955 resultados para Bogue family ( William Bogue, d. 1720 or 1)
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Includes index.
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Three distinct coordination complexes, viz., [Co(imi)(2)(tmb)(2)] (1) [where imi = imidazole], {[Ni(tmb)(2)(H2O)(3)]center dot 2H(2)O}(n) (2) and [Cu-2(mu-tmb)(4)(CH3OH)(2)] (3), have been synthesized hydrothermally by the reactions of metal acetates,2,4,6-trimethylbenzoic acid (Htmb) and with or without appropriate amine. The Ni analogue of 1 and the Co analogue of 2 have also been synthesized. X-ray single-crystal diffraction suggests that complex 1 represents discrete mononuclear species and complex 2 represents a 1D chain coordination polymer in which the Ni(H) ions are connected by the bridging water molecules. Complex 3 represents a neutral dinuclear complex. In 1, the central metal ions are associated by the carboxylate moiety and imidazole ligands, whereas the central metal atom is coordinated to the carboxylate moiety and the respective solvent molecules in 2 and 3. In 3, the four 2,4,6-trimethylbenzoate moieties act as a bridge connecting two copper (11) ions and the 0 atoms of methanol coord geometry, with the methanol molecule at the apical position. In all the three structures the central metal atom sits on a crystallographic inversion centre. In all the cases, the coordination entities are further organized via hydrogen bonding interactions to generate multifarious supramolecular networks. Complexes 1, 2 and 3 have also been characterized by spectroscopic (UV/Vis and IR) and thermal analysis (TGA). In addition, the complexes were found to exhibit antimicrobial activity. The magnetic susceptibility measurements, measured from 8 to 300 K, revealed antiferromagnetic interactions between the Co(II) ions in compound 1 and the Ni(II) ions in la, respectively.
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Mammalian heparanase is an endo--glucuronidase associated with cell invasion in cancer metastasis, angiogenesis and inflammation. Heparanase cleaves heparan sulfate proteoglycans in the extracellular matrix and basement membrane, releasing heparin/heparan sulfate oligosaccharides of appreciable size. This in turn causes the release of growth factors, which accelerate tumor growth and metastasis. Heparanase has two glycosaminoglycan-binding domains; however, no three-dimensional structure information is available for human heparanase that can provide insights into how the two domains interact to degrade heparin fragments. We have constructed a new homology model of heparanase that takes into account the most recent structural and bioinformatics data available. Heparin analogs and glycosaminoglycan mimetics were computationally docked into the active site with energetically stable ring conformations and their interaction energies were compared. The resulting docked structures were used to propose a model for substrates and conformer selectivity based on the dimensions of the active site. The docking of substrates and inhibitors indicates the existence of a large binding site extending at least two saccharide units beyond the cleavage site (toward the nonreducing end) and at least three saccharides toward the reducing end (toward heparin-binding site 2). The docking of substrates suggests that heparanase recognizes the N-sulfated and O-sulfated glucosamines at subsite +1 and glucuronic acid at the cleavage site, whereas in the absence of 6-O-sulfation in glucosamine, glucuronic acid is docked at subsite +2. These findings will help us to focus on the rational design of heparanase-inhibiting molecules for anticancer drug development by targeting the two heparin/heparan sulfate recognition domains.
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The present study aimed to investigate the effects of cytochalasin B (20 M) on the uptake of 3-O-[(14)C]-methyl-D-glucose or D-[U-(14)C]glucose (8.3 mM each) by BRIN-BD11 cells. Taking into account the distribution space of tritiated water ((3)HOH), which was unexpectedly increased shortly after exposure of the cells to cytochalasin B and then progressively returned to its control values, and that of L-[1-(14)C]glucose, used as an extracellular marker, it was demonstrated that cytochalasin B caused a modest, but significant inhibition of the uptake of D-glucose and its non-metabolized analog by the BRIN-BD11 cells. These findings resemble those observed in acinar or ductal cells of the rat submaxillary gland and displayed a relative magnitude comparable to that found for the inhibition of D-glucose metabolism by cytochalasin B in purified pancreatic islet B cells. These findings reinforce the view that the primary site of action of cytochalasin B is located at the level of the plasma membrane.
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La tagatose-1,6-biphosphate aldolase de Streptococcus pyogenes est une aldolase de classe I qui fait montre d'un remarquable manque de spcificit vis vis de ses substrats. En effet, elle catalyse le clivage rversible du tagatose-1,6-biphosphate (TBP), mais galement du fructose-1,6-biphosphate (FBP), du sorbose-1,6-biphosphate et du psicose-1,6-biphosphate, quatre stroisomres, en dihydroxyactone phosphate (DHAP) et en glycraldhyde-3-phosphate (G3P). Afin de mettre jour les caractristiques du mcanisme enzymatique, une tude structurale de la TBP aldolase de S. pyogenes, un pathogne humain extrmement versatile, a t entreprise. Elle a permis la rsolution de la structure native et en complexe avec le DHAP, a respectivement 1.87 et 1.92 de rsolution. Ces mmes structures ont permis de se reprsenter plus clairement le site actif de l'enzyme en gnral, et les rsidus catalytiques en particulier. Le trempage des cristaux de TBP aldolase dans une solution saturante de DHAP a en outre permis de piger un authentique intermdiaire iminium, ainsi que sa gomtrie particulire en atteste. Des expriences d'change de proton, entreprises afin d'valuer le stroisomrisme du transfert de proton catalytique, ont galement permis de faire une intressante dcouverte : la TBP aldolase ne peut dprotoner le cot pro-R du C3 du DHAP, mais peut le protonner. Ce rsultat, ainsi que la comparaison de la structure du complexe TBP aldolase-DHAP avec la structure du complexe FBP aldolase de muscle de lapin- DHAP, pointe vers un isomrisme cis-trans autour du lien C2-C3 de la base de Schiff forme avec le DHAP. De plus, la rsolution de ces deux structures a permis de mettre en vidence trois rgions trs mobiles de la protine, ce qui pourrait tre reli au rle postul de son isozyme chez S. pyogenes dans la rgulation de lexpression gntique et de la virulence de la bactrie. La cristallographie par rayons X et la cintique enzymatique ont ainsi permis d'avancer dans l'lucidation du mcanisme et des proprits structurales de cette enzyme aux caractristiques particulires.
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La partie cration de ce mmoire se veut soutenue par une tension narrative relie la curiosit suscite par le personnage principal, de prime abord nigmatique, qui se dvoile de faon capricieuse par un changement constant de focalisation et de temporalit. Nathan vit une re o lhumanit a frl lextinction, et o tout est repenser aprs lannihilation du virus ramenant les morts la vie. Nayant pas t tmoin de ces horreurs, ses plus grandes proccupations concernent son cheminement vers lauthenticit. Saltimbanque de mtier, il voyage de communaut en communaut, o chacune a fait ses choix pour recrer le monde. Sa volont de prner lart dans un processus de reconstruction sociale et sa poursuite dune image perdue le pousseront toujours plus loin dans ses prgrinations; vers des ralits qui le conduiront redfinir son univers. La partie essai sinterroge sur les procds formant la tension narrative des romans dmile Ajar, pseudonyme laissant deviner la plume exprimente de Romain Gary qui se rinvente dans lanonymat. Lattention est centre sur les jeux de narration, le rle actanciel des personnages et lorchestration formelle des rcits, savoir sils sont assez similaires pour lier les opus et les constituer en une srie unifie. Cette rflexion la recherche de lessence de loeuvre ajarienne, touchante par ses antihros souvent dmunis dans leur qute existentielle, a t une inspiration pour la rdaction de Le jour o la Terre en avait vu dautres. Les rves de Nathan sont raconts la premire personne, rejoignant certaines modalits ajariennes o la psych des protagonistes se rvle par une narration au je. Les questionnements sur la tension narrative ont t dclencheurs de cette premire dmarche dcriture romanesque, mme si elle est situe dans un cadre compltement autre et use dune plume bien diffrente de celle dAjar.
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Entire issue (large pdf file) Articles include: Improving Family Functioning through Family Preservation Services: Results of the Los Angeles Experiment. Family Preservation Journal. William Meezan and Jacquelyn McCroskey Idiographic Self-Monitoring Instruments to Empower Client Participation and Evaluate Outcome in Intensive Family Preservation Services. Barbara Peo Early Evaluating Family Preservation in Nevada: A University-State Agency Collaboration. Christine Bitoni and Joy Salmon The Family Partners Credit Card: A Token Economy System Adapted for Intensive Family Preservation Services to Enable Families to Manage Difficult Behavior of Adolescents. Jude Nichols and Barbara Peo Early Toward the Development of Ethical Guidelines for Family Preservation. David A Dosser Jr., Richard J. Shaffer, Michaux M. Shaffer, DeVault Clevenger, and Dustin K. Jefferies
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"Bibliography, compiled b Alice G. Waters": v. 1, p. xxxvii-x1.
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Mode of access: Internet.
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Vols. 2-7 were also published separately.
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I-VI. The divine legation of Moses demonstrated.--VII. The alliance between church and state.--VIII. Julian. The doctrine of grace.--IX. The principles of natural and revealed religion.--X. Sermons on various subjects and occasions.--XI-XII. Controversial tracts.
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Mode of access: Internet.
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Index at end of each volume: Classified subject index to the set at end of v. 4.
