Zur Erinnerung an Samuel von Brukenthal. Auss Anlass der Wiederkehr seines Geburtstages (26. Juli 1921)

Mode of access: Internet.

Student notebook of Samuel Dunbar, 1721-1722

This leather-bound volume contains substantial transcriptions copied by Samuel Dunbar from textbooks while he was a student at Harvard in 1721 and 1722. There is a general index to texts at the end of the volume. Dunbar's notebook provides a window into the state of higher education in the eighteenth century and offers a firsthand account of academic life at Harvard College. Notably, he often indicated the number of days spent copying texts into his book.

Sketches of the life of the late, Rev. Samuel Hopkins, D. D., pastor of the First Congregational church in Newport,

Mode of access: Internet.

Reminiscences of the late Rev. Samuel Hopkins, D. D., of Newport, R. I. : illustrative of his character and doctrines, with incidental subjects: From an intimacy with him of twenty-one years, while pastor of a sister church in said town /

Mode of access: Internet.

Ar Lamechs von Sirap der sündflut entrissene gesänge ... mit einer einleitung, Zeit und ewigkeit,

Cover-title.

Vollständige Beschreibung von Württemberg, in allen seinen Städten, Dörfern usw., Schlössern, Bädern, Flüssen, Bergen, Merkwürdigkeiten, wichtigen Ereignissen usw. Ein geographisch - statistich -topographisches Hand- und Hausbuch für Beamte, Kaufleute, Gewerbtreibende usw.

On spine: Moser's Beschreibung von Württemberg.

Litteratur des gesammten sowohl natürlichen als positiven Völkerrechts microform : nebst vorangeschickter Abhandlung von dem Umfange des gesammten sowohl natürlichen als positiven Völkerrechts, und Ankündigung eines zu bearbeitenden vollständigen Systems desselben /

Vol. 3 has added t.p.: Literatur des gesammten, sowohl natürlichen als positiven Völkerrechts.

Neue Literatur des Völkerrechts seit dem Jahre 1784; als Ergänzung und fortsetzung des Werks des Gesandten von Ompteda.

Added t.p.: Literatur des gesammten, sowohl natürlichen als positiven Völkerrechts, von Died. Hein. Lud. Freiherrn v. Ompteda, ergänzt und fortgesetzt von Carl Albert von Kamptz. 3. Th.

Memoirs of the life of Mrs. Sarah Osborn, who died at Newport, Rhodeisland, on the second day of August, 1796. In the eighty third year of her age.

Mode of access: Internet.

The life and character of Miss Susanna Anthony, who died, in Newport, (R.I.) June 23, 1791, in the 65th year of her age. Consisting chiefly in extracts from her writings, with some brief observations on them.

Shaw/Shoemaker 19371.

Twenty-one sermons on a variety of interesting subjects : sentimental and practical /

Mode of access: Internet.

Phylogenetic approach reveals that virus genotype largely determines HIV set-point viral load

HIV virulence, i.e. the time of progression to AIDS, varies greatly among patients. As for other rapidly evolving pathogens of humans, it is difficult to know if this variance is controlled by the genotype of the host or that of the virus because the transmission chain is usually unknown. We apply the phylogenetic comparative approach (PCA) to estimate the heritability of a trait from one infection to the next, which indicates the control of the virus genotype over this trait. The idea is to use viral RNA sequences obtained from patients infected by HIV-1 subtype B to build a phylogeny, which approximately reflects the transmission chain. Heritability is measured statistically as the propensity for patients close in the phylogeny to exhibit similar infection trait values. The approach reveals that up to half of the variance in set-point viral load, a trait associated with virulence, can be heritable. Our estimate is significant and robust to noise in the phylogeny. We also check for the consistency of our approach by showing that a trait related to drug resistance is almost entirely heritable. Finally, we show the importance of taking into account the transmission chain when estimating correlations between infection traits. The fact that HIV virulence is, at least partially, heritable from one infection to the next has clinical and epidemiological implications. The difference between earlier studies and ours comes from the quality of our dataset and from the power of the PCA, which can be applied to large datasets and accounts for within-host evolution. The PCA opens new perspectives for approaches linking clinical data and evolutionary biology because it can be extended to study other traits or other infectious diseases.