Brian Laver at LBJ demonstration

Brian Laver speaking at the demonstration to protest the visit of President Lyndon Johnson to Brisbane during the Vietnam War in January 1966. Jack Sherrington can be seen on extreme right of photograph.

Tradução do glossário da obra "Revising and editing for translators" de Brian Mossop

Brian Robert Mossop nasceu a 9 de Março de 1946 em Londres, Inglaterra, mas vive actualmente no Canadá, onde é tradutor profissional a tempo inteiro; ensina tradução a tempo parcial, dirige oficinas sobre desenvolvimento profissional e escreve sobre Tradução.

The early ceramics of the Inca heartland / Brian S. Bauer.

n.s. no.31(1999)

Marques de biblioteca: Robert Brian Tate

Explicació del motius que Robert Brian Tate podia tenir per a triar l’humanista quatrecentista Joan Margarit i Pau com a figura del seu ex-libris

egr-4, a target of EGFR signaling, is required for the formation of the brian primordial and head regeneration in planarians

During the regeneration of freshwater planarians, polarity and patterning programs play essential roles in determining whether a head or a tail regenerates at anterior or posterior-facing wounds. This decision is made very soon after amputation. The pivotal role of the Wnt/β-catenin and Hh signaling pathways in re-establishing anterior-posterior (AP) polarity has been well documented. However, the mechanisms that control the growth and differentiation of the blastema in accordance with its AP identity are less well understood. Previous studies have described a role of Smed-egfr-3, a planarian epidermal growth factor receptor, in blastema growth and differentiation. Here, we identify Smed-egr-4, a zinc-finger transcription factor belonging to the early growth response gene family, as a putative downstream target of Smed-egfr-3. Smed-egr-4 is mainly expressed in the central nervous system and its silencing inhibits anterior regeneration without affecting the regeneration of posterior regions. Single and combinatorial RNA interference to target different elements of the Wnt/β-catenin pathway, together with expression analysis of brain- and anterior-specific markers, revealed that Smed-egr-4: (1) is expressed in two phases - an early Smed-egfr-3-independent phase and a late Smed-egfr-3-dependent phase; (2) is necessary for the differentiation of the brain primordia in the early stages of regeneration; and (3) that it appears to antagonize the activity of the Wnt/β-catenin pathway to allow head regeneration. These results suggest that a conserved EGFR/egr pathway plays an important role in cell differentiation during planarian regeneration and indicate an association between early brain differentiation and the proper progression of head regeneration.

Nota preliminar sobre uma particularidade da biologia de Sardinella aurita Cuv. & Val., da costa brasileira

Na região de São Sebastião e canal do mesmo nome foi capturado um lote de larvas e alevinos de Sardinella aurita Cuv. & Val.. Esse lote compunha-se de três séries, cada qual proveniente de uma coleta diferente e oriunda do mesmo engenho de captura. O lote compunha-se de espécimes providos de portes muito diferentes, variando de 22 mm., a 105 mm.. Após as medições (em milímetros) os diagramas de variabilidade revelaram a existência de numerosos ápices (cerca de 20) que se revelaram confusos e ilegíveis. Depois de se ter tentado várias operações, conseguiu-se separar cinco curvas mais ou menos razoáveis. A pesquisa levada a efeito nessas curvas de variabilidade, não teve outro objetivo sinão o de procurar uma explicação para o conjunto dos diagramas obtidos. A existência de várias curvas prova que nos encontramos em presença de uma série de posturas consecutivas.

Families of the traumatically brian-injured : a case study approach to perceptions of quality of service, degree of satisfaction, and family needs /

The purpose of this qualitative research study was to foster an understanding of the rehabilitation counselling practice offamilies of the brain-injured. Specifically, the study explores the perceptions of stakeholders in regards to the degree of satisfaction with the quality of service received. Questionnaires were administered, and semi-structured, openended interviews were conducted, with six participating families (n=8). Preliminary data were collected via two instruments: (i) the Family Participant Questionnaire, consisting of participants' sample characteristics, information pertaining to the history of the family, details of the injury, and information relating to the type, use, and need offamily services utilized; and (ii) the Community Integration Questionnaire, a measurement of the degree of social displacementllevel of community integration of the injured family member. Utilizing the procedural steps outlined by Colaizzi's (1978) method of protocol analysis, recommendations for a future program based on related and current family needs are discussed in detail. Substantiating and supporting information are offered to rehabilitation practitioners, educational planners, and policymakers alike, concerning the degree of satisfaction with rehabilitative service, and the means of improving upon the overall quality of health care to families of the brain-injured. Implications for clinical practice and research are also raised for discussion.