Some account of Edward Browne, of Sunderland.

Signed: T.R.

Memoir of the Rev. Edward D. Griffin, D.D., compiled chiefly from his own writings /

Mode of access: Internet.

A literary history of Persia

Title-pages of v. 3-4 read "A history of Persian literature".

The expedition of Cyrus into Persia; and the retreat of the ten thousand Greeks.

Mode of access: Internet.

The duty of a steward to his lord : represented under several plain and distinct articles; wherein may be seen the indirect practices of several stewards, tending to lessen, and the several methods likely to improve their lords estates. To which is added an appendix shewing the way to plenty, proposed to the farmers; wherein are laid down general rules and directions for the management and improvement of a farm. Both design'd originally for the use of the several stewards and tenants of his grace the Duke of Buckingham, and now improv'd and publish'd for the general use and interest of all the nobility and gentry throughout England /

Mode of access: Internet.

Kitāb-i Nuqṭat al-kāf : dar tārīkh-i ẓuhūr-i Bāb va vaqāyiʻ-i hasht sāl-i avval az tārīkh-i Bābīyah /

Includes index.

Virginia Carolorum: the colony under the rule of Charles the First and Second, A.D. 1625-A.D. 1685 based upon manuscripts and documents of the period /

Includes index.

Substance of a speech delivered before the Judicial Committee of the Privy Council, on Monday the 17th and Tuesday the 18th of Dec., A.D. 1849 : upon an appeal in a cause of duplex querela, between the Rev. George Cornelius Gorham, ... and the Right Rev. Henry, Lord Bishop of Exeter, espondent ; with an introd. /

Mode of access: Internet.

The prayer book interleaved : with historical illustrations and explanatory notes arranged parallel to the text /

Added t.p.: The book of common prayer ... according to the use of the United Church of England and Ireland ... Cambridge : C.J. Clay, 1866.

UM Men's Swimming Team, 1958, diving team

Front Row: John C. Smith, Theodore C. Reissing, Richard D. Hanley, Cyrus C. Hopkins, Anthony Tashnick, Carl T. Woolley, Peter H. Fries

Middle Row: Thomas W. Prunk, M. Allen Maten, Jr., Myril Kaplan, Brian L. Browne, Edward R. Pongracz, Jim Tanner, E. Lee Fitzhugh.

Back Row: diving coach Bruce Harlan, head coach Gus Stager, manager Ray Haselby, Tony A. Turner, Edward W. Cole, Richard J. Kimball, Alvaro Gaxiola, Theodore Pong.

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of > 10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.

Structural characterization of angiotensin I-converting enzyme in complex with a selenium analogue of captopril

Human somatic angiotensin I-converting enzyme (ACE), a zinc-dependent dipeptidyl carboxypeptidase, is central to the regulation of the renin-angiotensin aldosterone system. It is a well-known target for combating hypertension and related cardiovascular diseases. In a recent study by Bhuyan and Mugesh [Org. Biomol. Chem. (2011) 9, 1356-1365], it was shown that the selenium analogues of captopril (a well-known clinical inhibitor of ACE) not only inhibit ACE, but also protect against peroxynitrite-mediated nitration of peptides and proteins. Here, we report the crystal structures of human testis ACE (tACE) and a homologue of ACE, known as AnCE, from Drosophila melanogaster in complex with the most promising selenium analogue of captopril (SeCap) determined at 2.4 and 2.35 angstrom resolution, respectively. The inhibitor binds at the active site of tACE and AnCE in an analogous fashion to that observed for captopril and provide the first examples of a protein-selenolate interaction. These new structures of tACE-SeCap and AnCE-SeCap inhibitor complexes presented here provide important information for further exploration of zinc coordinating selenium-based ACE inhibitor pharmacophores with significant antioxidant activity.