Reverend Ellen Barrett, first lesbian Episcopal Priest, with Reverend Paul Moore

General note: Title and date provided by Bettye Lane.

Reverend Ellen Barrett, first lesbian Episcopal Priest, with Reverend Paul Moore

General note: Title and date provided by Bettye Lane.

Reverend Ellen Barrett

General note: Title and date provided by Bettye Lane.

Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's Esophagus

Barrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to esophageal adenocarcinoma (EAC), a tumor with a very poor prognosis. We report the first genome-wide association study on Barrett's esophagus, comprising 1,852 UK cases and 5,172 UK controls in the discovery stage and 5,986 cases and 12,825 controls in the replication stage. Variants at two loci were associated with disease risk: chromosome 6p21, rs9257809 (P combined = 4.09 × 10-9; odds ratio (OR) = 1.21, 95% confidence interval (CI) =1.13-1.28), within the major histocompatibility complex locus, and chromosome 16q24, rs9936833 (P combined = 2.74 × 10-10; OR = 1.14, 95% CI = 1.10-1.19), for which the closest protein-coding gene is FOXF1, which is implicated in esophageal development and structure. We found evidence that many common variants of small effect contribute to genetic susceptibility to Barrett's esophagus and that SNP alleles predisposing to obesity also increase risk for Barrett's esophagus. © 2012 Nature America, Inc. All rights reserved.

Ellen Bernkopf nee Catzenstein pumping water outdoors; Ascona, Switzerland. Portraits Women

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Studio portrait of Ellen Bernkopf nee Catzenstein. Portraits Women

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Portrait of Ellen Bernkopf nee Catzenstein as an infant. Portraits Children

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Studio portrait of Ellen Bernkopf nee Catzenstein; Ascone, Switzerland. Portraits Women

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Outdoor portrait of Ellen Bernkopf nee Catzenstein with her husband Hans Bernkopf; Paris, France. Portraits Couples

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Profile view of bust of Henriette Gottschalk nee Rothschild by Ellen Bernkopf (Colmar) nee Catzenstein.

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Portrait of Franz Catzenstein and his little sister Ellen. Portraits Children

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Ellen Bernkopf nee Catzenstein working on a sculpture Portraits Women

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"Dancing Lady" sculpture by Ellen Bernkopf nee Catzenstein Artworks

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Sculptures by Ellen Bernkopf nee Catzenstein in the home of her daughter Yael Arnold; Waldstetten.

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Sculptures by Ellen Bernkopf nee Catzenstein Artworks

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