Genomewide Linkage Scan of 409 European-ancestry and African American Families with Schizophrenia: Suggestive Evidence of Linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the Combined Sample

We report the clinical characteristics of a schizophrenia sample of 409 pedigrees-263 of European ancestry ( EA) and 146 of African American ancestry ( AA)-together with the results of a genome scan ( with a simple tandem repeat polymorphism interval of 9 cM) and follow-up fine mapping. A family was required to have a proband with schizophrenia ( SZ) and one or more siblings of the proband with SZ or schizoaffective disorder. Linkage analyses included 403 independent full-sibling affected sibling pairs ( ASPs) ( 279 EA and 124 AA) and 100 all-possible half-sibling ASPs ( 15 EA and 85 AA). Nonparametric multipoint linkage analysis of all families detected two regions with suggestive evidence of linkage at 8p23.3-q12 and 11p11.2-q22.3 ( empirical Z likelihood-ratio score [ Z(lr)] threshold >= 2.65) and, in exploratory analyses, two other regions at 4p16.1-p15.32 in AA families and at 5p14.3-q11.2 in EA families. The most significant linkage peak was in chromosome 8p; its signal was mainly driven by the EA families. Z(lr) scores >= 2.0 in 8p were observed from 30.7 cM to 61.7 cM ( Center for Inherited Disease Research map locations). The maximum evidence in the full sample was a multipoint Z(lr) of 3.25 ( equivalent Kong-Cox LOD of 2.30) near D8S1771 ( at 52 cM); there appeared to be two peaks, both telomeric to neuregulin 1 ( NRG1). There is a paracentric inversion common in EA individuals within this region, the effect of which on the linkage evidence remains unknown in this and in other previously analyzed samples. Fine mapping of 8p did not significantly alter the significance or length of the peak. We also performed fine mapping of 4p16.3-p15.2, 5p15.2-q13.3, 10p15.3-p14, 10q25.3-q26.3, and 11p13-q23.3. The highest increase in Z(lr) scores was observed for 5p14.1-q12.1, where the maximum Z(lr) increased from 2.77 initially to 3.80 after fine mapping in the EA families.

The perception of the African-American community through the eyes of the Hispanic media in the U.S.: a critical discourse analysis of the reporting of the death of Michael Brown

In this paper, 36 English and 38 Spanish news articles were selected from English and Spanish newspapers and magazines published in the U.S.A. from August 2014 to November 2014. All articles discuss the death of Michael Brown, the ensuing protests and police investigations. A discourse analysis shows that there are few differences between reporting by the mainstream and the Hispanic media. Like the mainstream media, the Hispanic media adopts a neutral point of view with regard to the African-American minority. However, it presents a negative opinion with regard to the police. It appears that the Hispanic media does not explicitly side with the African-American community, but rather agrees more with the mainstream media’s opinion and is substantially influenced by it.

The Iowa African-American Journal, July 1999, Vol. 5, no. 3

Newsletter for the Iowa Commission on the Status of African-Americans

The Iowa African-American Journal, January 2000, Vol. 6, no. 1

Newsletter for the Iowa Commission on the Status of African-Americans

The Iowa African-American Journal, July 2000, Vol. 6, no. 2

Newsletter for the Iowa Commission on the Status of African-Americans

The Iowa African-American Journal, November 2000, Vol. 6, no. 3

Newsletter for the Iowa Commission on the Status of African-Americans

The Iowa African-American Journal, Spring/Fall 2001, Vol. 7, no. 1

Newsletter for the Iowa Commission on the Status of African-Americans

The Iowa African-American Journal, Spring/Fall 2002, Vol. 8, no. 1

Newsletter for the Iowa Commission on the Status of African-Americans

The Iowa African-American Journal, Winter 2002/Spring 2003, Vol. 8, no. 2

Newsletter for the Iowa Commission on the Status of African-Americans

The Iowa African-American Journal, October 1999, Vol. 5, no. 4

Newsletter for the Iowa Commission on the Status of African-Americans

Iowa African-American Journal, Fall 2004, Vol. 10, no. 2

Newsletter for the Iowa Commission on the Status of African-Americans

Iowa African-American Journal, Spring 2004, Vol. 9, no. 1

Newsletter for the Iowa Commission on the Status of African-Americans

Iowa African-American Journal, Winter 2004, Vol. 10, no. 2

Newsletter for the Iowa Commission on the Status of African-Americans. Vol. 10, no. 2 also used for Fall 2004.

Iowa African-American Journal, February 2006, Black History Month Special Edition

Newsletter for the Iowa Commission on the Status of African-Americans. Black History Month Special Edition.