Phytochemical investigation of plants used in African traditional medicine: "Dioscorea sylvatica" (Dioscoreaceae), "Urginea altissima" (Liliaceae), "Jamesbrittenia fodina" and "Jamesbrittenia elegantissima" (Scrophulariaceae)

Les plantes médicinales représentent la seule source de médicaments pour près de 90 % de la population de certains pays d?Afrique. Le savoir-faire des guérisseurs traditionnels, d?une valeur inestimable, représente un point de départ pour l?investigation pharmacologique et phytochimique de ces médicaments naturels. Dans le cadre de ce travail, nous nous sommes dans un premier temps intéressés à valider l?utilisation en médecine traditionnelle de deux plantes, Diuscorea sylvatica (Dioscoreaceae) et Urginea altissima (Liliaceae), qui produisent, lorsqu?elles sont frottées sur la peau, une inflammation et des démangeaisons. Ces réactions cutanées ont pu être expliquées, au moins en partie, par la présence d?aiguilles acérées d?oxalate de calcium dans les organes souterrains. Ces microtraumatismes répétés de l?épiderme risquent de provoquer, lors d?une utilisation prolongée, des lésions granulomateuses. L?histamine n?a pas été détectée, mais d?autres substances pourraient être impliquées dans le processus inflammatoire. La seconde partie de ce travail a consisté en la détection, l?isolement et la caractérisation de nouveaux composés naturels présentant un intérêt thérapeutique potentiel. 70 extraits provenant de 28 plantes supérieures du Zimbabwe ont été soumis à un criblage chimique et biologique. Les extraits méthanoliques des parties aériennes de Jamesbrittenia fodina et J. elegantissima (Scrophulariaceae) ont été sélectionnés sur la base de leurs nombreuses activités. Le fractionnement guidé par l?activité de J. fudina a permis l?isolement des saponines A et B, responsables des activités antifongique, antibactérienne et molluscicide de l?extrait. De plus, les deux saponines ont montré une activité équivalente en tant qu?inhibiteurs de l?acétylcholinestérase, propriété encore non décrite pour cette classe de composés. Une analyse LC/uv/MS de l?extrait a permis d?attribuer l?activité antiradicalaire au verbascoside, un dérivé du phenylpropane; cette analyse a de plus montré la présence d?une série de dérivés de l?acide cinnamique, dont l?isolement a été entrepris. Deux problèmes d?instabilité sont apparus, empêchant l?isolement des composés par des méthodes chromatographiques de pointe, en dépit de très bonnes conditions de séparations. Des analyses LC/?H-NMR combinées à des analyses RMN classiques des mélanges ont permis d?attribuer ces instabilités d?une part à une isomérisation cis/trans induite par la lumière, et d?autre part à une transacylation du groupe cinnamoyl sur une unité de sucre. Ceci a permis l?identification de 12 esters cinnamiques d?iridoïdes, dont 8 nouveaux produits naturels. Ces dérivés présentent un intérêt thérapeutique, car des composés similaires ont montré des propriétés anti-inflammatoires significatives dans différents modèles in vivo. Deux flavanones ont aussi été isolées de l?extrait. Cette classe de composés n?a jamais été rapportée chez un membre des Scrophulariaceae. Une analyse LC/UV/MS comparative des extraits polaires des deux espèces, J. fodina et J. elegantissima, a été effectuée pour détecter la présence éventuelle de compos.és communs. Les saponines A et B et le verbascoside ont été identifiés dans l?extrait de J. elegantissima. Trois flavonoïdes ont de plus été isolés de ce dernier par CPC et HPLC semi-préparative.<br/><br/>In certain African countries, medicinal plants represent the unique source of to 90% of the population. The knowledge of traditional healers represents a basis for the pharmacological and phytochemical investigation of these natural medicines. This work first focused on the validation of use of two plants frequently employed in traditional medicine, Dioscorea sylvatica (Dioscoreaceae) and Urginea altissimu (Liliaceae), which produce mild inflammation and itching when rubbed on the skin. These cutaneous reactions were shown to be due, at least in part, to the presence of sharp needles of calcium oxalate, implying the risk of granulomatous lesions following a long term use. Histamine was not detected, but other compounds could be involved in the inflammatory process. The second part of this work consisted of the detection, isolation and characterisation of new natural compounds of potential therapeutic interest from African plants. Seventy extracts obtained from 28 higher plants of Zimbabwe were submitted to a chemical and biological screening. The methanol extracts of the whole plants of Jamesbrittenia fodina and J. elegantissima (Scrophulariaceae) were selected for their various activities. An activity-guided fractionation of J. fodina led to the isolation of the saponins A and B, responsible for the antifungal, antibacterial and molluscicidal properties. Both saponins were equally active as inhibitors of acetylcholinesterase, a property that has, to our knowledge, never been described for this class of compounds. A LC/UV/MS analysis of the extract allowed the identification of verbascoside as the product with radical scavenging activity, and indicated the presence of a series of potentially interesting cinnamic acid derivatives. Two types of instability problems occurred in the course of their isolation, as some compounds could not be separated despite very good chromatographic conditions. LC/'H-NMR analyses combined with in-mixture NMR analyses enabled the attribution of the cause of the instability in one case to a cidtrans light-induced isomerisation, and in the other case to a transacylation of the cinnamoyl moiety on a sugar residue. These problems of instability have not been the object of previous studies. 12 cinnamic iridoid esters could be characterised, 8 of these being new natural compounds. Several similar substances have displayed significant anti-inflammatory properties in different in vivo models, suggesting a therapeutic interest for these new derivatives. Two flavanones were isolated from the same extract. This class of compound has not been previously reported from species of the Scrophulariaceae family. A comparative LCAJVNS study of the polar extracts of the two species J. elegantissima and J. fodina was performed in order to detect possible common compounds. Saponins A and B and verbascoside were thus identified in .J. elegantissima. Moreover, three supplementary flavonoids were isolated from J. elegantissima..

Pour un modèle chrétien de réconciliation dans la société luba : une interprétation des pratiques traditionnelles luba de réconciliation à partir de Genèse 32–33 et une proposition d’appropriation chrétienne contemporaine

Pour des raisons de limitation, cette thèse analyse le thème de la réconciliation à partir des pratiques traditionnelles des Baluba du Katanga; elle concerne et s'applique également aux autres ethnies bantu en Afrique Centrale où ces pratiques sont similaires.

Représentations des religions traditionnelles africaines : analyse comparative de réseaux régionaux et disciplinaires africains et occidentaux

Ce mémoire présente une réflexion critique sur différentes représentations des religions traditionnelles africaines (RTA) au sein de réseaux régionaux et disciplinaires africains et occidentaux. Dans un premier temps, plusieurs formes de représentations (cartographiques et graphiques) issues de milieux universitaires occidentaux sont explorées pour comparer le traitement des RTA. Cette exploration soulève le problème des catégorisations employées qui ne rendent pas compte de la diversité, du dynamisme, de la complexité et de l’importance des RTA; et de manière plus générale, cette analyse révèle un problème sur le plan de l’équité dans les représentations des religions du monde. À l’aide d’une analyse conceptuelle, un certain nombre de catégories utilisées pour définir les RTA, notamment celle de « religion ethnique », sont remises en question, tout comme la notion de religion du monde (world religion). Dans un deuxième temps, les stratégies de recherche utilisées pour retracer des réseaux de chercheurs africains sont présentées. Différents outils et ressources documentaires occidentaux sont analysés et évalués selon qu’ils donnent accès ou non à la production de chercheurs africains sur les RTA. L’analyse de ces documents, laquelle est inspirée d’une démarche d’analyse de discours, révèle à quel point la contribution des chercheurs africains est peu prise en compte à l’intérieur du corpus sélectionné. Or, l’exploration de la situation actuelle de l’enseignement et de la recherche sur les RTA dans certaines universités du Nigéria met en lumière la somme importante de travaux sur les RTA et la diversité des canaux de communication. En somme, ce mémoire démontre à quel point le savoir est localisé et lié aux ancrages culturels, disciplinaires et idéologiques des chercheurs. Il ouvre, à partir de l’analyse de textes africains, sur la question plus large de la difficulté de la représentation de l’unité et des particularismes des RTA.

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The paper engages the question of how traditional religion persist in an increasingly problematic and complex swiss context. In particular, the chapter looks at the phenomenon of charismatic worship as a vehicle for resignifying the meaning of chronic suffering, over and against the traditional evangelical expectation that worldly hardship is but a temporary trial, to be endured and overcome by true believers. The experience of ongoing physical and psychological suffering is mediated by ritualized narratives, which resituate the afflicted "stakeholders" as important models of Christian life. In so doing, these narratives richly dramatize the resolution of theodicy by showing that, far from being absent in the lives of sufferers, God is especially present.

Écoles catholiques et diversité religieuse en classe : cas du Collège catholique Père Aupiais de Cotonou en République du Bénin

Résumé La diversité religieuse est un fait bien attesté aujourd’hui en République du Bénin. Chrétiens, Musulmans, adeptes des religions traditionnelles et ceux d'autres spiritualités se côtoient autant dans la sphère publique que privée sur le territoire béninois. N’épargnant donc aucun domaine de la société béninoise, cette diversité s'exprime également dans les milieux scolaires notamment dans les écoles privées catholiques du pays. La volonté du diocèse de Cotonou d'ouvrir les portes de ses écoles à tous les enfants sans distinction de religions ni d'ethnies, entraine de facto l'épineux problème de la gestion de la diversité religieuse et du pluralisme dans ses institutions confessionnelles. Sensible à cette problématique en milieu scolaire auprès des jeunes, le cas du collège catholique Père Aupiais nous intéresse pour son approche du cours de religion dispensé aux élèves du premier cycle. Le présent travail dans une démarche praxéologique, observe, analyse et interprète un cours confessionnel de religion donné en classe de 5è secondaire dans ledit collège. Cette interprétation s’appuie sur des référents théoriques que sont le Magistère de l'Église, un texte biblique, l’approche pédagogique de Philippe Meirieu, la théologie dialogale de Richard Bergeron, l’apport de certains responsables d'écoles privées confessionnelles québécoises. Ces derniers constituent des éléments importants dans notre intervention dans le contexte de ce travail. Il s’agit en définitive de proposer quelques recommandations pour la mise en place d'un cours d'enseignement moral et religieux favorisant le « vivre ensemble ». L’intérêt de ce travail est de susciter le débat sur la gestion de la diversité et du pluralisme en milieu scolaire catholique béninois.

Movies, Mind and Meaning : Studying Audience and Favourite Films

Construction of identity and meaning is becoming increasingly important in both media studies and religion scholarship. (Lövheim, 2004) Meaning construction outside traditional religion has become more interesting for religious studies and what individuals in the audience do with all messages circulated through media in everyday life has attended increasing interest within media studies (Stout and Buddenbaum, 2001). Motion pictures, soap operas and advertising are all examples of media contents which generate ideas among its audience which to a various degree are used as resources within the construction of identity (Jansson, 2001). The investigation of what modern humankind’s world views look like and what components they are composed of, in this context seems to be an important topic of investigation (Holm and Björkqvist, 1996). The ways in which the development of media has effected the daily lives of individuals is interest as is the nature of the self and the ways in which the process of self-formation is affected by the profusion of mediated materials (Thompson, 1995). Film and religion are my interest within this larger frame. The topic is not exactly new but the combination of film and religion has during the last ten years resulted in a rapidly growing number of books by scholars interested in this field (Lyden, 2003). One growing focus is on the role that films can and do play within the emerging and developing valuesystem of people in the West today (Marsh, 2004). The British theologian Clive Marsh’s point of departure is very similar to my own. Viewers bring to a film life-experience, immediate concerns and worldviews and the exploration of this interplay between movies and the interpreting process of meaning making is the very focus in this paper. Theoretically, the semeiological model of Alf Linderman is combined with cultural cognitive approaches used by a number of Scandinavian media scholars developing perspectives in audience theory (Linderman, 1996, Höijer and Werner, 1998). 13 individuals, their favourite movie and what it means to them in their life My aim is to examine how individuals comprehend film and what the meaning process look like. In this paper I present the outcome of 13 interviews with young people about their favourite film. I suggest how it is possible to interpret how they interrelate film comprehension with their personal beliefs and their culturally constructed worldview from a sociocognitive point of view. Examples of films chosen range from Disneys Lion King (1994), sciencefiction and fantasy successes like The Matrix (1999) and Lord of the Rings (2001) or the next best movie ever according to www.IMdb.com The Shawshank Redemption (1994) as well as the Swedish blockbuster Så som i himmelen (2004), aka “As in Heaven”.

A Cabana Umbamdista Pai Joaquim de Angola: frente a intolerância a Umbanda na Cidade do Natal/RN

This dissertation presents an attempt to register the initial steps of african-Brazilian religion Umbanda in the city of Natal, capital of Rio Grande do Norte, from a case study of Cabana Umbanda Pai Joaquim de Angola, represented by its maintainer, umbanda of the priest José Clementino. The main objective is to record the memories of fans in aspects of its tradition, experience social and cultural religious building, in an attempt to show the religious hatred with practitioners of Umbanda. Used to: in audio recordings of festivals and rituals, narratives about the memories and stories of employees and their explanations, photographs, diary entries in the field, participant observation and interviews available. The analysis referred to in umbanda Natal / RN, was based on field research as a product of the visits that took place between the years 2006 to 2009 in Terreiro de Umbanda Pai Joaquim de Angola, located in the neighborhood of Rocas.

Anti-nociceptive effects of Carpolobia lutea G. Don (Polygalaceae) leaf fractions in animal models

Leaves from Carpolobia lutea (Polygalaceae) were screened to establish the antiulcer ethnomedicinal claim and to quantitatively isolate, elucidate the active compounds by semi-preparative HPLC. The anti-nociceptive effects of Carpolobia lutea (CL) G. Don (Polygalaceae) organic leaf extracts were tested in experimental models in mice. The anti-nociceptive mechanism was determined using tail-flick test, acetic acid-induced abdominal constrictions, formalin-induced hind paw licking and the hot plate test. The fractions (ethanol, ethyl acetate, chloroform, n-hexane) and crude ethyl acetate extract of CL (770 mg/kg, i.p.) produced significant inhibitions of both phases of the formalin-induced pain in mice, a reduction in acetic acid-induced writhing as well as and an elevation of the pain threshold in the hot plate test in mice. The inhibitions were greater to those produced by indomethacin (5 mg/kg, i.p.). Ethyl acetate fraction revealed cinnamic and coumaric acids derivatives, which are described for the first time in literature. These cinnamalglucosides polyphenols characterised from CL may in part account for the pharmacological activities. These findings confirm its ethnomedical use in anti-inflammatory pain and in pains from gastric ulcer-associated symptoms. © 2011 Springer Basel AG.

Casamentos entre Católicos Romanos e Judeus: desafios de conviver com diferentes tradições religiosas e o de orientar os filhos na sua formação espiritual.

Esta pesquisa tem como objetivo observar o casamento inter-religioso. O encontro de duas culturas religiosas pode e, provavelmente, constituirá fonte de conflito. Os conflitos emergentes podem ocorrer, não por uma visão diferente de mundo, mas essencialmente porque o outro, por ser diferente, ameaça a identidade do indivíduo. Frente à ameaça, é necessário fortalecer a própria identidade. A partir de entrevistas com seis casais em casamentos inter-religiosos, mais especificamente, entre cristãos e judeus, e com filhos com idade entre zero e cinco anos e entre quatorze e vinte e quatro anos de idade, residentes em São Paulo, Capital, pretendi analisar como os casais lidam com os desafios que surgem quando um cônjuge pertence a uma tradição religiosa diferente da do outro. Dentre os desafios, está o de lidar com a educação religiosa ou a formação espiritual de seus filhos. Utilizando-se como referencial a Terapia Sistêmica Familiar, principalmente o trabalho de Paul Watzlawick sobre a comunicação e o de Murray Bowen sobre o funcionamento humano dentro dos sistemas familiares, além de outros referenciais auxiliares para trabalhar a questão intercultural no casamento, pretendi discutir as implicações para a práxis religiosa e oferecer contribuições à clínica psicológica e às ciências da religião. A psicologia necessita repensar sua prática, deixando o preconceito em relação à religião de lado e incluindo essa em seus estudos, de modo a aproximar o discurso e a prática do terapeuta, uma vez que pode tomar consciência de seus próprios valores religiosos quando buscar compreender a religião e a espiritualidade de sua clientela. Por sua vez, as instituições religiosas necessitam refletir sobre sua práxis, de modo a alcançar as famílias que se encontram na periferia das religiões. Famílias que solicitam uma orientação, uma formação religiosa, mas que, sendo inter-religiosas, necessitam ser reconhecidas e respeitadas como tal. Portanto, as igrejas precisam abrir-se, deixar de olhar para dentro de si mesmas e servir ao mundo, mesmo que parte desse mundo nunca venha a se tornar formalmente membro da comunidade.(AU)

Magic City Gospel

Magic City Gospel is a collection of poems that explores themes of race and identity with a special focus on racism in the American South. Many of the poems deal directly with the author’s upbringing in Birmingham, Alabama, the Magic City, and the ways in which the history of that geographical place informs the present. Magic City Gospel confronts race and identity through pop culture, history, and the author’s personal experiences as a black, Alabama-born woman. Magic City Gospel is, in part, influenced by the biting, but softly rendered truth and historical commentary of Lucille Clifton, the laid-back and inventive poetry of Terrance Hayes, the biting and unapologetically feminist poetry of Audre Lorde, and the syncopated, exact, musical poetry of Kevin Young. These and other authors like Tim Siebles, Gwendolyn Brooks, and Major Jackson influence poems as they approach the complicated racial and national identity of the author.

Playing Miami : Afrocuban performance artists negotiating cubanidad

The social scripts that are deeply involved in cultural production by AfroCuban identified artists in Miami, during the late nineties to the present, participate in a climate that is informed by and feeds from the so-called Latin Explosion of this time period. More specifically, varying historical, socioeconomic, and geopolitical trajectories have placed Africa and African-based religion and cultural production (via music and theatre) at the center of Cuban national identity. The purpose of this study is to facilitate a discussion of the experiences of AfroCuban performance artists and the climate for production, given the aforementioned dynamics, in mass media. These experiences are directed by a study of transnational structures for cultural production (including the more recent memory-shadow of hip-hop culture in Cuba) and discourse that engages theories of modernity, authenticity, and resistance. Through the interventions of artists, producers, and distributors via their art and business, the text identifies and resists the pervasive oppression of stereotype, dehumanization (Othering), and essentialism.

Transnational Migrants and Transnational Spirits: An African Religion in Lisbon

Journal of Ethnic and Migration Studies, Vol.34, n.2,pp. 253 — 269

Risk of cardiovascular disease in a traditional African population with a high infectious load: a population-based study.

BACKGROUND: To test the inflammatory origin of cardiovascular disease, as opposed to its origin in western lifestyle. Population-based assessment of the prevalences of cardiovascular risk factors and cardiovascular disease in an inflammation-prone African population, including electrocardiography and ankle-arm index measurement. Comparison with known prevalences in American and European societies. METHODOLOGY/PRINCIPAL FINDINGS: Traditional population in rural Ghana, characterised by adverse environmental conditions and a high infectious load. Population-based sample of 924 individuals aged 50 years and older. Median values for cardiovascular risk factors, including waist circumference, BMI, blood pressure, and markers of glucose and lipid metabolism and inflammation. Prevalence of myocardial infarction detected by electrocardiography and prevalence of peripheral arterial disease detected by ankle-arm index. When compared to western societies, we found the Ghanaians to have more proinflammatory profiles and less cardiovascular risk factors, including obesity, dysglycaemia, dyslipidaemia, and hypertension. Prevalences of cardiovascular disease were also lower. Definite myocardial infarction was present in 1.2% (95%CI: 0.6 to 2.4%). Peripheral arterial disease was present in 2.8% (95%CI: 1.9 to 4.1%). CONCLUSIONS/SIGNIFICANCE: Taken together, our data indicate that for the pathogenesis of cardiovascular disease inflammatory processes alone do not suffice and additional factors, probably lifestyle-related, are mandatory.

Use of modern and traditional products to self-treat symptoms of sexually transmitted infections in South African women

The objective of the study is to investigate products used by women self-treating symptoms of reproductive tract infections (RTIs), including sexually transmitted infections (STIs), and their methods of administration. A household survey using a multi-stage cluster sample design was undertaken in KwaZulu-Natal, South Africa. Women aged 18-60 years were interviewed (n = 867) and information was collected on demographics, reproductive health and sexual behaviours. A fifth of women reported having RTI/STI symptoms (20.5%), of whom 41.9% were treating these symptoms (mostly discharge [79.1%], ulcers [6.8%] and itching [7.7%]). Only three women were using medication prescribed by a health provider, while the remainder were self-treating using traditional medicines and modern products, including antiseptics, soaps, petroleum jelly, menthol creams and alum. Products were administered in various ways. Although RTI/STI treatment is widely available and free in public health facilities, many women are still self-treating. Potential harm of products for self-treatment requires further investigation and efforts should be made to improve STI service uptake.