Secure modular password authentication for the web using channel bindings

Secure protocols for password-based user authentication are well-studied in the cryptographic literature but have failed to see wide-spread adoption on the Internet; most proposals to date require extensive modifications to the Transport Layer Security (TLS) protocol, making deployment challenging. Recently, a few modular designs have been proposed in which a cryptographically secure password-based mutual authentication protocol is run inside a confidential (but not necessarily authenticated) channel such as TLS; the password protocol is bound to the established channel to prevent active attacks. Such protocols are useful in practice for a variety of reasons: security no longer relies on users' ability to validate server certificates and can potentially be implemented with no modifications to the secure channel protocol library. We provide a systematic study of such authentication protocols. Building on recent advances in modelling TLS, we give a formal definition of the intended security goal, which we call password-authenticated and confidential channel establishment (PACCE). We show generically that combining a secure channel protocol, such as TLS, with a password authentication protocol, where the two protocols are bound together using either the transcript of the secure channel's handshake or the server's certificate, results in a secure PACCE protocol. Our prototype based on TLS is available as a cross-platform client-side Firefox browser extension and a server-side web application which can easily be installed on deployed web browsers and servers.

Two-Dimensional Kinetics Of Beta(2)-Integrin And Icam-1 Bindings Between Neutrophils And Melanoma Cells In A Shear Flow

Cell adhesion, mediated by specific receptor-ligand interactions, plays an important role in biological processes such as tumor metastasis and inflammatory cascade. For example, interactions between beta(2)-integrin ( lymphocyte function-associated antigen-1 and/or Mac-1) on polymorphonuclear neutrophils (PMNs) and ICAM-1 on melanoma cells initiate the bindings of melanoma cells to PMNs within the tumor microenvironment in blood flow, which in turn activate PMN-melanoma cell aggregation in a near-wall region of the vascular endothelium, therefore enhancing subsequent extravasation of melanoma cells in the microcirculations. Kinetics of integrin-ligand bindings in a shear flow is the determinant of such a process, which has not been well understood. In the present study, interactions of PMNs with WM9 melanoma cells were investigated to quantify the kinetics of beta(2)-integrin and ICAM-1 bindings using a cone-plate viscometer that generates a linear shear flow combined with a two-color flow cytometry technique. Aggregation fractions exhibited a transition phase where it first increased before 60 s and then decreased with shear durations. Melanoma-PMN aggregation was also found to be inversely correlated with the shear rate. A previously developed probabilistic model was modified to predict the time dependence of aggregation fractions at different shear rates and medium viscosities. Kinetic parameters of beta(2)-integrin and ICAM-1 bindings were obtained by individual or global fittings, which were comparable to respectively published values. These findings provide new quantitative understanding of the biophysical basis of leukocyte-tumor cell interactions mediated by specific receptor-ligand interactions under shear flow conditions.

2D Kinetics and Forced Dissociation of Selectin-ligand Bindings

Cell adhesion is crucial to many pathophysiological processes, such as inflammatory reaction and tumor metastasis. It is mediated by specific interactions between receptors and ligands, and provides the physical linkages among cells. For example, interactions between selectins and glycoconjugate ligands mediate leukocyte initially tethering to and subsequently rolling on vascular surfaces in sites of inflammation or injury, which is determined by their fast kinetic rates. To mediate cell adhesion, the interacting receptors and ligands must anchor to apposing surfaces of two cells or a cell and the substratum, i.e. , the so-called two-dimensional (2D) binding, which differs from interactions in the fluid phase, i.e. , the three-dimensional (3D) binding. How structural variations and surface environments of interacting molecules affect their 2D kinetics, and how external forces manipulate their dissociation has little been known quantitatively, and nowadays attracts more and more attentions.

Effect of L-Prolyl-L-Leucyl-Glycinamide (PLG) on Neuroleptic-Induced Catalepsy and Dopamine/Neuroleptic Receptor Bindings

Effect of L-prolyl-cinagta tlheep spyo atenndt idaol paanmti-iPnaer/nkeinusroonleiapnti cp rreocpeeprttoiers b oifn dLi-npgrso.lyPl E-LP-TleIuDcEylS- g2l(y1c)Li n1-a0lem5u-ic1dy1el1-g,(Ply1Lc9iG8n1)a. mw-Taidhsee i nm(vPeeLcstGhiag) anotinesmd n ie onuf rb oaelchetapiovtinico -suuirnbadslu eacrnevddetnarflefetueeacrrtmto a coephfnp ePtrmLe(2icGc0iaa, lob4 mnl0y io atndnhedevl sii8tn r0oto fem dndgosoi ppktyaag mm o-1fii nn tSeehCr/eng cteiwcau tfiracuolenle edpcptattiiioiclcny r r feienoscrp et ohfpinetvos erer ad ebtali.iyncAsdit)cienusdgit ge bin nyai dfrhimacaatli nonsttpilrseytirar aiatdtuttoimeolnn u(a3aso tmfde PidgfL f hkeGargel -o(n'p2tI0ieaPr ali)ldn.y odB ll ay4-b 0icne omldlneugtdc rk eabgdsy t - c1,aa pcSthoaCrmleo)ponfrsaicypil .heP TidLn hteGoe pahnidn esp tior odpoepraimdoinl ew raesc aelpstoo ersx ainm tihnee dst.rPiaLtuGm s,elbeuctt ihvaedly n eon ehfafneccte don t h['eH a]ffsipniirtoyp oefr tidhoel sbpiencdifinicg .b Tinhdei nbge hoafv aigouonraislt an[3dH b] iaopcohmemori-- cal results obtained in the present study raise the possibility that PLG may facilitate nigro-striatal dopaminergic neurotransmission through interacting with a unique PLG receptor functionally coupled to the dopamine receptor cyclase complex. -adenylate

Early modern Oxford bindings in twenty-first century markup

Purpose – The Bodleian Binders Book contains nearly 150 pages of seventeenth century library records, revealing information about the binders used by the library and the thousands of bindings they produced. The purpose of this paper is to explore a pilot project to survey and record bindings information contained in the Binders Book. Design/methodology/approach – A sample size of seven pages (91 works, 65 identifiable bindings) to develop a methodology for surveying and recording bindings listed in the manuscript. To create a successful product that would be useful to bindings researchers, it addressed questions of bindings terminology and the role of the library in the knowledge creation process within the context that text encoding is changing the landscape of library functions. Text encoding formats were examined, and a basic TEI (Text Encoding Initiative) transcription was produced. This facilitates tagging of names and titles and the display of transcriptions with text images. Findings – Encoding was found not only to make the manuscript content more accessible, but to allow for the construction of new knowledge: characteristic Oxford binding traits were revealed and bindings were matched to binders. Plans for added functionality were formed. Originality/value – This research presents a “big picture” analysis of Oxford bindings as a result of text encoding and the foundation for qualitative and statistical analysis. It exemplifies the benefits of interdisciplinary methods – in this case from Digital Humanities – to enhance access to and interpretation of specialist materials and the library's provenance record.

Syntheses, receptor bindings, in vitro and in vivo stabilities and biodistributions of DOTA-neurotensin(8-13) derivatives containing β-amino acid residues - a lesson about the importance of animal experiments

Neurotensin(8-13) (NTS(8-13)) analogs with C- and/or N-terminal β-amino acid residues and three DOTA derivatives thereof have been synthesized (i.e., 1-6). A virtual docking experiment showed almost perfect fit of one of the 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) derivatives, 6a, into a crystallographically identified receptor NTSR1 (Fig.1). The affinities for the receptors of the NTS analogs and derivatives are low, when determined with cell-membrane homogenates, while, with NTSR1-exhibiting cancer tissues, affinities in the single-digit nanomolar range can be observed (Table 2). Most of the β-amino acid-containing NTS(8-13) analogs (Table 1 and Fig.2), including the (68) Ga complexes of the DOTA-substituted ones (6; Figs.2 and 5), are stable for ca. 1 h in human serum and plasma, and in murine plasma. The biodistributions of two (68) Ga complexes (of 6a and 6b) in HT29 tumor-bearing nude mice, in the absence and in the presence of a blocking compound, after 10, 30, and 60 min (Figs. 3 and 4) lead to the conclusion that the amount of specifically bound radioligand is rather low. This was confirmed by PET-imaging experiments with the tumor-bearing mice (Fig.6). Comparison of the in vitro plasma stability (after 1 h) with the ex vivo blood content (after 10-15 min) of the two (68) Ga complexes shows that they are rapidly cleaved in the animals (Fig.5).

Catalogue of the magnificent private library of the late Amor L. Hollingsworth of Milton, Mass. ... Magnificent collection of fine and rare books, many in sumptuous bindings by the finest binders in the world. Rare English and American first editions. Extra illustrated books ...

Plates partly printed on both sides.

Guide to the manuscripts, autographs, charters, seals, illuminations and bindings exhibited in the Department of Manuscripts and in the Grenville library.

Edited by George F. Warner, keeper of mss.

Early Oxford bindings;

"A contribution to the history of bookbinding at Oxford down to the period of the civil war; it treats solely of bindings decorated with stamps and rolls to the exclusion of all gilt-tooled work."

One hundred and seventy-six historic and artistic book-bindings dating from the fifteenth century to the present time pictured by etchings, artotypes, and lithographs after the originals selected from the library of Robert Hoe ...

"The edition consists of two hundred copies only, all printed upon imperial Japanese paper."

First editions of English and American authors, standard sets in fine bindings, limited editions, illustrated books, Americana, voyages and travel, a fine collection of books on art and architecture ... Property of the Southern California Group of the Antiquarian Booksellers' Association of America, to be sold at unrestricted public auction September 29, 1949 ...

295 items.

Sets of standard authors, mainly in fine bindings ... ornithological books ... American maps, extra-illustrated books ... of the estates of ... Emil Winters ... and other owners ...

Mode of access: Internet.