of funding calls into question the future of traditional humanities and creative arts faculties. How these faculties, and the disciplines within them, might reconfigure themselves for the knowledge economy is, therefore, a question of great importance, although one that as yet has not been adequately answered. This paper explores some of the reasons for this by looking at how innovation in the knowledge economy is typically theorized. It takes one policy trajectory informing Australia's key innovation statement as an example. It argues that, insofar as the formation of this knowledge economy policy has been informed by a techno-economic paradigm, it works to preclude many humanities and creative arts disciplines. This paper, therefore, looks at how an alternative theorization of the knowledge economy might offer a more robust framework from within which to develop humanities and creative arts Higher Education and Research policy in the knowledge economy, both in Australia and internationally.
1 This article draws on the Australian Research Council project, Knowledge/economy/society: a sociological study of an education policy discourse in Australia in globalising circumstances, being conducted by Jane Kenway, Elizabeth Bullen and Simon Robb. This 3-year project looks at how understandings of the knowledge economy and knowledge society inform current education policy and, in turn, how this policy translates into educational practice. The methodology includes policy analysis, interviews with policy makers in government, and supranational organizations. It also includes cameo studies of innovative educational practice, two of which we draw on here.

Endocrine disrupter action in ruminants: A study of the effects of Ipomoea carnea in adult male goats

Ipomoea carnea is a toxic plant in Brazil and other tropical countries that often poisons livestock; its primary toxin is swainsonine. Some substances that interact with the endocrine system have been called endocrine disruptors (EDs). Considering swainsonine's mode of action, it is feasible to hypothesize that this compound could act as an ED. Bisphenol A (BPA), an estrogen-mimic, is considered a classical ED in rodents. This study aimed to evaluate the possible ED actions of I. cameo and BPA in male goats. Seventeen adult male goats were divided into three homogeneous groups: control (C, n = 5); IC (n = 6, received 5.0 g/kg body weight of freshly harvested I. cornea per day), and BPA (n = 6, received 25.0 mg/kg body weight of BPA per day). The experimental period was 120 days. During the experiment, blood samples were collected at 0, 30, 60, 90 and 120 days for biochemical and hormonal evaluations. On the same days, semen samples were collected for andrological evaluation, and scrotal circumference and testicular consistency were determined. The males were castrated on day 121, and fragments of testicle and epididymis were collected for histopathological evaluation. A decrease in serum T3 and T4 was observed in the IC group as well as an increase in the number of sperm with morphological alterations. In the BPA group, reduced serum 14 and a decreased percentage of sperm with plasma membrane integrates were observed. A histopathological examination revealed the vacuolar degeneration of Sertoli cells and areas of laminar patterns of calcium deposits in the IC group and vacuolar degeneration in the rete testis in the BPA group. These results indicate that both I. cameo and BPA are potential EDs in goats. This study emphasized the susceptibility of livestock to ED actions. We also demonstrated the action of I. cameo acting as EDs in the endocrine and reproductive systems. (C) 2014 Elsevier B.V. All rights reserved.

Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome

X-linked lymphoproliferative syndrome (XLP) is an inherited immunodeficiency characterized by increased susceptibility to Epstein–Barr virus (EBV). In affected males, primary EBV infection leads to the uncontrolled proliferation of virus-containing B cells and reactive cytotoxic T cells, often culminating in the development of high-grade lymphoma. The XLP gene has been mapped to chromosome band Xq25 through linkage analysis and the discovery of patients harboring large constitutional genomic deletions. We describe here the presence of small deletions and intragenic mutations that specifically disrupt a gene named DSHP in 6 of 10 unrelated patients with XLP. This gene encodes a predicted protein of 128 amino acids composing a single SH2 domain with extensive homology to the SH2 domain of SHIP, an inositol polyphosphate 5-phosphatase that functions as a negative regulator of lymphocyte activation. DSHP is expressed in transformed T cell lines and is induced following in vitro activation of peripheral blood T lymphocytes. Expression of DSHP is restricted in vivo to lymphoid tissues, and RNA in situ hybridization demonstrates DSHP expression in activated T and B cell regions of reactive lymph nodes and in both T and B cell neoplasms. These observations confirm the identity of DSHP as the gene responsible for XLP, and suggest a role in the regulation of lymphocyte activation and proliferation. Induction of DSHP may sustain the immune response by interfering with SHIP-mediated inhibition of lymphocyte activation, while its inactivation in XLP patients results in a selective immunodeficiency to EBV.

Stories by American authors.

v. 6. The village convict, by C. H. White. The Denver express, by A. A. Hayes. The misfortunes of Bro' Thomas Wheatley, by Lina R. Fairfax. The heartbreak cameo, by L. W. Champney. Miss Eunice's glove, by A. Webster. Brother Sebastian's friendship, by H. Frederic.--v. 7. The bishop's vagabond, by Octave Thanet. Lost, by E. Bellamy. Kirby's coals of fire, by Louise Stockton. Passages from the journal of a social wreck, by Margaret Floyd. Stella Grayland, by J. T. McKay. The image of San Donato, by Virginia W. Johnson.--v. 8. The brigade commander, by J. W. De Forest. Split zephyr, by H. A. Beers. Zerviah Hope, by Elizabeth S. Phelps. The life-magnet, by A. A. Adee. Osgood's predicament, by Elizabeth D. B. Stoddard.--v. 9. Marse Chan, by T. N. Page. Mr. Bixby's Christmas visitor, by C. S. Gage. Eli, by C. H. White. Young Strong of "The Clarion," by Milicent W. Shinn. How old Wiggins wore ship, by Captain R. T. Coffin. "--mas has come," by L. Kip.--v. 10. Pancha, by T. A. Janvier. The ablest man in the world, by E. P. Mitchell. Young Moll's peevy, by C. A. Stephens. Manmat'ha, by C. De Kay. A daring fiction, by H. H. Boyesen. The story of two lives, by Julia Schayer.

The works of Edgar Allan Poe ... with an introduction by Edwin Markham ...

Commerative ed.: v.1-3; Cameo ed.: v.10.

Portland Vase, front view

Glass, Roman; 9 41/64 in.x 6 31/32 in.; carved and blown, cameo glass

Portland Vase, rear view

Glass, Roman; 9 41/64 in.x 6 31/32 in.; carved and blown, cameo glass

Portland Vase, right side

Glass, Roman; 9 41/64 in.x 6 31/32 in.; carved and blown, cameo glass